Conflict & Security in the 16th century
1,025 sourced entries, 1500 CE to 1599 CE, oldest first. Also see Conflict & Security across every century or everything else in the 16th century.
- 1500January 5 – Duke Ludovico Sforza recaptures Milan, but is soon driven out again by the French.source
- 1500February 5 – Ludovico Sforza's Swiss mercenary army retakes the city of Milan from the French during the Second Italian War.source
- 1500February 17 – Battle of Hemmingstedt: The Danish army fails to conquer the peasants' republic of Dithmarschen.source
- 1500June 29 – A combined force of troops from the Kingdom of France and from the Republic of Florence lay siege to the city of Pisa.source
- 1500July 14 – The Muscovites defeat the Lithuanians and the Poles in the Battle of Vedrosha.source
- 1500July 24 – Ottoman–Venetian War: The Turkish fleet of Kemal Reis defeats the Venetians in the Second Battle of Lepanto.source
- 1500August 9 – The Ottoman Empire defeats the Venetians and capture Modon and Coron, the "two eyes of the Republic".source
- 1500October 22 – Nasir-ud-Din Shah overthrows the government of his father, Ghiyath Shah, ruler of the Malwa Sultanate (located in much of what is now the Indian state of Madhya Pradesh) for the last 31 years. Upon becoming the new Sultan, Nasir has his brother Ala-ud-Din executed, along with Ala-ud-din's children. Ghiyasuddin is poisoned the following February.source
- 1500December 24 – The Siege of the Castle of St. George ends, and the island of Cephalonia is captured by a joint Venetian–Spanish fleet.source
- 1501April 11 – The Rebellion in the Alpujarras ends in southern Spain with a treaty of surrender of the last Muslim insurgents in the Alpujarra Mountains in Andalusia on the Mediterranean Sea. The Muslims are given the choice of expulsion or conversion to Christianity.source
- 1501June 24 – Cesare Borgia's French troops storm and overtake the fortress at Capua in the Kingdom of Naples, overcoming the defense of Fabrizio Colonna in the occupation of the Spanish Kingdom of Aragon in southern Italy.source
- 1501July 25 – The Kingdom of Naples, led by King Federico I, surrenders to Cesare Borgia's French and Aragonese troops.source
- 1501August 1 – Hans, King of Denmark, Norway and Sweden is deposed from the Swedish throne after fleeing the country following the victory of Swedish rebels at Örebro during the War of Deposition against King Hans. His wife, Christina of Saxony, is left behind at Stockholm as his regent of Sweden, to command a royal garrison at Tre Kronor ("Three Crowns"), the royal castle. Returning to Denmark, King Hans then organizes Danish troops to attempt to retake Sweden in the Dano-Swedish War (1501–1512).source
- 1501August 27 – Battle of the Siritsa River: The Livonian Order, supporting the Grand Duchy of Lithuania in the Second Muscovite–Lithuanian War, and commanded by Wolter von Plettenberg, defeats an army of the Grand Duchy of Moscow and Pskov Republic.source
- 1501November 4 – Second Muscovite–Lithuanian War: At the Battle of Mstislavl, Grand Prince Ivan's Southern Muscovite army defeats the forces of the Grand Duchy of Lithuania.source
- 1501November 24 – A large army of the Grand Duchy of Moscow overruns Livonia during the Second Muscovite–Lithuanian War.source
- 1501December 31 – First Battle of Cannanore: João da Nova fleet engaged the fleet of the Zamorin in a battle outside of the Cannanore harbor, the first Portuguese naval battle in the Indian Ocean.source
- 1502November 7 – Ismail I founds the Safavid dynasty and proclaims himself the Shah of Iran after defeating tribes of the Aq Qoyunlu confederation.source
- 1502Meñli I Giray defeats the Golden Horde and sacks their capital, Sarai.source
- 1503February 13 – Challenge of Barletta: Thirteen Italian knights defeat thirteen French knights, near Barletta.source
- 1503February 23 – Third Italian War: Battle of Ruvo – The Spanish defeat the French in Italy.source
- 1503April 2 – The Kingdom of Cochin (ruled by a Portuguese-installed raja, Unni Ramman Koyil II in modern-day India's Kerala state) is invaded by 50,000 Nair troops of the Zamorin of Calicut.source
- 1503April 21 – Third Italian War: Battle of Seminara – Spanish forces under Fernando de Andrade de las Mariñas defeat the French under Bernard Stewart, 4th Lord of Aubigny, who is captured, in Calabria.source
- 1503April 28 – Third Italian War: Battle of Cerignola – Spanish forces under Gonzalo Fernández de Córdoba defeat the French under Louis d'Armagnac, Duke of Nemours, who is killed, in Apulia. This is considered to be the first battle in history won by gunpowder small arms.source
- 1503May 13 – Naples is captured by the Spanish.source
- 1503June 21 – Murad, the last Sultan of Aq Qoyunlu in modern-day eastern Turkey fights the Safavid King of Persia, Ismail I in a battle near the city of Hamadan, and suffers 10,000 casualties, including his commander Güzel Ahmad.source
- 1503November 11 – Bernard Stewart, 4th Lord of Aubigny, commander of the defeated French forces and a prisoner of war since his April 21 defeat at the Battle of Seminara, is released from Castel Nuovo in Naples after a truce between France and Spain.source
- 1503December 29 – Third Italian War: The Battle of Garigliano takes place near Gaeta in Italy. Spanish forces under Gonzalo Fernández de Córdoba defeat a French–Italian mercenary army under Marchese Ludovico II of Saluzzo; the French forces, who suffer 4,000 casualties, withdraw to Gaeta.source
- 1504January 1 – French troops of King Louis XII surrender Gaeta to the Spanish, under Gonzalo Fernández de Córdoba.source
- 1504March 16 – In what is now India's Kerala state, a second invasion of the Portuguese-supported Kingdom of Cochin by the Zamorin of Calicut takes place, beginning a war that lasts until July 3.source
- 1504March 30 – The Eisho era begins in Japan during the reign of Emperor Go-Kashiwabara as the Bunki era ends.source
- 1504April 23 – Maximilian I, Holy Roman Emperor grants the Landshut inheritance to Albert IV during the War of the Succession of Landshut. Maximilian would pronounce an imperial ban on Ruprecht on May 4, whom Albert contested for the territory.source
- 1504July 3 – The siege of Cochin in India by the invading forces of Calicut ends as the Portuguese and Cochin defenders defeat the invaders. Calicut loses 5,000 dead in battle and another 13,000 to disease, while Cochin and Portugal sustain minimal losses.source
- 1504August 19 – The Battle of Knockdoe is fought in Ireland's County Galway as 6,000 troops led by the English Lord Deputy of Ireland, Gerald FitzGerald, 8th Earl of Kildare assist Maelsechlainn mac Tadhg Ó Cellaigh, King of Uí Mháine, against 4,000 troops of Irish chieftain Ulick Fionn Burke, Lord of the Clanricarde lands. Burke had previously attacked and destroyed Ó Cellaigh's castles at Monivea, Castleblakeney and Garbally and sought Kildare's help. Kildare's forces win the battle.source
- 1504October – Babur besieges and captures Kabul.source
- 1504December 24 – Nils Ravaldsson, the leader of the rebellion after Knut Alvsson's death, is attacked and his resistance crushed at Olsborg Castle in Båhuslen.source
- 1504In Florence, Leonardo da Vinci and Niccolò Machiavelli become involved in a scheme to divert the Arno River, cutting the water supply to Pisa to force its surrender: Colombino, the project foreman, fails to follow da Vinci's design, and the project is a major failure.source
- 1505July 2 – The Kalmar Bloodbath, a mass execution of participants in the Swedish Uprising against King Hans of Denmark (who also rules Norway and Sweden) takes place in the Swedish city of Kalmar after a judgment of treason is pronounced against the mayor, city officials and other leaders.source
- 1505August 16 – Almeida's fleet destroys the East African city of Mombassa.source
- 1505September 13 – In what is now Algeria, the Spanish Army under the command of Ramón de Cardona, captures the city of Mers-el-Kébir, a port of the Zayyanid Kingdom of Tlemcen, ruled by the Sultan Abu Abdallah V.source
- 1505November 6 (October 27 O.S.) – Vasili III succeeds Ivan III, as Grand Prince of Muscovy, comprising much of modern-day Russia.source
- 1505Battle of Achnashellach in Scotland: The Clan Cameron emerges victorious over Clan Munro and Clan MacKay.source
- 1506March 16 – Battle of Cannanore: Portugal's fleet (commanded by Lourenço de Almeida) defeats the fleet of the Zamorin of Calicut, with hundreds of vessels involved; 3,000 Muslim troops are killed.source
- 1506April 19 – The Lisbon Massacre begins in Portugal with three days of violence, in which thousands of Jews are tortured and killed by Catholics.source
- 1506May 28 – Emperor Moctezuma II of Mexico's Aztec Empire subdues a rebellion in Zozollan, east of Achiutia, then kills the prisoners of war as a sacrifice to the gods.source
- 1506August 6 – Battle of Kletsk: The Grand Duchy of Lithuania defeats the Tatars of the Crimean Khanate.source
- 1506September 2 – In Korea, Emperor Yonsangun, known for being a tyrant, is deposed in the Jungjong coup by his younger brother, who becomes King Jungjong.source
- 1506October 6 – In Córdoba, in the Spanish kingdom of Andalusia, members of the nobility and the general public revolt against the Spanish inquisitor Diego Rodriguez de Lucero and General Inquisitor Diego de Deza. The mob liberates the people incarcerated at the Córdoba prison.source
- 1507March 1 – Eleven months after the Lisbon Massacre, King Manuel I of Portugal issues an edict permitting the cristãos-novos ("New Christians", Portuguese Jews who had been forced to convert to Christianity) to freely emigrate from the kingdom.source
- 1507March 11 – Italian mercenary leader and former prince Cesare Borgia, later cited by Niccolò Machiavelli in The Prince as an example of "conquest by fortune", completes his conquest of the Spanish city of Viana by driving out the defenders of the castle of the Count of Lerín, but makes the mistake of pursuing the fleeing enemy by himself. He is killed the next day by his captors.source
- 1507March 28 – The revolutionary council of the Republic of Genoa declares a war against French invaders.source
- 1507April 27 – In India, in what is now the state of Kerala, troops from the Kingdom of Cannanore begin a four-month siege of the Portuguese garrison at the Fort of Saint Angelo. Despite being outnumbered, the 150 defenders of the fort hold out for four months against 60,000 attackers until rescue arrives four months later.source
- 1507April 29 – French troops retake the city of Genoa after a seven-day siege, defeating rebels who had taken control in July 1506.source
- 1507May 14 – In Italy, King Louis XII of France departs from Genoa and makes a triumphant entry into Milan on May 24.source
- 1507August 27 – A fleet of 11 ships from the Portuguese Navy's 8th Armada arrives in India and rescues the Portuguese defenders of the fort of Saint Angelo from the attack by the Kingdom of Cannanore.source
- 1507November 24 – Portuguese Admiral Tristao da Cunha, with 12 ships, attacks a fleet of 13 Muslim merchant ships leaving the Indian port of Ponnani, and is confronted by the forces of Kutti Ali. The Portuguese win the battle.source
- 1507The Electron Lahar occurs on Mount Rainier in Washington state.source
- 1507The Timurid Dynasty ends, when Uzbeks under Muhammad Shaybani capture the capital, Herat, and Emir Badi' al-Zaman Mirza flees.source
- 1508January 24 – Maximilian, King of the Romans, requests permission to march to Rome through Venetian territory, but is denied and begins his Italienzug.source
- 1508February 2 – During the Glinski rebellion, Lithuanian noble Mykolas Glinskis attacks Grodno (now in Belarus) and decapitates Jan Zabrzeziński, the top ally of Grand Duke Alexander.source
- 1508February 20 – Maximilian I, Holy Roman Emperor, attacks the Republic of Venice and sack Ampezzo the next day.source
- 1508March 2 – The Republic of Venice defeats Maximilian I in the Battle of Cadore.source
- 1508June 6 – Holy Roman Emperor Maximilian I signs a humiliating armistice with the Republic of Venice, which for the moment stops any of his further plans for Italy.source
- 1508July 31 – The Emperor of Ethiopia, Na'od, dies in battle. His son Lebna Dengel takes on the regnal name of Dawit II, and becomes the new emperor starting on August 11.source
- 1508December 29 – Battle of Dabul: Portuguese forces, under the command of Francisco de Almeida, attack Khambhat.source
- 1509January 30 – French ambassador Janus Lascaris leaves Venice, after being recalled by king Louis XII in the eve of the War of the League of Cambrai.source
- 1509February 3 – Battle of Diu: The Portuguese defeat a coalition of Indians, Muslims and Italians.source
- 1509April 17 – In Venice, the envoy of the French king Louis XII delivers the declaration of war to the Venetian doge Leonardo Loredan, thus marking the official beginning of the War of the League of Cambrai.source
- 1509May 9 – The French army under the command of Louis XII crosses the Adda River at Cassano d'Adda.source
- 1509May 14 – Battle of Agnadello: French forces defeat the Venetians. The League of Cambrai occupies Venice's mainland territories.source
- 1509May 17 – Venice made an effort to appease the emperor Maximilian I by offering various political and territorial concessions, but the effort failed.source
- 1509July 17 – Venetian forces retake the city of Padua from French forces.source
- 1509August 10 – Maximillian I of the Holy Roman Empire along with French allies begins a siege of Padua that would last for months to retake the city.source
- 1509October 1 – The siege of Padua ends with Venetian victory, causing the retreat of HRE and French forces back to Tyrol and Milan.source
