Health & Medicine in the 15th century

29 sourced entries, 1400 CE to 1499 CE, oldest first. Also see Health & Medicine across every century or everything else in the 15th century.

• 1400The Mississippian culture starts to decline.source
• 1400Europe is reported to have around 52 million inhabitants.source
• 1400The House of Medici becomes powerful in Florence.source
• 1403The world's first quarantine station, the Lazzaretto Vecchio, is built in Venice, to protect against the Black Death.source
• 1409February 24 – Traveling in Valencia in Aragon, Father Joan Gilabert Jofré, known as "Padre Jofré", witnesses a mentally ill man being beaten by two young attackers. After rescuing the victim, Jofré resolves to create the Hospital dels Ignoscents, the world's first psychiatric hospital.source
• 1410February 26 – A papal bull is issued from Avignon by the Antipope Benedict XIII for Joan Gilabert Jofré to create the Hospital dels Ignoscents, the world's first hospital for the treatment of mental illness.source
• 1412The Black Death sweeps England for a final time, in a 60-year period.source
• 1412John II of Castile declares the Valladolid laws, that restrict the social rights of Jews. Among many other restrictions, the laws force Jews to wear distinctive clothes, and deny them administrative positions.source
• 1414August 29 – The brotherhood of the "Sancta dels Folls Dona Nostra i Desamparats Innocents" (Our Lady of the Insane and the Forsaken Innocents) is founded in Valencia to help the mentally ill, but soon extends its mission to take care of homeless and abandoned children.source
• 1414Alien priory cells are suppressed in England.source
• 1422October 21 – King Charles VI of France passes away at the age of 53 after years of mental illness, and rival groups fight over who his successor will be. In Paris, Henry VI of England, the 10-month old son of the late French regent, England's King Henry V, and grandson of King Charles VI, is proclaimed King Henri II of France. In Bourges, the Dauphin Charles, eldest son of King Charles VI, is proclaimed as King Charles VII.source
• 1422On the Italian Peninsula, Venice has a population of 84,000, of which 200 men rule the city, while Florence has a population of 40,000, of which 600 men rule the city.source
• 1435China returns to a policy of isolation.source
• 1437April 2 – A bubonic plague epidemic strikes the independent city of Ragusa (modern-day Dubrovnik in Croatia), capital of the Republic of Ragusa, and a group of 10 patricians reject the chance to flee, staying to govern the city. Within 15 days, nine of the ten are dead, and only Marin Simunov Rastic survives. The progress of the plague, which lasts for more than two months, is chronicled by an Italian-born resident, Opis Diversis.source
• 1437June 24 – On the feast day of St. John the Baptist, the plague in Ragusa is declared at an end.source
• 1438October 17 – Erik of Pomerania, King of Sweden, Denmark and Norway, loses direct control of Sweden, as Karl Knutsson Bonde is elected Regent of Sweden.source
• 1450October 5 – Jews are expelled from Lower Bavaria, by order of Duke Ludwig IX.source
• 1454December – King Henry VI of England having regained his sanity dismisses the Duke of York as Protector.source
• 1456February 25 – As King Henry VI of England recovers from a three-month bout with mental illness, Richard Plantagenet, Duke of York steps down as Protector of the Realm and the King resumes his duties. The Duke of York had served as regent since November 19, and had previously been Lord Protector for 10 months during 1454 and 1455.source
• 1464September 26 – A group of merchants from the Republic of Venice arrive in London, apparently infected with the bubonic plague and the disease begins to spread rapidly.source
• 1464October 5 – An intelligence report sent by a Venetian agent in Bruges to the Seignory of Venice reports that the death rate in London from the plague has reached 200 people per day, only nine days after the first case was discovered.source
• 1466October 9 – King James III of Scotland gives royal assent Among the many acts passed into law by the Parliament, including the Hospitals Act ("for the reformacioune of the hospitalis") and the Benefices Act against Englishmen being allowed to receive a benefice (payment of a reward for services rendered) from the Crown or from the Church ("na Inglis man have benefice with Scotlande")source
• 1471World population reaches 500 million.source
• 1479The plague breaks out in Florence.source
• 1485August 5– The first outbreak of sweating sickness in England begins.source
• 1491The population of China reaches 56.238 million.source
• 1495August 7 – The Diet of Worms is adjourned in the Holy Roman Empire after more than four months, with an agreement among the constituent states to enact the Ewiger Landfriede (Eternal Peace), outlawing feuds between the states and the Holy Roman Empire's family groups, and to resolve controversies in a new Imperial Court (Reichskammergericht) and the Aulic Council.source
• 1497October – Persecution of Jews and Muslims by Manuel I of Portugal: Date under the decree of December 5, 1496, by which Portuguese Jews who have not converted are to be expelled from the country.source
• 1499June 15 – The Great Epidemic of plague reaches London, forcing King Henry and Queen Elizabeth to flee to the capital to Langley on June 25 and then to Abingdon.source