- 1509November 4 – Afonso de Albuquerque becomes the Viceroy of Portuguese India, replacing Francisco de Almeida, who departs five days later from Diu. Almeida never makes it home, getting killed along with his 64 men in a battle on March 1 with the local Khoekhoe people at South Africa's Cape of Good Hope.source
- 1509December 1 – Prince Le Oanh is installed as the new Emperor of Vietnam by a coup d'etat against his cousin, Emperor Le Uy Muc, and is enthroned at the age of 14 as Emperor Le Tuong Duc. Uy Muc is granted his request to be allowed to commit suicide rather than to be executed.source
- 1510February 27– Portuguese conquest of Goa: Afonso de Albuquerque of Portugal begins a nine month battle to conquer Goa off the coast of India.source
- 1510March 1 – Battle of Salt River: Indigenous ǃUriǁʼaekua decisively defeat sailors of the Portuguese Empire in South Africa.source
- 1510March 12 – Mihnea cel Rău, the ruling Prince of Wallachia (now in Romania), is assassinated in Sibiu while attending Mass at the Roman Catholic church there.source
- 1510April 4 – The "Disturbance of the Three Ports", an uprising by Japanese merchants against the Korean government, begins in what is now South Korea in the cities of Dongnae, Changwon and Ulsan.source
- 1510April 19 – The simultaneous Japanese uprising in Korea is suppressed by the Korean Emperor Jungjong, and all trade between Korea and Japan is halted for the next two years.source
- 1510May 12 – The Prince of Anhua rebellion begins when Zhu Zhifan, Prince of Anhua, kills all the officials invited to a banquet, and declares his intent on ousting the powerful Ming dynasty eunuch Liu Jin, during the reign of the Zhengde Emperor in China.source
- 1510May 30 – Rebel leader Zhu Zhifan is defeated and captured by commander Qiu Yue, ending the Prince of Anhua rebellion.source
- 1510June 5 – The Sultan Abu Abdallah V of Tlemcen (now part of Algeria) agrees to pay a demand for tribute to the Ferdinand II, King of Aragon (now part of Spain), prompting Ferdinand to plot an invasion of the neighboring kingdom Ifriqiya and its capital, Tripoli.source
- 1510July 25 – Spanish troops capture Tripoli at the direction of King Ferdinand II of Aragon and under the command of Pedro Navarro.source
- 1510December 2 – Battle of Merv: Shah Ismail I's defeats the Uzbek forces of Shaybani Khan, in Khorasan. Shaybani flees the battle only to be captured and killed by Ismail I troops, his head is turned into a skull cup used as a drinking goblet.source
- 1510The Grand Prince of Moscow Vasili III conquers Pskov.source
- 1511January 19 – The Siege of Mirandola by the Papal States, with help from the Duchy of Urbino and Spanish and Venetian troops, ends with the capture of Mirandola after 18 days of fighting. The Pope personally leads the troops and, after the outnumbered defenders surrender, works at preventing his troops from pillaging the city or harming the residents.source
- 1511February 27 – In Italy, on "Fat Thursday", a Christian celebration marking the last days of feasting before the period of fasting during the Roman Catholic Lent, discontented citizens of Friuli stage a revolt against their Venetian occupiers and attack the city of Udine and invade the palaces of several members of nobility, murdering the wealthy families and plundering the palace contents. Special troops arrive from Gradisca d'Isonzo on March 1 and suppress the rebellion.source
- 1511March 11 – On the island of Puerto Rico, Spanish conquistador Juan Ponce de León leads an incursion at Yahuecas against the local Taino warriors, commanded by Chief Urayoán.source
- 1511April 9 – The Şahkulu Rebellion breaks out in Anatolia.source
- 1511May 23 – French troops capture the Italian city of Bologna after a two-day battle.source
- 1511July 2 – The Şahkulu rebellion, which had started in Anatolia by Sakhulu Baba, against the Ottoman Empire on April 9, is suppressed in southeastern Turkey by the Ottoman Grand Vizier, Hadım Ali Pasha and Prince Şehzade Ahmed, son of the Sultan Bayezid II. Sakhulu is subsequently beheaded.source
- 1511July 25 – Afonso de Albuquerque of Portugal, Governor of Portuguese India, begins an assault on the strategic city of Malacca (now part of Malaysia) and captures it by August 15.source
- 1511September 27. Imperial troops capture Gradisca d'Isonzo from the Venetians, also operating in other parts of Friuli and northern Italy, together with their French allies.source
- 1511The indigenous Taíno people revolt against the Spanish in southwestern Puerto Rico near Guánica.source
- 1512January 23 – Neagoe Basarab becomes the new Prince of Wallachia at the capital, Târgoviște, after Prince Prince Vlad V is captured at battle in Bucharest and then decapitated.source
- 1512February 18 – War of the League of Cambrai: The French carry out the Sack of Brescia.source
- 1512April 11 – War of the League of Cambrai – Battle of Ravenna: French troops under Gaston of Foix, Duke of Nemours, assisted by the Duchy of Ferrara, defeat the Spanish and Papal States troops led by Ramón de Cardona. Gaston is killed in the pursuit as the Spanish retreat, and at least 3,000 of his troops are killed. More than 9,000 Spanish and Papal troops are killed, and 17,000 civilians in and around the city of Ravenna are massacred.source
- 1512May 26 – Selim I succeeds Bayezid II, as Sultan of the Ottoman Empire.source
- 1512August 10 – War of the League of Cambrai – Battle of Saint-Mathieu: The English navy defeats the French-Breton fleet. Both navies use ships firing cannons through ports, and each loses its principal ship — Regent and Marie-la-Cordelière — through a large explosion aboard the latter.source
- 1512September 1 – After being dispatched by Pope Julius II with command of a Spanish Army, General Giovanni di Lorenzo de' Medici recaptures the city of Florence (Firenze), capital of the Florentine Republic in Italy and ousts Piero Soderini as the ruling Gonfaloniere. The success at Florence spares the city of Rome from a French invasion. Within a year, Medici becomes leader of the Roman Catholic Church and the Papal States as Pope Leo X.source
- 1512September 10 – Portuguese Admiral Afonso de Albuquerque departs from the Indian city of Cochin with 14 ships and 1,700 troops to retake the fortress of Goa, capital of Portuguese India, from Bijapur's General Rasul Khan. A day before a planned Portuguese attack on Bihar's army, Rasul Khan and his occupying forces depart from Goa.source
- 1513March 15 – In the Taino Rebellion on the island of Puerto Rico, Spanish conquistador Diego Guilarte de Salazar attacks the Taino towns of Yauco and Coxiguex.source
- 1513March 26 – On Easter Sunday, Afonso de Albuquerque, Governor of Portuguese India, makes an unsuccessful attempt to capture the port city of Aden, on the Arabian Peninsula, from the Mamluk Sultanate, using 20 ships and 2,500 soldiers. The 1,700 Portuguese, along with 800 mercenaries from Malabar, lose at least 100 killed during the attack and retreat.source
- 1513May 25 – Giano II di Campofregoso resigns as Doge of the Republic of Genoa as plots by two opposing families restore the influence of France. Campogregoso leaves the city on a ship to serve the Republic of Venice in its war against the Duchy of Milan.source
- 1513June 6 – Italian Wars: Battle of Novara – Swiss mercenaries supporting the Milanese defeat the French under Louis II de la Trémoille, forcing the French to abandon the Duchy of Milan and Italy.source
- 1513August 5 – A force of 7,000 Scottish border troops, commanded by Lord Home, invades England and begins the destruction and pillaging of villages in Northumberland.source
- 1513August 16 – Battle of Dubica (part of the Hundred Years' Croatian–Ottoman War): Croatian troops under Petar Berislavić, Ban (Viceroy) of Croatia, defeat an Ottoman army under Sanjak-bey Junuz-aga.source
- 1513August 16 – Battle of the Spurs (or Battle of Guinegate, part of the War of the League of Cambrai): English and allied troops under Henry VIII defeat French cavalry under Marshal La Palice.source
- 1513August 23 – Thérouanne in the north of France is given to Henry VIII of England after a treaty is concluded in the aftermath of the Battle of the Spurs.source
- 1513September 9 – Battle of Flodden: King James IV of Scotland is defeated and killed by an English army under Thomas Howard, Earl of Surrey. James's infant son, the Duke of Rothesay, becomes James V, King of Scots. At least 5,000 Scots and 1,500 English troops are killed.source
- 1513October 7 – Battle of La Motta (War of the League of Cambrai): Spanish and imperial troops under Ramón de Cardona decisively defeat those of the Republic of Venice under Bartolomeo d'Alviano in Schio.source
- 1513Leo Africanus visits Timbuktu, second city of the Songhai Empire.source
- 1514February 12 – War of the League of Cambrai: In what is now the Italian region of Friuli-Venezia Giulia, Giacomo Badoer, administrator of the Republic of Venice, orders a retreat from the approaching forces of the Holy Roman Empire, abandoning Udine, Cividale and Cormons and falling back on Sacile.source
- 1514May 2 – The Poor Conrad peasant revolt against Ulrich, Duke of Württemberg begins in Beutelsbach.source
- 1514July 14 – The Hungarian rebel leader György Dózsa is defeated in battle at Temesvár in Transylvania in Hungarysource
- 1514August 1 – Vasili III of Russia captured Smolensk from Grand Duchy of Lithuania.source
- 1514August 23 – Battle of Chaldiran: Selim I crushes the Persian army of Shah Ismail I.source
- 1514September 7 – The Ottoman Army, commanded by the Sultan Selim I, arrives at Tabriz, capital of Safavid Iran and accepts the surrender of Shah Ismail.source
- 1514September 8 – Forces of the Grand Duchy of Lithuania and the Kingdom of Poland, backed by Belarusians, with 30,000 troops, defeat the larger Russian army of the Grand Duchy of Moscow (80,000 soldiers) in the Battle of Orsha.source
- 1514December 29 – Giovanni Carlo Tramontano, Count of Matera, is assassinated in Matera, the day after demanding that the aristocracy and people of his realm pay 24,000 ducates in taxes to clear up his personal debts.source
- 1515January - In Vietnam, an uprising led by Phùng Chương broke out in Tam Đảo and was quickly quelled by general Trịnh Duy Sản under emperor Lê Tương Dực of the Lê dynasty.source
- 1515April 15 – The Emirate of Oman, ruled by Muhammad bin Ismail, becomes a protectorate of Portugal.source
- 1515April 23 – In Portuguese-occupied Morocco, the Governor of Safi, Nuno Fernandes de Ataíde, conducts an unsuccessful attack on Marrakesh, and is forced to retreat by defenders led by the Emir Nasr ibn Chentaf al-Hintati.source
- 1515June 13 – Battle of Turnadag: The army of Ottoman sultan Selim I defeats the beylik of Dulkadir under Bozkurt of Dulkadir.source
- 1515September 14– The Battle of Marignano concludes after two days as the army of Francis I of France defeats the Swiss mercenaries, thanks to the timely arrival of a Venetian army. The French Army enters the Duchy of Milan on September 17 and reclaims it for King Francis.source
- 1515October 4 – Maximilian Sforza, Duke of Milan, surrenders to the French forces and is imprisoned until the arrival of King Francis.source
- 1515October 11 – King Francis enters the city of Milan with Charles III, Duke of Savoy and William IX, Marquis of Montferrat. Francis becomes Duke of Milan and sends Duke Maximilian into exile in France, providing hm with an annual annuity of 35,000 écus.source
- 1516July 28 – Selim I of the Ottoman Empire captures the city of Malatya (located in what is now southeastern Turkey) as the first conquest in his war against the Mamluk Sultanate of Egypt and then proceeds to invade Syria.source
- 1516August 24 – Ottoman–Mamluk War (1516–17): The Ottoman Sultan Selim I defeats the Mamluk forces commanded by the sultan Al-Ashraf Qansuh al-Ghuri in the Battle of Marj Dabiq, bringing all of the Middle East. The Mamluk Sultan, Al-Ashraf Qansuh al-Ghuri, is killed while leading his troops in the battle, and Prime Minister Al-Ashraf Tuman Bay, who was left in charge in Cairo by the Sultan Qansuh, becomes the Sultan of Egypt, the last remaining part of the Mamluk Sultanate.source
- 1516October 28 – Ottoman–Mamluk War (1516–17): Ottoman forces under the Grand Vizier Sinan Pasha defeat the Mamluks in the Battle of Yaunis Khan near Gaza.source
- 1517January 22 – Battle of Ridaniya: The Ottoman army of sultan Selim I defeats the Mamluk army in Egypt, commanded by king Tuman Bay II.source
- 1517February 3 – The Ottoman Sultan Selim I makes a triumphant entry into Cairo after his Janissaries have cleared the area of the Mamluk defenders.source
- 1517March 26 – More than two months after fleeing Cairo and attempting a counterattack against the Ottomans, Tuman Bay II is captured alive with many of his Mamluk officers. Selim initially plans to exile Tuman Bey and other former Mamluk nobles to Constantinople, but changes his mind.source
- 1517April 12 – Lopo Soares de Albergaria of Portugal begins the siege of Jeddah (now part of Saudi Arabia), attempting to invade, but is unable to land because of artillery fire from the Ottoman and Mamluk defenders. Bad weather prevents the Portuguese fleet of 15 ships from navigating for the next two weeks.source
- 1517April 15 – The Ottoman–Mamluk War officially ends as the Ottoman Empire annexes the Mamluk Sultanate territories in the Middle East (the Levant), the Arabian Peninsula (Hejaz) and Egypt as provinces.source
- 1517April 25 – After 13 days of continuous storms and being unable to do more than destroy one Jeddah ship (while losing two of its own), the Portuguese fleet abandon its planned invasion of the Arabian peninsula.source
- 1517April 30 – Anticipating a riot in London, the Lord Mayor announces at 8:30 in the evening that a curfew will begin within 30 minutes, at 9:00. An attempt by a local alderman, John Mundy, to enforce the curfew triggers the attack by a mob hours later.source
- 1517May 1 – Evil May Day: Xenophobic riots break out in London as English citizens attack foreigners, including Flemish shoemakers and French royal courtiers. The Duke of Norfolk leads a private army of 1,300 men to put down the rioting.source
- 1517June 24 – Pier Gerlofs Donia, leader of a rebellion of the Frisians minority of the Netherlands, leads 4,000 of his Arumer Zwarte Hoop soldiers on an attack against the Dutch inhabitants of Medemblik, then moves on to a massacre of the residents of the village of Asperen.source
- 1517Grand Prince Vasili III of Muscovy conquers Ryazan.source
- 1518July 27 – Battle of Brännkyrka: The Kalmar Union, led by King Christian II of Denmark, is defeated by the Swedish regent Sten Sture the Younger.source
- 1518The Rajput Mewar Kingdom under Rana Sanga achieves a major victory over Sultan Ibrahim Lodi of Delhi.source
- 1519July 10 – The Prince of Ning rebellion begins, after Zhu Chenhao declares the Ming dynasty's Zhengde Emperor a usurper, and leads his army north in an attempt to capture Nanjing.source
- 1519August 20 – Ming Dynasty Chinese philosopher and general Wang Yangming, governor of Jiangxi, defeats Zhu Chenhao, ending the Prince of Ning rebellion. Wang has expressed the intention of using fo–lang–ji cannons in suppressing the rebellion, probably the earliest reference in China to the breech-loading Frankish culverin.source
- 1519October 12 – Hernán Cortés and his men, accompanied by 3,000 Tlaxcalans, enter Cholula.source
- 1519November 8 – Hernán Cortés enters Tenochtitlan, capital of the Aztec Empire, and appears at the court of Aztec ruler Moctezuma II.source
- 1519December 11 – At Toruń, the members of the Sejm of the Kingdom of Poland vote to approve a war against the Teutonic Knights and to assess new taxes to recruit mercenary troops.source
- 1519The Mexican Indian Wars begin.source
- 1519The first civil revolt in Anatolia takes place, led by Alevi preacher Celâl.source
- 1520January 19 – King Christian II of Denmark and Norway defeats the Swedes, at Lake Åsunden in Sweden. The Swedish regent Sten Sture the Younger is mortally wounded in the Battle of Bogesund. He is rushed towards Stockholm, in order to lead the fight against the Danes from there.source
- 1520April 2 – Juan de Cartagena, formerly captain of the largest ship on the Magellan expedition, San Antonio, escapes captivity from the Victoria and begins a mutiny against Ferdinand Magellan. He is joined by Gaspar de Quesada, captain of the Concepción, and Luis de Mendoza, captain of the Victoria. On the first day of the rebellion, under the pretense of delivering Magellan's letter of surrender to the Victoria, several crew from the Magellan's flagship Trinidad stab Mendoza to death, and the rest of the Victoria crew seizes the mutineers.source
- 1520April 3 – The crew of the San Antonio surrenders to Magellan after being unable to stop drifting in strong winds and being fired at by a cannon, and Gaspar de Quesada surrenders the Concepcion. Four days later, Quesada is beheaded along with other mutineers, while Cartagena is left on an island by Magellan in August.source
- 1520April 16 – Revolt of the Comuneros: Citizens of Toledo, Castile opposed to the rule of the Flemish-born Charles V, Holy Roman Emperor, rise up when the royal government attempts to unseat radical city councilors.source
- 1520May 22 – The Massacre in the Great Temple of Tenochtitlan takes place in Mexico after the Aztec Emperor Moctezuma II is allowed by the Deputy Governor of New Spain, Pedro de Alvarado, to host Aztec nobles at the Great Temple at Tenochtitlan to celebrate the Feat of Toxcatl in honor of the god Tezcatlipoca. Alvarado uses the opportunity to kill more than 600 Aztec warriors and commanders, but spares Moctezuma.source
- 1520June 10 – Revolt of the Comuneros: Segovia is blockaded.source
- 1520June 29 – Moctezuma II, Aztec ruler of Tenochtitlan, is assassinated by other Aztec leaders as he attempts to address his people. His brother Cuitláhuac rises to the throne.source
- 1520July 7 – Otumba near Lake Texcaco: The Spaniards defeat the Aztecs.source
- 1520August 11 – Ferdinand Magellan maroons the two surviving people who had attempted a mutiny against him, Captain Juan de Cartagena and Father Pedro Sánchez de la Reina, placing them on an island off of the coast of Argentina and providing them with a small supply of ship's biscuits and drinking water. Cartagena and Sanchez are never heard from again.source
- 1520August 24 – The French warrior René of Savoy departs from Marseille on his flagship, Sainte Marie de Bonaventure on a four-month mission to protect the Knights Hospitaller against an attack by the Ottoman Turks.source
- 1520September 7 – Christian II of Denmark makes his triumphant entry into Stockholm, which had surrendered to him a few days earlier. Sten Sture's widow Christina Gyllenstierna, who has led the fight after Sten's death, and all other persons in the resistance against the Danes, are granted amnesty and are pardoned for their involvement in the resistance.source
- 1520November 7 – At the end of the third day of Christian's coronation feast, several leading figures of the Swedish resistance against the Danish invasion are imprisoned, and tried for high treason.source
- 1520November 9– Stockholm Bloodbath: The execution of 82 Swedish noblemen and clergymen, having been sentenced to death for their involvement in the Swedish resistance against the Danish invasion, is completed after two days of beheading.source
- 1521January 27 – Suleiman the Magnificent suppresses a revolt by the ruler of Damascus, Janbirdi al-Ghazali.source
- 1521March 16 – Ferdinand Magellan reaches the Philippines, in eastern Samar.source
- 1521April 23 – Revolt of the Comuneros – Battle of Villalar: Castilian royalists defeat the rebels. Juan López de Padilla, Francisco Maldonado, and Juan Bravo are executed the following day as the leaders of the rebels.source
- 1521April 27 – Battle of Mactan: Ferdinand Magellan is killed in the Philippines when he confronts Lapulapu, the chief of the island.source
- 1521April or May – Battle of Tunmen in Tuen Mun (present-day Hong Kong): The Ming Dynasty navy defeats the Portuguese navy (arguably the first Sino-European battle in world history).source
- 1521May 17 – Edward Stafford, 3rd Duke of Buckingham, is executed for treason in Tower Hill.source
- 1521May 20 – At the Battle of Pampeluna in Spain, and alliance of forces from French and the Kingdom of Navarre forces defeat those of Spain.source
- 1521June 25 – Suleiman the Magnificent begins the siege of Belgrade.source
- 1521June 29 or 30 – The oldest surviving dateable document written primarily in the Romanian language: Neacșu's letter, written by a trader from Câmpulung, to Johannes Benkner, the mayor of Brașov, warning that the Ottoman Empire is preparing its troops to cross into Wallachia and Transylvania; the script used is Romanian Cyrillic.source
- 1521June 30 – Battle of Esquiroz: French forces under André de Foix, fighting for the exiled King of Navarre Henri d'Albret, are defeated by the Spanish, and forced to abandon their attempt to recover Henri's kingdom.source
- 1521August 13 – Fall of Tenochtitlan: Cuauhtémoc surrenders to Cortés, thus incorporating the Aztec Empire into the Spanish Empire and ending the Late Postclassic period in Mesoamerica.source
- 1521August 20 – The Italian War of 1521–1526 breaks out between Charles V, Holy Roman Emperor, and Francis I of France as Henry III of Nassau-Breda leads Imperial troops on an invasion of northeastern France.source
- 1521August 29 – Belgrade is captured by the Ottoman army of Suleiman the Magnificent.source
- 1521September 12 – In the Italian War, the Holy Roman Empire abandons its siege of the French-controlled city of Parma after 17 days.source
- 1521October 25 – The Revolt of the Comuneros, an uprising by citizens of the Kingdom of Castile against the rule of Spain's King Carlos I, ends as the comuneros surrender Toledo.source
- 1521The Grand Duchy of Ryazan is annexed by the Grand Duchy of Moscow.source
- 1521The Swedish Army was founded by Gustav Vasa.source
- 1522February 5 – In Castile in Spain, the Revolt of the Comuneros is re-ignited when King Carlos V reneges on a promised amnesty to participants in a 1520 uprising, and threatens to execute revolt leader María Pacheco. Calm is restored by the intervention of Maria de Mendoza, and while many of the rebels are punished, Pacheco is able to escape to Portugal.source
- 1522February 28 – The Viscount of Lautrec, leader of the French Army, spares the Italian residents of Treviglio from his plan of vengeance for their earlier resistance to the French troops, apparently after witnessing a miracle of seeing a fresco of the Virgin Mary shed tears.source
- 1522April 27 – In the Battle of Bicocca, French and Swiss forces under Odet de Lautrec are defeated by the Spanish in their attempt to retake Milan, and are forced to withdraw into Venetian territory.source
- 1522May 28 – The Ottoman Empire's siege of Knin in the Kingdom of Croatia is successful as Mihajlo Vojković surrenders to Gazi Husrev Bey and most of the Croatian inhabitants are allowed to leave. Inhabitants of Bosnia then move in.source
- 1522May 29 – England formally declares war on France and Scotland.source
- 1522May 30 – In Italy, the siege of Genoa, defended by France against the Holy Roman Imperial armies of General Fernando d'Avalos, ends after 10 days as the Imperial troops overrun the city. Since Genoa had refused to surrender, the Imperial troops are permitted to pillage the fallen city.source
- 1522June 19 – Charles V, Holy Roman Emperor visits King Henry VIII of England, and signs the Treaty of Windsor, pledging a joint invasion of France, bringing England into the Italian War of 1521–1526.source
- 1522July 4 – Brought on ships across the English Channel, an English fleet and army under the command of Thomas Howard, Earl of Surrey, attacks Brittany and Picardy after landing at Le Dourduff-en-Mer, near Calais, and burns and loots the countryside.source
- 1522July 23 – A counter-attack by local peasants and the French Army defeats the English Army in the first Battle of Morlaix, the day after the English pillage the town of Morlaix and begin loading their treasure on to their ships. When the French Army, commanded by Guy XVI de Laval, arrives, it finds that most of the English soldiers are either sleeping or drunk after having celebrated a conquest, and about 700 English soldiers are massacred.source
- 1522July 28 – Ottoman Sultan Suleiman I begins his siege to expel the Knights of St. John in Rhodes.source
- 1522August 15 – Ottoman General Mehmed-Bey of Nikopol enters Târgoviște and takes control of the Principality of Wallachia, now part of Romania, as Radu of Afumați is forced to flee.source
- 1522December 18 – The Ottomans finally break into Rhodes, but the Knights continue fierce resistance in the streets.source
- 1522December 20 – Suleiman the Magnificent accepts the surrender of the surviving Knights in Rhodes, who are allowed to evacuate. They eventually re-settle on Malta, and become known as the Knights of Malta.source
- 1523February 15 – Construction of Fort Kastela by Portuguese invaders, on what is now the island of Ternate in Indonesia, is completed as Portugal claims the Spice Islands (now the Maluku Islands).source
- 1523February 25 – Battle of al-Shihr on the Arabian Peninsula (in what is now Yemen): Troops from Portugal fight against the Kathiri Sultanate, ruled by the Emir Mutran bin Mansur. After a battle of one day, the Portuguese sack the capital, Al-Shihr, and establish a port on the Indian Ocean.source
- 1523March 8 – In Spain's Kingdom of Valencia, a rebellion by the Brotherhoods of Mallorca is suppressed after two years, as the rebels surrender their capital, Palma de Mallorca, to Spanish and German troops.source
- 1523April 14 – Mirza Shah Hossein, Grand Vizier of Persia since 1514, is assassinated in Qazvin (now in Iran) by Shia nobles of the Qizilbash sect, and replaced by Jalal al-Din Mohammad Tabrizi.source
- 1523April 17 – In Nicaragua, Diriangén, ruler of the Chorotega speakers, stages an attack on the Spanish invaders led by González Dávila. Having been warned by one of the Nicarao natives of the intended surprise attack, Spanish defenders on horses rout the Chorotega, but several of the Spaniards are wounded. The Spanish then decide to proceed no further inland.source
- 1523May 5 – An assassination attempt is made against King Sigismund of Poland, who is shot at while walking outside his residence at Wawel Castle overlooking Kraków.source
- 1523May 27 – Swedish War of Liberation: The city of Kalmar in Sweden, occupied by troops of Denmark, falls to a Swedish Army force led by Arvid Västgöte after the city's magistrates agree to leave the northern gate of the city open. Kalmar Castle surrenders on June 4. With the fall of Kalmar, only Stockholm remains as a site of the Danish occupation.source
- 1523May 31 – Following the Battle of Sincouwaan at sea between the ships of the Chinese Empire and the Kingdom of Portugal, the Malay ambassador to China reluctantly departs from Guangzhou to present letters to the Portuguese governors of the occupied Malacca Sultanate, demanding the restoration of the deposed Sultan. Though fearing execution by the Portuguese, the messengers are allowed to leave. They return in September with a plea for help from the Malay Sultan, whose territory is under attack from the Europeans.source
- 1523May – The Ningbo incident: Two rival trade delegations from Japan feud in the Chinese city of Ningbo, resulting in the pillage and plunder of the city.source
- 1523June 10 – Frederick begins the 8-day siege of Copenhagen, the capital of Denmark. The city surrenders on 6 January 1524.source
- 1523June 12–July 19 – Franconian War: The Swabian League destroys 23 robber baron castles.source
- 1523June 17 – Swedish War of Liberation: The surrender of Stockholm by Denmark is accepted by Sweden's King Gustav Vasa. In return, the city's defenders are allowed safe passage out of Sweden. King Gustav then makes his triumphant entry to the city on June 24.source
- 1523July 7 – Wijerd Jelckama, a Frisian warlord and military commander, is executed in Leeuwarden, ending the Frisian rebellion fought by the Arumer Black Heap.source
- 1523August 22 – Lucien Grimaldi, Lord of Monaco, is assassinated by his nephew at the Prince's Palace. Bartolomeo Doria di Dolceaqua, the son of Lucien's sister Francesca, kills his uncle and then has his men drag the monarch's body down the palace stairs in front of a horrified crowd, who drive the Doria family out of the small principality. Lucien had become the ruler in 1505 after stabbing to death his brother, Jean II. Lucien's heir is his 8-month-old son, Honoré; Lucien's brother Augustine Grimaldi becomes the regent during Honoré's minority.source
- 1523December 6 – Setting off from the Mexican Aztec capital of Tenochtitlan with an army of 550 Spanish soldiers and 120 horses, Pedro de Alvarado y Contreras begins the Spanish conquest of Guatemala.source
- 1523In northern Italy, a French army under Guillaume Gouffier tries to recover Milan but fails due to an offensive by Spanish, Imperial and English troops and they retreat in mid-November.source
- 1524February 20 – Tecun Uman, the K'iche' Maya ruler of Guatemala's highlands, is killed in a battle near Quetzaltenango between the K'iche' Maya people and the invading Spanish conquistadors led by Pedro Alvarado.source
- 1524March 7 – Spanish conquistador Pedro de Alvarado destroys the Kʼicheʼ kingdom of Qʼumarkaj, taking the capital, Quiché.source
- 1524April 30 – Battle of the Sesia: Spanish forces under Charles de Lannoy defeat the French army in Italy, under William de Bonnivet. The French, now commanded by François de St. Pol, withdraw from the Italian Peninsula.source
- 1524May 26 – Atiquipaque, the most important city of the Xinca people, is conquered by the Spanish, resulting in a significant reduction in the Xinca population.source
- 1524June 8 – Battle of Acajutla: Spanish conquistador Pedro de Alvarado defeats a battalion of Pipiles, in the neighborhoods of present day Acajutla, El Salvador.source
- 1524August 20 – The French city of Marseille is besieged by Holy Roman Empire forces commanded by the Charles III, Duke of Bourbon and lasts until September 26.source
- 1524October 28 – A French army invading Italy, under King Francis, besieges Pavia, months before the Battle of Pavia.source
- 1524November 1 – John Fleming, 2nd Lord Fleming, Lord Chancellor of Scotland since 1517, is assassinated by John Tweedie of Drummelzier (chief of Clan Tweedie) and others.source
- 1525February 24 – Battle of Pavia: German and Spanish forces under Charles de Lannoy and the Marquis of Pescara defeat the French army, and capture Francis I of France, after his horse is wounded by Cesare Hercolani. While Francis is imprisoned in Lombardy and then transferred to Madrid, the first attempts to form a Franco-Ottoman alliance with Suleiman the Magnificent against the Habsburg Empire are made.source
- 1525April 4 – German Peasants' War in the Holy Roman Empire: Battle of Leipheim – The peasants suffer great losses when they are attacked by Georg, Truchsess von Waldburg and the town of Leipheim is forced to surrender. Four peasant leaders are beheaded, including Jakob Wehe and Ulrich Schoen.source
- 1525May 14–15 – German Peasants' War: Battle of Frankenhausen – Insurgent peasants led by radical pastor Thomas Müntzer are defeated. Following the defeat, Müntzer is executed in front of the gates of Mühlhausen.source
- 1525June 23–24 – German Peasants' War: Battle of Pfeddersheim – Peasants are defeated in the last significant action of the war, in which over 75,000 peasants have been killed.source
- 1525Mixco Viejo, capital of the Pocomans Maya State, falls to the Spanish conquistadores of Pedro de Alvarado (in modern-day Guatemala) after a three-month siege.source
- 1526February 25 – The Battle of Hisar Firoza is fought in what is now the Indian state of Haryana, between the Mughal Empire (whose army is led by Prince Humayun) and the Delhi Sultanate, led by Hamid Khan. Humayun, in his first command, leads the Mughals to victory.source
- 1526March 6 – After a defeat in battle of Afghan soldiers of the Delhi Sultanate by the Mughal Empire, the Mughal Emperor Babur and Crown Prince Humayun arrange the execution of 100 captured Afghan prisoners by "blowing from a gun, the process of placing or tying a condemned prisoner to the mouth of a cannon and then firing.source
- 1526March 17 – King François I crosses from the Bidasoa River from Spain into France, while at the same time, his sons the Dauphin Prince François and Prince Henri, 8 and 5 at the time, cross into Spain to take his place as hostages to guarantee France's compliance with the Madrid Treaty. King François repudiates the treaty and the two boys remain captive for the next three years.source
- 1526April 21 – Battle of Panipat: Babur becomes Mughal emperor, invades northern India and captures Delhi, creating the Mughal Empire, which lasts until 1857.source
- 1526July 24 – Milan is captured by the Spanish.source
- 1526August 29 – Battle of Mohács: The Ottoman army of Sultan Suleiman I defeats the Hungarian army of King Louis II, who drowns while retreating with his troops. Two rival groups seek to elect a successor to Louis. Suleiman takes Buda, while Archduke Ferdinand of Austria and John Zápolya, Prince of Transylvania, dispute the succession. As a result of the battle, Ragusa achieves independence, although it acknowledges Ottoman overlordship.source
- 1526September 19 – Spanish Muslims who had hidden in the Sierra de Espadán mountain range in Valencia and who are led by Selim Almanzo are overwhelmed by a German contingent of 3,000 soldiers from the Holy Roman Empire. After their defeat, 5,000 adult Muslims (including old men and women) are massacred.source
- 1526December 15 – (12th day of 11th month of Daiei 6) The siege of Kamakura takes place in Japan as the Uesugi clan defeats the Hōjō clansource
- 1527February 21 – The Mughal–Rajput wars begin in India between the Emperor Babur of the Mughal Empire and states of the Rajput Confederacy, with the victory of the Rajput faction at the Battle of Bayana.source
- 1527March 17 – In India, the Battle of Khanwa is fought as the Mughal Emperor Babur defeats Rajput ruler Rana Sanga. This and two other major Moghul victories lead to their domination of northern India. Dhaulpur fort is taken by Babur.source
- 1527March 25 – The Confederation of Shan States sacks Ava, the capital of the Ava Kingdom.source
- 1527July 5 – General Div Sultan Rumlu, the regent for the 13-year old Tahmasp I, the Safavid Shah of Iran, is assassinated and replaced by Chukha Sultan Tekali.source
- 1527July 25 – The Battle of Sződfalva is fought near Szeged in what is now Hungary, with an army of Hungarians and Romanian Transylvanians defeating a Serbian army led by Jovan Nenad, the self-proclaimed Emperor of the Serbs. The next day, Nenad is assassinated for his failure in battle.source
- 1527September 27 – Battle of Tarcal: Ferdinand, future Holy Roman Emperor, defeats John Zápolya and takes over most of Hungary. John appeals to the Ottomans for help.source
- 1527October 5 – French and Venetian troops kill thousands of civilians in the Italian city of Pavia, even after the defenders agree to surrender.source
- 1527November 15 – The lands of the Bishopric of Utrecht, now in the Netherlands, are ceded to control of the Habsburgs in return for assistance in suppressing a rebellion by the citizens of Utrecht.source
- 1527The second of the Dalecarlian rebellions breaks out in Sweden.source
- 1528March 20 – The Battle of Szina is fought in the Kingdom of Hungary between the two rival kings, John Zápolya of Eastern Hungary and Archduke Ferdinand of Austria, the Habsburg King of Western Hungary. Zapolya and his 15,000-man army are defeated by mercenaries hired by the Habsburgs.source
- 1528March 22 – Siege of the southern Italian city of Melfi is started by the French Army, under the command of Marshal Odet of Foix, Viscount of Lautrec. After killing the defenders and pulling down the city walls, the French troops plunder what remains and massacre more than 3,000 men, women and children.source
- 1528April 28 – Battle of Capo d'Orso: The French fleet, under mercenary captain Filippino Doria, crushes the Spanish squadron trying to run the blockade of Naples.source
- 1528September 3 – The Kyōroku era begins in Japan, with the last day of the Daiei era ending on Daiei 8, 20th day of the 8th month.source
- 1528September 19 – War of the League of Cognac: The Italian city of Pavia is besieged for the fifth and last time during the decade, after having been attacked in 1522, 1524, 1527, and in May of 1528. Troops from a coalition of the Venetian Republic, the Kingdom of France and the Duchy of Milan break through the city walls after six days of bombardment, kill 700 of the defenders, and recover the city for Francesco II Sforza, Duke of Milan.source
- 1528Spain takes direct control of Acapulco.source
- 1528Peasant uprising in Dalarna, Sweden: The rebel campaign fails, and the rebel leader, later known as Daljunkern, flees to Rostock.source
- 1528Spanish Conquistador Francisco de Montejo attempts an invasion of the Yucatán, but is driven out by the Maya peoples.source
- 1529January 6 – Basarab VI is installed as the new Prince of Wallachia (now in Romania) in the capital at Târgoviște, days after the assassination of the Voivode Radu of Afumați by the other boyars (Wallachian nobles). Basarab's reign lasts only a month and he is removed on February 5.source
- 1529January 20 – In India, the Mughal Emperor Babur departs from the capital at Agra toward Ghazipur to fight the Rajputs and the rebel Afghans who had captured the city.source
- 1529March 9 – The Battle of Shimbra Kure is fought in Ethiopia as the Imam Ahmad ibn Ibrahim al-Ghazi, with 12,000 men, including special forces armed with matchlock firearms, defeats the 200,000 man army of the Emperor Dawit II.source
- 1529April 9 – The Westrogothian rebellion breaks out in Sweden.source
- 1529May 10 – The Ottoman army under Suleiman I leaves Constantinople, to invade Hungary once again.source
- 1529June 21 – War of the League of Cognac – Battle of Landriano: French forces in northern Italy are decisively defeated by Spain.source
- 1529September 8 – Buda is recaptured by the invading forces of the Ottoman Empire.source
- 1529September 27 – Vienna is besieged by the Ottoman Turks commanded by Suleiman the Magnificent.source
- 1529October 15 – With the season growing late, Suleiman abandons the Siege of Vienna (a turning point in the Ottoman wars in Europe).source
- 1530February 14 – Tangaxuan II, last cazonci of the Purépecha Empire, is executed by conquistador Nuño de Guzmán, ending the Purépecha Empire's independence from Spain.source
- 1530May 9 – The Kaqchikel people, a tribe of the Maya people of what is now the Sacatepéquez Department of Guatemala, surrender to the Spanish conquistadors.source
- 1530July 19 – Turkish Ottoman troops attempt to take the Hungarian town of Nagykörű but, according to local legend, the Turkish soldiers are lost in a marsh protecting the city.source
- 1530July 25 – The transfer of Tripoli, in North Africa, from Spain to the Knights of Malta, is formally accomplished, four months after an agreement was reached with Charles V, Holy Roman Emperor, King of Spain and King of Sicily.source
- 1530August 3 – Battle of Gavinana: Florence is captured by Spanish troops under Prince Philibert of Chalon (who is killed in the action). The Piagnon (followers of the memory of Girolamo Savonarola) are overthrown, ending the Siege of Florence, and the Medici are restored, in the person of the Pope's nephew Alessandro de' Medici.source
- 1530November 24 – Tabinshwehti succeeds his father Mingyi Nyo as king of the Toungoo dynasty, following the latter's death.source
- 1530December 26 – Humayun starts to rule the Mughal Empire after Babur's death.source
- 1530Austrian forces capture Esztergom, Hungary, and raid as far as Buda.source
- 1531February or March – Battle of Antukyah: Ahmad ibn Ibrahim al-Ghazi of the Adal Sultanate defeats the Ethiopian army.source
- 1531March 28 – In India, the fortress of Mandu, capital of the Malwa Sultanate, falls as Malwa's Sultan Mahmúd II and his sons surrender to Bahadur Shah of Gujarat.source
- 1531April 12 – In the Songhai Empire that rules most of West Africa and the Niger River valley, the Emperor Askiya Musa is assassinated by his brothers after less than two years on the throne. Askia Mohammad Benkan is enthroned the same day.source
- 1531April – Battle of Puná: Francisco Pizarro defeats the native inhabitants of the island of Puná, off of the coast of what is now the South American nation of Ecuador.source
- 1531May 18 – The third Dalecarlian rebellion in Sweden is settled on St. Eric's Day at Arboga in Denmark when King Christian II returns church bells, confiscated earlier to pay Denmark's debts, to the villages in rebellion.source
- 1531May 27 – (11th waxing of Nayon 893 ME) Minkhaung of Mrauk-U, the Burmese King of Arakan since 1521, is killed in a coup d'etat by the rebellious Governor of Thandwe, Min Pa.source
- 1531August 22 – Battle of Obertyn: The Moldavians are defeated by Polish forces under Jan Tarnowski, allowing the Poles to recapture Pokucie.source
- 1531October 11 – Battle of Kappel: The forces of Zürich are defeated by the Catholic cantons. Huldrych Zwingli, the Swiss religious reformer, is killed.source
- 1531October 28 – Battle of Amba Sel: Imam Ahmad ibn Ibrahim al-Ghazi again defeats the army of Dawit II, Emperor of Ethiopia. The southern part of Ethiopia thus falls under Imam Ahmad's control.source
- 1531November 5 – Christian II`s invasion force arrives in Oslo.source
- 1532April – Battle of Quipaipan in Peru: Atahualpa wins the civil war in the Inca Empire, defeating his brother Huáscar.source
- 1532June 25 – Suleiman the Magnificent leads another invasion of Hungary.source
- 1532August 5 – The siege of Güns in the Austrian Empire begins as the Ottoman army, under Sultan Suleiman the Magnificent, attempts to take the city of Güns (now Kőszeg in Hungary) with 100,000 troops in order to mount a larger invasion of the Austrian city of Vienna, capital of the Holy Roman Empire. The defenders, less than 800 Croatian soldiers commanded by Nikola Jurišić, puts up a successful resistance despite being outnumbered by more than 100 to 1.source
- 1532August 30 – The siege of Güns fails as heavy rains and the arrival of reinforcements from Charles V, Holy Roman Emperor to supplement the Croatian defenders, causes Suleiman to retreat.source
- 1532October 7 – (9th waxing of Tazaungmon 894 ME) The Burmese monarch Min Bin, King of Arrakan, leads a combined invasion force of 12,000 people (three armies of 11,000 men in a three-pronged attack, and a flotilla of war boats carrying 1,000 troops) in an invasion of Bengal in India.source
- 1532December 1 – (5th waxing of Pyatho 894 ME) The Burmese Army under Min Bin marches into Dhaka, capital of Bengal without any resistance.source
- 1532Possible date for the Battle of the Maule between Incas and Mapuches, according to historian Osvaldo Silva.source
- 1533September 13 – Antonio Sedeño, the Spanish Colonial Governor of Trinidad, comes under attack along with his troops by the Kalinago people, indigenous to the area. Though the Spanish lose many troops, Sedeño defeats the Kalinago and puts the island under Spanish rule.source
- 1534June 23 – Copenhagen opens its gates to Count Christopher of Oldenburg, leading the army of Lübeck (and the Hanseatic League), nominally in the interests of the deposed King Christian II of Denmark. The surrenders of Copenhagen and, a few days later, of Malmö represent the high point of the Count's War for the forces of the League. These victories presumably lead the Danish nobility to recognize Christian III as King on July 4.source
- 1534October 18 – Huguenots post placards all over France attacking the Catholic Mass, provoking a violent sectarian reaction (Affair of the Placards).source
- 1534December 4 – The Ottoman army under Suleiman the Magnificent captures the city of Baghdad from the Safavids without a struggle, beginning almost 400 years of Ottoman rule of what is now Iraq.source
- 1535March 23 – English forces under William Skeffington storm Maynooth Castle in Ireland, the stronghold of Thomas FitzGerald, 10th Earl of Kildare, after a siege that began on March 16. Skeffington shows little mercy to the 25 surviving defenders, and has them decapitated in front of the castle two days after the surrender.source
- 1535June 1 – The Conquest of Tunis by Charles V, Holy Roman Emperor, begins with the destruction of Barbarossa's fleet. Following the eventual capture of the city from the Ottoman Empire, around 30,000 inhabitants are massacred.source
- 1535June 8 – Battle of Bornholm: Combined Swedish and Danish fleets defeat the Hanseatic navy.source
- 1535June 24 – Münster Rebellion: The Anabaptist state of Münster is conquered and disbanded.source
- 1535July 6 – Sir Thomas More, author of Utopia and one time Lord Chancellor of England, is executed for treason, after refusing to recognize King Henry VIII as head of the English Church, and separate from the Roman Catholic Church.source
- 1535Spanish forces abandon the second attempted conquest of Yucatán.source
- 1535Mughal Emperor Humayun gives battle to Bahadur Shah of Gujarat.source
- 1536January 22 – John of Leiden, Bernhard Knipperdolling and Bernhard Krechting are executed in Münster for their roles in the Münster Rebellion.source
- 1536January 24 – King Henry VIII of England is seriously injured when he falls from his horse at a jousting tournament in Greenwich, after which the fully armored horse falls on him. The King is unconscious for two hours, sustaining an injury to an ulcerated leg and a concussion.source
- 1536March 8 – Pargalı Ibrahim Pasha, Grand Vizier of the Ottoman Empire since 1523, is executed after falling into disfavor with Hürrem Sultan, the wife of Ottoman Sultan Suleiman the Magnificent. After Hürrem persuades her husband that Pargali Ibrahim has become a threat as his money and power have increased, Suleiman hosts an elaborate dinner with Pargali as his guest. After the dinner ends, Pargali prepares to go to bed but is seized and strangled upon reaching his bedroom.source
- 1536March 14 – Ayas Mehmed Pasha is appointed by the Sultan Suleiman to be the new Grand Vizier of the Ottoman Empire.source
- 1536April 6 – Count's Feud: Malmø surrenders to King Christian III of Denmark.source
- 1536May 6 – Incan emperor Manco Inca Yupanqui, having on April 18 escaped from imprisonment in Cuzco, begins his revolt against his captors, when his army begins the 10-month Siege of Cuzco against a garrison of Spanish conquistadors and Indian auxiliaries, led by Hernando Pizarro.source
- 1536July 24 – Three days after the arrival of the peacekeeping team in Lyon, and 15 days after the legation had met with the Holy Roman Emperor to avoid war, troops of the Holy Roman Empire invade France, crossing over the Var river from Nizza in Italy (now Nice in France) as well as invading Picardie with a second force.source
- 1536July 29 – The Count's Feud ends when Copenhagen surrenders to King Christian III of Denmark. On August 6 he marches into the city and on August 12 arrests the country's bishops, thus consolidating the Protestant Reformation in Denmark.source
- 1536August 5 – Guelders Wars: Battle of Heiligerlee – Danish allies of Charles II, Duke of Guelders, under command of Meindert van Ham, are defeated by Habsburg forces under Georg Schenck van Toutenburg in the Low Countries.source
- 1536October 1 – The Pilgrimage of Grace, a rebellion in England against Henry VIII's church reforms, begins in Lincolnshire and spreads across the kingdom to most of Yorkshire, and parts of Northumberland, Durham, Cumberland and Westmorland.source
- 1536October 10 – English barrister Robert Aske becomes the leader of the Pilgrimate of Grace rebels, whose numbers have grown to 9,000 and marches with them to York.source
- 1536Battle of Reynogüelén: Spanish conquistadors defeat a group of Mapuches in Chile, during the expedition of Diego de Almagro.source
- 1536Battle of Un no Kuchi: Takeda Family forces defeat Hiraga Genshin.source
- 1537January 6 – Alessandro de' Medici, Duke of Florence is assassinated by Lorenzino de' Medici, a distant cousin, who claims that he wants to reintroduce republican rule but has to flee to Venice. Instead Cosimo I of the junior branch of the Medici becomes the new duke.source
- 1537January 16 – Bigod's Rebellion, an uprising by Roman Catholics, led by Francis Bigod against Henry VIII of England and Protestant Rebellion, begins with an unsuccessful attempt to seize Scarborough Castle in Yorkshire.source
- 1537January 19 – Most of Bigod's forces are captured by the English Army at a dawn raid of their camp at Beverley, Yorkshire, but Bigod escapes to Mulgrave and then to what is then the County of Cumberland.source
- 1537January – At the battle of Ollantaytambo, the Inca Emperor Manco Inca Yupanqui defeats the Spanish led by Hernando Pizarro and the Spaniards' Indian alliessource
- 1537February 10 – Francis Bigod, leader of Bigod's rebellion is captured at Cumberland by the English Army and imprisoned at Carlisle Castle. He is hanged at Tyburn on June 2.source
- 1537April 18 – Diego de Almagro successfully charges Manco Inca's siege of Cuzco, thereby saving his antagonists, the Pizarro brothers.source
- 1537April 20 – Spanish conquest of the Muisca: Bacatá, the main settlement of the Muisca Confederation, is conquered by Gonzalo Jiménez de Quesada, effectively ending the Confederation in the Colombian Eastern Andes.source
- 1537May 17 – The Ottoman Empire invaded southern Italy, attacking the cities of Apulia, Otranto and Brindisi, in a campaign that would last until November 22.source
- 1537July 12– Rodrigo Orgóñez occupies and sacks the Inca center of Vitcos at the battle of Abancay, but Manco Inca Yupanqui escapes and establishes the independent Neo-Inca State elsewhere in Vilcabamba, Peru.source
- 1537July 23 – The third Ottoman–Venetian War begins as the Ottoman Sultan Suleiman the Magnificent leads an invasion of the Republic of Venice. The war will continue until October 2, 1540.source
- 1537August 2 – The battle of Montemurlo, an attempt by residents of the former Republic of Florence to overthrow Cosimo I de' Medici, Duke of Florence and restore the republican government, ends in failure. The Medici family then takes revenge on the supporters of the Republic, including the Republic commander, General Piero Strozzi.source
- 1537August 25 – The Honourable Artillery Company, the oldest surviving regiment in the British Army, and the second most senior, is formed.source
- 1537August 26–The siege of the island of Corfu is started by the Ottoman Empire Navy, commanded by Suleiman the Magnificent. Suleiman abandons the siege in September after an outbreak of plague, and the Ottoman troops return home.source
- 1537November 1 – In what is now the Central American nation of Honduras, the Spanish conquistadore Alonso de Cáceres arrives at the Peñol de Cerquín, the mountaintop fortress of King Lempira of the Lencas, the indigenous leader of the resistance against European rule. Cáceres sends envoys to request Lempira to surrender. In response, Lempira has the Spanish messengers executed.source
- 1538April 26 – Battle of Las Salinas: In Peru, Almagro is defeated by Francisco Pizarro, who then seizes Cusco.source
- 1538September 28 – Battle of Preveza: The Ottoman fleet of Suleiman the Magnificent, under the command of Hayreddin Barbarossa, defeats the Holy League of Emperor Charles V, under the command of Andrea Doria.source
- 1538November 5 – The siege of the Indian city of Diu ends as the Gujarat and Ottoman forces withdraw from the Portuguese held city.source
- 1539January – Toungoo–Hanthawaddy War – Battle of Naungyo, Burma: The Toungoos decisively defeat the Hanthawaddys.source
- 1539May 30 – Hernando de Soto lands at Tampa Bay, Florida with 600 soldiers, with the goal of finding gold. He also introduces pigs into North America.source
- 1539June 26 – Battle of Chausa in modern-day Buxar, India: Sher Shah Suri defeats the Mughal emperor, Humayun (Sher Shah goes on to form the Sur Empire, and take control of nearly all Mughal territory).source
- 1539July 18 – The siege of Castelnuovo (now the town of Herceg Novi in Montenegro) is started by General Hayreddin Barbarossa, leader of the Ottoman Empire's Army, after the Spanish commanding officer, Francisco de Sarmiento, rejects an offer of honorable surrender with safe passage. Spain had taken the city in war from the Ottomans in 1538, giving the Christian Europeans control of the eastern Mediterranean sea and access to the Holy Land. With 50,000 Ottomans against less than 4,000 Spanish defenders, Castelnuovo falls in less than three weeks.source
- 1539August 17 – The revolt of Ghent begins in the Spanish Netherlands (now Belgium) as members of the city's guilds demand the right to choose their own leaders, and the resignation of the Spanish-sponsored city leaders. Within four days, the city is under the control of nine guild leaders.source
- 1539December 15 – In the Spanish colony of Nueva Granada (now the Republic of Colombia, Spanish conquistador Baltasar Maldonado and his troops fight a final battle at Duitama (now the Boyacá Department) against the indigenous armies of the Muisca Confederation, led by Tundama.source
- 1540February 14 – Charles V, Holy Roman Emperor, enters Ghent without resistance, and executes rebels, ending the Revolt of Ghent (1539–1540).source
- 1540May 17 – Battle of Kannauj: Sher Shah Suri defeats and deposes Mughal Emperor Humayan, establishing the Sur Empire.source
- 1540July 28 – Thomas Cromwell, is executed for treason publicly in London on the orders of king Henry VIII of England. Henry marries his fifth wife, Catherine Howard, on the same day.source
- 1540September 10 – Gibraltar is sacked by the fleet of Barbary pirate Ali Hamet, a Sardinian renegade in the service of the Ottoman Empire, and many of its leading citizens are taken as captives to Peñón de Vélez de la Gomera in Morocco. This leads to construction of the defensive Charles V Wall, at this time known as the Muralla de San Benito.source
- 1540October 1 – Battle of Alborán: A Habsburg Spanish fleet, under the command of Bernardino de Mendoza, destroys an Ottoman fleet commanded by Ali Hamet off Alborán Island in the Mediterranean.source
- 1540December 20 – Stephen V, Prince of Moldavia, is assassinated by two of the Moldavian nobles (boyars), Mihul and Trotsanul, after word arrives that he will be replaced by Petru Rareş, who had paid a bribe to the Ottoman Sultan Suleiman in order to be appointed the new Prince. Alexandru Cornea is crowned temporarily as Prince Alexandru III.source
- 1541March 8 – At the Battle of Suakin, fought at an Ottoman port city on the Red Sea in what is now Sudan, Portuguese General Estêvão da Gama and his brother Cristóvão da Gama lead an attack against the Ottoman ruler and plunder the city.source
- 1541March 12 – The Portuguese Empire's fortress at Agadir falls to the Moroccan general Mohammed al-Shaykh after a siege of 24 days.source
- 1541April 24 – Battle of Sahart: Gelawdewos is defeated by the forces of Imam Ahmad ibn Ibrahim al-Ghazi.source
- 1541June 16 – Şehzade Mustafa, the son of the Ottoman Sultan Suleiman the Magnificent, is appointed as the new Ottoman Governor of the Amasya region of Turkey.source
- 1541June 26 – At Lima, Francisco Pizarro, the Spanish conqueror of the Inca Empire of Peru and Governor of Nueva Castilla since 1529, is assassinated by 20 heavily-armed supporters of Diego de Almagro II in retaliation for the 1538 execution of Diego de Almagro.source
- 1541July 9 – Estêvão da Gama departs Massawa, leaving behind 400 matchlock men and 150 slaves under his brother Cristóvão da Gama, with orders to assist the Emperor of Ethiopia to defeat Ahmad ibn Ibrahim al-Ghazi, who had invaded his Empire.source
- 1541September 28 – King Charles of Spain begins the disastrous campaign against the Regency of Algiers as he assembles a fleet of 500 ships, with 24,000 soldiers, at the Spanish island of Majorca and prepares to cross the Mediterranean with the fleets of allied nations led by the Admiral Andrea Doria of the Republic of Genoa.source
- 1541October 7 – Through royal decree, the city of Arequipa is granted its coat of arms.source
- 1541November 19 – (1st waxing of Tazaungmon 903 ME) King Tabinshwehti of Burma, having concluded the Buddhist Lent, leads the attack on the Kingdom of Prome with 17,000 troops and 1,400 boats.source
- 1541November 23 – Charles V, Holy Roman Emperor, who also serves as King Carlos I of Spain, is finally able to depart from Algiers and abandons his army.source
- 1542February 2 – Battle of Baçente: The Portuguese under Cristóvão da Gama capture a Muslim-occupied hillfort in northern Ethiopia.source
- 1542March 8 – Antoine Escalin des Eymars, the French ambassador, returns from Constantinople, with promises of Ottoman aid in a war against Charles V, Holy Roman Emperor.source
- 1542April 4 – The Battle of Jarte begins in Ethiopia as the Army of the Portuguese Empire, commanded by Cristóvão da Gama encounters the army of the Ethiopian ruler, the Imam Ahmad ibn Ibrahim al-Ghazi, achieving a victory on April 16.source
- 1542May 19 – The Prome Kingdom, in modern-day central Burma, is conquered by the Taungoo Dynasty.source
- 1542July 23 – (10th day of 6th month of Tenbun 11) In Japan, a six-year rebellion within the Date clan when clan leader Date Tanemune, returning home from a day of falconry, is attacked by his oldest son, Date Harumune, and imprisoned at Kōri-Nishiyama Castle in Fukushima Prefecture. Tanemune is rescued by an aide, Koyanagigawa Munetomo, and escapes. The war lasts for six years before Harumune triumphs and becomes the new leader of the Date clan.source
- 1542July 24 – Guelders Wars: Maarten van Rossum leaves Antwerp, having failed to take it by siege.source
- 1542August 24 – Battle of Haddon Rig: Scotland defeats England.source
- 1542August 28 – Battle of Wofla in Ethiopia: Reinforced with at least 2900 arquebusiers and cavalry, the Imam Ahmed ibn Ibrahim al-Ghazi attacks the Portuguese camp. The Portuguese are scattered; Cristóvão da Gama is captured and executed.source
- 1542November 24 – Battle of Solway Moss: An English army invades Scotland, and defeats a Scottish army.source
- 1543February 21 – Battle of Wayna Daga: A joint Ethiopian-Portuguese force of 8,500, under Emperor Gelawdewos of Ethiopia, defeats Imam Ahmad ibn Ibrahim al-Ghazi's army of over 14,000, ending the Ethiopian–Adal War.source
- 1543March 7 – Abu Abdallah Muhammad VI is installed as the new ruler of the Kingdom of Tlemcen in modern-day Algeria, succeeding his brother Abu Zayyan III.source
- 1543March 20 – King Gustav of Sweden leads troops in troops crushing Dacke's Rebellion, led by Swedish peasant Nils Dacke, with defeat coming at the Battle of Hjortensjon.source
- 1543April 23 – Suleiman the Magnificent, Sultan of the Ottoman Empire, follows up on his 1541 annexation of Hungary by invading a second time to capture areas that had been taken by Archduke Ferdinand, including Esztergom.source
- 1543June 4 – Fabiano di Monte San Savinov leads 500 infantry men and some cavalry in an attempt to conquer the Republic of San Marino, but the group fails after getting lost in a dense fog on Saint Quirinus' Day.source
- 1543June 22 – King Henry VIII of England declares war on King Francis I of France, one month after sending an ultimatum.source
- 1543July 25 – The first large naval battle in the Atlantic Ocean, the Battle of Muros Bay, takes place off of the coast of Galicia in Spain between the French fleet and the Spanish fleet. Although France has the larger force, the Spanish Admiral Álvaro de Bazán identifies the flagship of French Admiral Jean de Clamorgan and sinks the vessel. Spain then captures the remaining 23 other ships and takes 3,000 prisoners, while France loses 3,000 dead and injured.source
- 1543July 25 – Suleiman the Magnificent, the Ottoman Sultan, begins the siege of the city of Esztergom in Hungary.source
- 1543August 6– The Siege of Nice by the Ottoman Empire and French forces (under the Franco-Ottoman alliance), led by Admiral Hayreddin Barbarossa, begins. At the time, the city is under the control of the Duchy of Savoy and is defended by the Savoyards, assisted by the Habsburg armies of Spain and the Holy Roman Empire. The siege lasts for 16 days.source
- 1543August 10 – Esztergom surrenders to the Ottomans led by Suleiman the Magnificent.source
- 1543August 22– The city of Nice is captured by the Ottomans and Barbarossa after a long bombardment. The Ottomans pillage the city and take away 2,500 captives to be sold into slavery.source
- 1543August 25 – (24th day of 7th month of Tenbun 12) The first Europeans arrive in Japan and introduce firearms to the Asian monarchy, as the Chinese pirate Wang Zhi escorts Portuguese traders to in Tanegashima island in southern Kyushu. The first European visitors include António Mota, António Peixoto, Francisco Zeimoto, and Fernão Mendes Pinto.source
- 1543September 4 – Campaign of Suleiman: Suleiman the Magnificent captures the Hungarian coronation city of Székesfehérvár after a siege that had started on August 20. The city will be occupied by the Ottoman Empire for 145 years.source
- 1543September–October – Landrecies in Picardy is besieged by forces under Charles V, Holy Roman Emperor, but the siege is withdrawn on the approach of the French army.source
- 1543October 6 – In order to aid James Hamilton, Earl of Arran, Regent of Scotland, in his defense against challenger Matthew Stewart, 4th Earl of Lennox, King Francois of France arranges for two envoys, Jacques de La Brosse and Jacques Ménage to deliver money and munitions to Dumbarton Castle. The envoys unwittingly deliver Arran's materials to Lennox.source
- 1543November 16 – Suleiman, Sultan of the Ottoman Empire, completes his campaign to bring Hungary under Ottoman rule, having captured Esztergom, Székesfehérvár, Siklós and Szegedsource
- 1543December 7 (11 waxing of Natdaw 905 ME) – The land and naval forces of the Confederation of Shan States (consisting of the principalities of Mohnyin, Mogaung, Bhamo, Momeik and Kale), led by Prince Sawlon of Mohnyin and King Hkonmaing, depart from the Shan capital, Awa, to start an invasion of the Toungoo Empire in upper Myanmar. The invaders easily overrun Toungoo and its capital at Prome a week later.source
- 1543December 20 – The Eight Years War, also called the "War of Rough Wooing", begins as Scotland's Parliament votes to declare war on the Kingdom of England.source
- 1543December 31 – King Henry VIII of England signs an agreement with Charles V, Holy Roman Emperor to invade France by June 20, 1544 with at least 35,000 infantry and 7,000 cavalry.source
- 1544January 4 – In India, Maldeo Rathore, King of Marwar (now part of the state of Rajasthan) is tricked by counterintelligence spread by Mughal Emperor and Afghan Shah Sher Shah Suri into departing from Jodhpur. The Battle of Sammel begins shortly afterward and is won by the Afghan and Mughal armies.source
- 1544March 16 – The Battle of Glasgow is fought for control of Scotland between Matthew Stewart, 4th Earl of Lennox and the troops of the Regent, James Hamilton, 2nd Earl of Arransource
- 1544April 11 – Battle of Ceresole: French forces under the Comte d'Enghien defeat forces of the Holy Roman Empire, under the Marques Del Vasto, near Turin.source
- 1544May 3 – Edward Seymour, Earl of Hertford, with an English army, captures Leith and Edinburgh from the Kingdom of Scotland.source
- 1544May 25 – On orders of King Henry VIII, the English Navy, commanded by Thomas Howard, 3rd Duke of Norfolk, begins crossing the English Channel to invade from the west with 19,000 troops, while Charles V, Holy Roman Emperor, commences an invasion of France from the east.source
- 1544June 4 – A combined force of troops from the Holy Roman Empire and from Spain, both commanded by Emperor Charles V, defeat the French in the Battle of Serravalle after three days of fighting.source
- 1544June 8 – The Duke of Norfolk crosses the English Channel after having landed troops in Normandy.source
- 1544June 24 – The plundering of the Italian island of Ischia, part of the Kingdom of Naples is carried out by the Ottoman Empire Navy, commanded by Hayreddin Barbarossa, who captures 4,000 of the residents and then sells them as slaves in Algeria.source
- 1544July 10– Troops of the Holy Roman Empire begin the six-week siege of Saint-Dizier in eastern France.source
- 1544July 15 – Battle of the Shirts: The Clan Fraser of Lovat and Macdonalds of Clan Ranald fight over a disputed chiefship in Scotland; reportedly, five Frasers and eight or ten Macdonalds survive.source
- 1544July 19– Italian War of 1542–46: King Henry VIII of England begins the siege of the city of Boulogne in northern France and continues for almost two months before the city surrenders.source
- 1544August 17 – In France, Saint-Dizier surrenders to the Holy Roman Empire after a siege of more than a month.source
- 1544September 14 – The siege of Boulogne ends as the city surrenders to King Henry VIII.source
- 1544October 9 – Second Siege of Boulogne: French forces under the Dauphin assault Boulogne, but are ultimately unsuccessful.source
- 1545February 27 – Battle of Ancrum Moor: The Scots are victorious over numerically superior English forces.source
- 1545March 17 – Mircea the Shepherd enters Bucharest as the new ruler of Wallachia, now in Romania.source
- 1545May 31 – During the Italian War, a French expeditionary force under the direction of Claude d'Annebault begins an invasion of Britain by landing in Scotland.source
- 1545July 18– The Battle of the Solent begins between the English and French navies in The Solent, the strait between the British mainland and the Isle of Wight.source
- 1545July 21 – Italian Wars: Battle of Bonchurch – The English reverse an attempted French invasion of the Isle of Wight, off the coast of England.source
- 1545September 16 – In a one-day campaign in the Rough Wooing border war between England and Scotland, the English generals Lord Hertford and Robert Bowes carry out a mission of burning Scottish towns along the River Teviot. He writes later that with 1,500 light horsemen from 5:00 in the morning to 3:00 in the afternoon, his army "burnt 14 or 15 towns" including "Rowle, Spittel, Bedrowle, Rowlewood, The Wolles, Crossebewghe, Donnerles, Fotton, West Leas, Troonyhill, and Dupligi.source
- 1545October 31 – (26th day of 9th month of Tenbun 14) The Siege of Kawagoe Castle begins, as part of an unsuccessful attempt by the Uesugi clan to regain Kawagoe Castle from the Late Hōjō clan in Japan.source
- 1545November 10 – A truce is signed between the Holy Roman Empire and the Ottoman Empire following the Siege of Nice, as Emperor Charles V acknowledges the Ottoman conquests.source
- 1545November 15 – (10 Ramadan 952 AH) Hamida Banu Begum, Empress consort of India's Mughal Empire and wife of the Emperor Humayun, returns to the capital, Agra, after a three-year absence. She is accompanied by an army provided to Humayun by Tahmasp I, Shah of Iran.source
- 1545c. September – Mobye Narapati succeeds as ruler of the Ava Kingdom and offers peace to the Taungoo dynasty, ending the Taungoo–Ava War (1538–45), and leaving the Taungoo as the dominant rulers in Burma.source
- 1545Battle of Sokhoista: The army of the Ottoman Empire defeats an alliance of Georgian dynasties.source
- 1546January 11 – (Tenbun 15, 20th day of the 12th month): Ashikaga Yoshifushi becomes 13th Shōgun of the Ashikaga shogunate.source
- 1546January 18 – Blasco Núñez Vela first Spanish Viceroy of Peru fights with Gonzalo Pizarro at the Battle of Iñaquito and is killed.source
- 1546March 1 – Scottish Protestant reformer George Wishart, arrested on January 19, is burned at the stake at St Andrews on orders of Cardinal David Beaton of the Roman Catholic church, after being found guilty of heresy. Cardinal Beaton is assassinated less than three months later.source
- 1546April 20 – The Siege of Diu begins as the Gujarat Sultanate, led by Mahmud Shah III attacks the Portuguese colonial fortress at Diu. Reinforcements arrive on July 19 and Governor Castro arrives with 3,000 soldiers on November 7. The keeper of the King's Ports and Galley siege lasts until November 10 and ends with a Portuguese victorysource
- 1546May 19 – The Siege of Kawagoe Castle ends in defeat for the Uesugi clan, in their attempt to regain Kawagoe Castle from the Late Hōjō clan in Japan.source
- 1546July 8 – the Earl of Arran, Regent of Scotland for Mary, Queen of Scots recaptures Dumbarton Castle from England after a 20-day siege.source
- 1546July 10 – The Schmalkaldic War begins with an attack by the Protestant German states against the town of Füssen, a village of the Prince-Bishopric of Augsburg in Bavaria.source
- 1546August 24 – Mircea the Shepherd, ruler of the Principality of Wallachia (now Romania) stages a surprise attack in the Battle of Periș and decimates the members of the Wallachian nobility (boyars) who oppose his rule.source
- 1546August 28 – In the Imperial counterattack in the Schmalkaldic War, the Holy Roman Empire army attacks Frankfurt, the German stronghold of the Schmalkaldic League, but is forced to retreat after a two-day siege.source
- 1546October 8 – The Fourteen of Meaux, French Huguenots found guilty of heresy for practicing the Protestant faith and rejecting Catholicim, are burned at the stake in front of the ruins of the first Reformed Church of France.source
- 1546October 28 – (4th waxing of Tazaungmon 908 ME) A second campaign begins in the Toungoo–Mrauk-U War in what is now the Asian nation of Myanmar, as King Tabinshwehti of Burma starts an invasion of the Kingdom of Mrauk U (led by Min Bin) in the Arakan Mountains. King Tabinshwehti dispatches 19,000 troops, 400 horses, and 60 elephants, with 4,000 invading by land and the other 15,000 being transported on a fleet of 800 war boats, 500 armored war boats, and 100 cargo boats through the Bay of Bengal to the coast of Mrauk U.source
- 1546November 8 – (5 Cimi 19 Xul, Mayan calendar) An uprising by the Maya civilization against the Spanish colonial administrators of New Spain begins in the Yucatan area of Mexico, with simultaneous attacks at Mérida, Valladolid, and Bacalar. The attack comes from seven Mayan provinces on the Gulf of Mexico, Cupul, Cochuah, Sotuta, Tases, Uaymil, Chetumal, and Chikinchel. The rebellion is suppressed by March and the instigators are arrested and executed.source
- 1546December 18 – A truce is agreed to between the Kingdom of Scotland (led by the Regent Arran) and the "Catilians", a group of Scottish Protestants who have been holding St Andrews Castle since their May 29 assassination of Cardinal David Beaton. With England's King Henry VIII threatening an invasion to protect the Protestant Castilians, the parties agree that no action will be taken until the Pope can consider whether to absolve the Protestants of murder, and that if the Pope grants the absolution, the Protestants will be allowed to surrender on good terms.source
- 1546The Spanish conquest of Yucatán is interrupted by an uprising of the Eastern Provinces of the completed in November, but the conquest is completed by March of 1548.source
- 1547April 24 – Battle of Mühlberg: Emperor Charles V defeats the Lutheran forces of the Schmalkaldic League and takes John Frederick I.source
- 1547May 23 – The Protestant Schmalkaldic League defeats the Catholic Army of the Holy Roman Empire at the Battle of Drakenburg. Of 6,000 Imperial troops, 2,500 are killed and another 2,500 are taken prisoner by the Protestants.source
- 1547June 13 – A peace treaty is signed between representatives of the Holy Roman Empire and of the Ottoman Empire and France after the Holy Roman Empire's defeat at the 1543 Siege of Nice.source
- 1547June 23 – Philip I, Landgrave of Hesse and John Frederick I, Elector of Saxony, leaders of the Schmalkaldic League who were both captured at the battle of Muhlberg, are transported to south Germany and imprisoned for their revolt against the Empire.source
- 1547June 26 – King Henri of France orders the division of France's easternmost provinces and divides them into three zones of control, each administered by a Marshal of the Army.source
- 1547June 29 – A fleet of 21 French galleys, commanded by Leone Strozzi, arrives at Fife in Scotland and begins the siege of St Andrews Castle.source
- 1547September 10 – Battle of Pinkie Cleugh: An English army under the Duke of Somerset, Lord Protector of England, defeats a Scottish army under James Hamilton, 2nd Earl of Arran, the Regent. The English seize Edinburgh.source
- 1547October 13 – (New Moon of Thadinovut 909 ME) With the end of the Buddhist Lent, the Kingdom of Burma (now Myanmar) mobilizes to invade the Kingdom of Arakan (now Thailand).source
- 1547November 15 – A fleet of 60 Ottoman Navy ships, commanded by Piri Reis, arrives at the port of Aden (now in Yemen) and captures the city in slightly more than three months, by February 26, 1548.source
- 1547December 6 – The Battle of Perlis River is fought between the Portuguese Navy and the navy of the Aceh Sultanate (now a province of Indonesia) at the Perlis River in Malaysia. With nine light warships and 230 soldiers, the Portuguese sink or capture 45 of the 60 ships of Aceh vessel leave 4,000 of their 5,380 soldiers dead or missing.source
- 1547December 28 – Sir John Luttrell of England, recently victorious over Scotland in the Battle of Pinkie, raids the Scottish port of Burntisland on the Firth of Forth, after his uncle Thomas Wyndham brings two Royal Navy warships. Luttrell and Wyndhamburn ships and buildings on the pier and capture Rossend Castlesource
- 1547Edward VI of England outlaws execution by boiling.source
- 1548January 19 – Three ships from the Portuguese Navy arrive at the port of Aden to assist Mohammed bin Ali al-Tawlaki, who has been defending the city against an attack by the Ottoman Navy. The Portuguese ships are forced to retreat to Zeila in Somalia, where 120 survivors are captured and their ships are burned.source
- 1548January 28 – (Tenbun 17, 30th day of 12th month) Nagao Kagetora (later Uesugi Kenshin) leads a triumphant entry into Kasugayama Castle in Japan, replacing his older brother Nagao Harukage as the lead samurai in the Nagao clan that rules the Echigo Province.source
- 1548February 2 – On Candlemas day in Scotland, during the Rough Wooing War with England, the Byllye Castle near Auchencrow is captured by a force of 11 English soldiers led by Thomas Carlile, and becomes a garrison for English troops.source
- 1548February 14 – (Tenbun 18, 4th day of 1st month) At the Battle of Uedahara, firearms are used for the first time on the battlefield in Japan, and Takeda Shingen is defeated by Murakami Yoshikiyo.source
- 1548February 26 – The Ottoman Navy, led by Admiral Ahmed Muhiddin Piri (commonly known as Piri Reis), recaptures Aden.source
- 1548May 15 – Ratan Singh of Amber, Raja of the Amber Kingdom in what is now the Indian state of Rajasthan, is poisoned by his younger brother Askaran, Raja of Narwar.source
- 1548June 1 – Bharmal becomes the new raja of the Kingdom of Amber, in territory now occupied by India's Rajasthan state, upon the overthrow of his nephew, Askaran, Raja of Narwar, who had reigned for only 16 days.source
- 1548June 1 – The Japanese city of Uchiyama in Shinano Province (now in the Nagano Prefecture) is burned by the clan of Murakami Yoshikiyo after the February defeat of the Takeda clan at the Battle of Uedahara.source
- 1548June 11 – Suleiman the Magnificent, the Sultan of the Ottoman Empire begins an invasion of Safavid Iran that will last for almost two years before he abandons it.source
- 1548June 16 – The first of 8,000 French troops under the command of General André de Montalembert arrive at the port of Leith at the invitation of the King of Scotland, who seeks to drive out the occupying forces of the Army of England.source
- 1548November 11 – Worawongsathirat, ruler of the Ayutthaya Kingdom of Thailand after usurping the throne on June 10, stages his coronation along with his wife, Si Sudachan. Both husband and wife had after both conspired to murder her son, King Yofta, in June. The King and Queen are assassinated on January 13, 1549.source
- 1548December – Siam attacks Tavoy, beginning the Burmese–Siamese War of 1548.source
- 1548Ming Chinese naval forces commanded by Zhu Wan destroy the pirate haven of Shuangyu, frequented by Chinese, Japanese and Portuguese smugglers.source
- 1549January 11 – An uprising of the Diaguitas natives outside of the South American Spanish colonial city of La Serena (now in Coquimbo province of Chile) begins. Within a day, the South American village is burned down and nearly every Spanish resident is killed.source
- 1549January – Burmese–Siamese War (1547–49): King Tabinshwehti of Burma begins his invasion of the Ayutthaya Kingdom, which ends in retreat.source
- 1549February 3 – Burmese–Siamese War: Burmese viceroy Thado Dhamma Yaza I of Prome slays Sri Suriyothai, queen consort of the Ayutthaya Kingdom, on her war elephant, when she intervenes in battle to protect the life of her husband.source
- 1549May 15 – King Henri II of France makes a triumphant return to Paris after suppressing the Revolt of the Pitauds in Bordeaux.source
- 1549June 9 – The Book of Common Prayer is introduced in English churches; the Prayer Book Rebellion against it breaks out in the West Country.source
- 1549June 19 – In the war of the Rough Wooing between Scotland and England, a Scottish and French force commanded by André de Montalembert retakes the island of Inchkeith, killing more than 300 soldiers from the English Army.source
- 1549July 8 – Kett's Rebellion, with 18,000 troops led by Robert Kett, breaks out at Wymondham in East Anglia, against fences and enclosures put up by wealthy landowners. and in Oxfordshire, against landowners associated with religious changes.source
- 1549July 18 – (Tenbun 18, 24th day of the 7th month) In the Battle of Eguchi, fought in Japan's Settsu Province near Osaka, General Miyoshi Nagayoshi defies the Governor, Hosokawa Harumoto, to attack the Eguchi Castle of Nagayoshi's cousin, Miyoshi Masanaga. After a 12-day battle, Miyoshi Masanaga is killed along with several of Hosokawa's other generals. Governor Hosokawa, fearing a reprisal, flees and eventually loses his authority over Settsu Province.source
- 1549July 29 – Norwich, in Norfolk falls to Kett's rebels.source
- 1549August 1– Kett's rebels defeat a Royal Army led by William Parr, Marquess of Northamptonsource
- 1549August 8– England and France declare war.source
- 1549August 17 – Battle of Sampford Courtenay in England: The Prayer Book Rebellion is quashed.source
- 1549August 27 – At the Battle of Dussindale in England, Kett's Rebellion is ended by troops led by John Dudley, 1st Duke of Northumberland.source
- 1549September 19 – The English Army abandons Haddington, East Lothian as it continues its retreat from Scottish and French forces.source
- 1549December 7 – Robert Kett is hanged from the walls of Norwich Castle after being found guilty of treason for leading Kett's Rebellion. His brother William is hanged from the walls of Wymondham Abbey on the same day.source
- 1549December 21 – Ottoman Empire Sultan Suleiman the Magnificent abandons his campaign against Safavid Iran after 21 months, during which he was unable to proceed further than Tabriz.source
- 1549Siege of Kajiki: firearms are used for the first time in a siege in Japanese history. (The previous year's Battle of Uedahara was the first battle in which they were used.)source
- 1550February 25 – (10th day of 2nd month of Tenbun 19) In Oita, Ōita Prefecture, an attack within the Ōtomo clan of Japanese samurai takes place after clan leader Ōtomo Yoshikazu seeks to disinherit his oldest son and to make his third son, Ōtomo Shioichimaru, as his designated successor. Supporters of the oldest son, Ōtomo Yoshishige, invade Yoshikazu's home and kill Shioichimaru and four other family members.source
- 1550March 12 – Arauco War: Battle of Penco – Several hundred Spanish and indigenous troops under the command of Pedro de Valdivia defeat an army of 60,000 Mapuche in modern-day Chile.source
- 1550April 30 – King Tabinshwehti of Burma is assassinated by two of his bodyguards while he is on a hunting trip. The two swordsmen, sent by Smim Sawhtut, Governor of Sittaung, behead the King, and a civil war begins as major governors rebel against the new Burmese King Bayinnaung.source
- 1550May 20 – The Spanish Catalan city of Cullera is plundered by the Ottoman Empire General Dragut Reis, and most of its inhabitants are sold into slavery in Algeria.source
- 1550June 28 – Capture of Mahdia (1550): The Spanish Armada arrives in North Africa to begin the process of capturing the fortress of Mahdia (now in Tunisia) from control of the Ottoman Empire.source
- 1550July 25 – Capture of Mahdia (1550): Troops commanded by Ottoman General Turgut Reis make a counterattack on the Spanish invaders, led by General Andrea Doria. Both sides sustain heavy losses, and the Spanish succeed in forcing the Ottomans to retreat back inside Mahdia.source
- 1550September 2 (5th waning of Tawthalin 912 ME) – King Bayinnaung of Burma begins a four-month siege of the former Burmese capital, Toungoo, occupied by the king's rebellious brother Minkhaung.source
- 1550September 10 – Spanish troops, commanded by Genoa's General Andrea Doria, capture the Tunisian fortress of Mahdia from the Ottoman Empire after fighting that began on June 28.source
- 1550October 2 – Battle of Sauðafell in Iceland: Daði Guðmundsson of Snóksdalur defeats the forces of Catholic Bishop Jón Arason, resulting in Iceland becoming fully Protestant. Arason is captured; he is executed, along with his two sons, on November 7.source
- 1550December 29 – Bhuvanaikabahu VII, King of Kotte on most of the island of Sri Lanka, is assassinated by a gunman hired by the government of Portuguese India.source
- 1551January 11 (5th waxing of Tabodwe 912 ME) – King Bayinnaung of Burma is successful in capturing his ancestral city of Toungoo from his rebellious half-brother Minkhaung II, and sets about to make Toungoo the capital for the first time since 1539. Minkhaung is forgiven by King Bayinnaung rather than being executed, and assists in the King's campaign to capture the neighboring Kingdom of Prome.source
- 1551May 27 – Italian War of 1551–1559: A defensive alliance, placing the Duchy of Parma and Piacenza under the protection of France, is signed between representatives of King Henry II of France and Ottavio Farnese, Duke of Parma, placing Parma under French protection.source
- 1551July 18 – Invasion of Gozo: Ottoman Turks and Barbary pirates invade the Mediterranean island of Gozo (now part of Malta), and enslave almost all of its 6,000 inhabitants.source
- 1551July 30 – With the surrender of the island of Gozo, the Ottoman place 6,000 survivors on ships and transporting them to Tarhuna Wa Msalata (in modern-day Libya), where they are sold into slavery. The only natives left on the island are 300 persons who escaped the citadel and 41 elderly residents.source
- 1551August 15 – The Siege of Tripoli ends, with the Knights of Malta surrendering Tripoli to the Ottoman Empire.source
- 1551August 30 (1st waxing of Thadingyut 913 ME)– King Bayinnaung of Burma conquers the rebellious Kingdom of Prome (with a capital at Pyay) and kills the rebel Thado Thu, a former servant who had proclaimed himself as King Thado Dhamma Yaza after the 1550 assassination of King Tabinshwehti.source
- 1551September 30 – (1st day of 9th month of Tenbun 21) Tainei-ji incident: A coup in Yamaguchi, by the military establishment of the Ōuchi clan, forces their lord Ōuchi Yoshitaka to commit suicide, and the city is burned.source
- 1552April 8 – Maurice, Elector of Saxony, liberates Augsburg and sets about to capture Charles V, Holy Roman Emperor.source
- 1552May 20 – Learning of the rapid approach of the Elector Maurice, the Emperor Charles V flees from Innsbruck ahead of being captured.source
- 1552June 6 (14th waxing of Waso 914 ME) – Minye Sithu is appointed as the Burmese Viceroy of Martaban by his older brother, Bayinnaung, King of Burma.source
- 1552June 16 – Yuri of Uglich, the only brother of the Russian Tsar Ivan the Terrible, is placed in charge of Russia's domestic affairs as Ivan departs Moscow to lead 150,000 troops in the Russo-Kazan War.source
- 1552July 6 – In Hungary, Drégely Castle is attacked by the Ottoman Empire. Captain György Szondy and c. 140 soldiers in the castle die, after 4 days of fighting against 8,000 Turkish raiders.source
- 1552July 27 – The Ottomans capture the city of Temesvar.source
- 1552September 9 – The Siege of Eger begins as thousands of Ottoman troops, led by General Kara Ahmed Pasha of the Ottoman Empire attack a greatly outnumbered force of Hungarian defenders, captained by István Dobó.source
- 1552October 2 – The Khanate of Kazan falls to troops of Ivan IV of Russia.source
- 1552October 17 – After heavy losses by the Ottoman Empire, the Siege of Eger in Hungary is broken off by the Ottomans.source
- 1552November 15 – Radu Ilie Haidăul becomes the new Prince of Wallachia in what is now Romania after defeating Prince Mircea the Shepherd at the battle of Mănești. Prince Mircea retakes the throne seven months later.source
- 1552Miguel de Buría leads the first African rebellion in South America's history. This may be because Buría has more slaves than other regions in Venezuela, of which most join Miguel, and is still being contested between the Europeans and the natives, who also join his side. During this insurrection he takes over the Gold mines de San Felipe de Buría, established within the area with the consent of the Spanish Crown, to pull out the ore that was discovered in the Buria river, a task that heavily depends on slave work.source
- 1552In the Persian Gulf, the Ottoman Empire Red Sea Fleet attacks the Portuguese stronghold of Hormuz, but fails to capture it.source
- 1553January 2 – The siege of Metz in France, started by Charles V, Holy Roman Emperor during the Italian War of 1551–59 on October 19 last is lifted after 75 days. During the city's defence by the Duke of Guise and 6,000 soldiers, Charles V had lost two-thirds of his original force of at least 20,000 men.source
- 1553June 3 – The first of the five Battles of Kawanakajima, the "Battle of the Fuse," commences in Japan between Takeda Shingen of Kai Province and Uesugi Kenshin of Echigo Province. The clash, fought 12 days after Shingen has taken Katsurao Castle, takes place at a shrine of Hachiman (near modern-day Yashiro, Hyōgo prefecture), is part of a major series of conflicts during the Japanese Sengoku period.source
- 1553July 9 – Battle of Sievershausen: Prince-elector Maurice of Saxony defeats the Catholic forces of Margrave Albert of Brandenburg-Kulmbach. Maurice is mortally wounded.source
- 1553September 23 – The Sadians consolidate their power in Morocco, by defeating the last of their enemies.source
- 1553November 16 – A delegation from the English Parliament formally asks the new queen, Mary I, to choose an English husband rather than to marry Spain's Prince Philip, and suggests Edward Courtenay, 1st Earl of Devon. Queen Mary's choice to marry Philip, in the interests of protecting England from an invasion, will ultimately lead to Wyatt's rebellion.source
- 1553November 25 – Second Margrave War: The city of Kulmbach, near Brandenburg in Bavaria in Germany, is sacked and burned to the ground after its margrave, Albert Alcibiades, makes an unsuccessful attempt to bring all of the Duchy of Franconia under his control.source
- 1553November 25 – Italian War of 1551–1559: Cosimo I de' Medici, Duke of the Florentine Republic, signs a secret treaty with Charles V, Holy Roman Emperor to conquer the Republic of Siena to bring it back into the Empire.source
- 1553December 25 – Battle of Tucapel: Mapuche rebels under Lautaro defeat the Spanish conquistadors, and execute Pedro de Valdivia, the first Royal Governor of Chile.source
- 1553Shanghai is fortified for the first time.source
- 1553The addition of a new section of the Outer City fortifications is completed in southern Beijing, bringing the overall size of Beijing to 18 square miles (4662 hectares).source
- 1554January 21 – Edward Courtenay, one of the four plotters of Wyatt's rebellion in England, is arrested and reveals that an attempt will be made to overthrow the English government.source
- 1554January 27 – Wyatt's rebellion begins in England at Maidstone as Sir Thomas Wyatt reads a proclamation that Queen Mary of England’s marriage to King Philip of Spain will "bring upon this realm most miserable servitude, and establish popish religion". Within two days, Wyatt has raised 2,000 soldiers to join his plan to overthrow Queen Mary.source
- 1554January 30 – Henry Grey, Duke of Suffolk, one of the English conspirators in Wyatt's rebellion, leads troops from Leicester to Coventry, but the group finds that the gates of the city are closed because the rebellion has been exposed.source
- 1554February 9 – Thomas Wyatt surrenders to government forces in London.source
- 1554March 18 – Princess Elizabeth is imprisoned in the Tower of London on charges of working with the organizers of Wyatt's rebellion for the overthrow of Queen Mary of England.source
- 1554May 9 – Elizabeth is released from the Tower of London, although she continues to be confined at home after she is cleared of suspicion of conspiracy to overthrow the government.source
- 1554June 11 – Italian General Piero Strozzi successfully defends an attack on the Republic of Siena by French troops, led by Cosimo de' Medici at the battle of Pontedera, but suffers a tremendous loss of his own troops in the process.source
- 1554August 2 – Battle of Marciano: Senese–French forces are defeated by the Florentine–Imperial army.source
- 1554August 12 – Battle of Renty: French forces led by François, Duke of Guise turn back an invasion of Picardy, by Charles V.source
- 1554September 13 (Shawwal 15, 961 AH) – At the Battle of Tadla in Morocco, Mohammed ash-Sheikh, ruler of the Saadi dynasty enters the city of Fez and becomes the undisputed sultan. Ali Abu Hassun, last ruler of the Wattasid dynasty, flees.source
- 1554October 8 – In Peru, an 11-month long rebellion by Francisco Hernández Girón is ended at the Battle of Pucará with the rebels defeated by the Viceroy of Peru near Cuzco.source
- 1554October 21 – The Plassenburg castle in Bavaria, residence of the ruling House of Hohenzollern in the Principality of Ansbach, is destroyed during the Second Margrave War.source
- 1554Saadi conquers the Kingdom of Fez.source
- 1554Exact center year of Counter Reformation.source
- 1554Rao Surjan Singh becomes ruler of Bundi.source
- 1555January 22 – The Kingdom of Ava in Upper Burma falls.source
- 1555April 17 – After 18 months of siege, the Republic of Siena surrenders to the Florentine–Imperial army.source
- 1555June 22 – Adil Shah Suri becomes the Sultan of the Sur Empire at Delhi in India after Sikandar Shah Suri is forced to flee from the Mughal Empire forces.source
- 1555October 16 – (1st day of 10th month Tenbun 24) – At the Battle of Miyajima Island, Mori Motonari defeats Sue Harukata.source
- 1555Russia breaks a 60-year-old truce with Sweden by attacking Finland.source
- 1556February 5 – Truce of Vaucelles: Fighting temporarily ends between France and Spain.source
- 1556April 3 – In Qazvin, the Shah of Iran Tahmasp I, becomes enraged with the sexual orientation of his son Ismail II, and sends Ismail to Afghanistan to serve as the Iranian governor of Herat province.source
- 1556April 24 – Pál Márkházy surrenders the Hungarian fortress at Ajnácskő (now Hajnáčka in Slovakia) to the Ottoman Empire. Márkházy, accused of treachery, is stripped of his estates and title by the King of Hungary, and forced to flee to the Principality of Transylvania.source
- 1556May 28 (20th day of 4th month of Kōji 2) – In Japan, the Battle of Nagara-gawa takes place along the Nagara River in Mino Province near what is now the Gifu Prefecture. Saitō Yoshitatsu, with 17,500 troops, overwhelms and kills his father, Saitō Dōsan, who had attempted to avenge the Saitō family honor with less than 3,000 people.source
- 1556July 17 – Kostajnica Fortress in what is now Croatia falls to the Ottoman Empire and remains under Turkish control for the next 132 years.source
- 1556September 1 – After Pope Paul IV attempts to get King Henry II of France to join him in an invasion of Spanish-controlled Naples, Spain's Duke of Alba invades the Papal States in Italy.source
- 1556October 7 – The Battle of Delhi is fought in India, at Tughlaqabad) near Delhi between forces of the Sur Empire (ruled by Muhammad Adil Shah) and the Mughal Empire (ruled by Akbar the Great). General Hemchandra Vikramaditya (Hemu) of the Suris overwhelms the forces commanded by the Mughal Governor of Delhi, Tardi Beg Khan within one day.source
- 1556November 5 – Second Battle of Panipat: Fifty miles north of Delhi, a Mughal army defeats the forces of Hemu and recaptures Delhi for the Mughal Empire, guaranteeing Akbar's rule.source
- 1556December 7 – The Mughal Emperor Akbar personally travels with Bairam Khan to lead an invasion force to defeat the Sultan of the Sur Empire, Sikandar Shah Suri.source
- 1557January 6 – Italian War of 1551–1559: Gaspard II de Coligny, the French governor of Picardy (in northern France), launches surprise attacks on Douai and Lens in the Spanish Netherlands and captures both cities for France.source
- 1557January 28 – Bayinnaung, King of Burma and head of the Toungoo dynasty, conquers two the Shan States, Möng Mit and Hsipaw in what is now northern Myanmar. The event is later commemorated with an inscription on the Shwezigon Pagoda Bell.source
- 1557March 11 – The Burmese conquest of the Shan States continues as the capital of the Mongkawng state, Mong Kawng, falls to the Toungoo dynasty invaders, five days after the March 6 surrender of the town of Mong Yang. The event is later commemorated on the Shwezigon Pagoda Bell.source
- 1557March – The Takeda clan besiege Katsurayama Castle in eastern Japan. The siege ends with the last stand of the castle garrison, and the complete destruction of Katsurayama, allowing the Takeda to further expand in Shinano Province.source
- 1557April 25 – English aristocrat Thomas Stafford attempts a rebellion against Queen Mary I, landing at Scarborough, North Yorkshire with two ships and 32 followers after crossing the English Channel from Dieppe in France. Upon landing, he captures Scarborough Castle and proclaims himself "Protector of the Realm".source
- 1557April 28 – Henry Neville, 5th Earl of Westmorland, arrives in Scarborough and ends the Stafford rebellion, arresting Stafford and the small rebel force.source
- 1557April 30 – Arauco War – Battle of Mataquito: Spanish forces of Governor Francisco de Villagra launch a dawn surprise attack against the Mapuche (headed by their toqui Lautaro), in present-day Chile.source
- 1557May 28 – English rebel Thomas Stafford and 32 of his followers are beheaded at the Tower of London after being convicted of treason.source
- 1557June 7 – Mary I of England joins her husband Philip II of Spain, in his war against France.source
- 1557July 25 – In India, Sikandar Shah Suri, Sultan of the Sur Empire in Punjab, surrenders the fortress at Mau in the Nurpur kingdom (now in Uttar Pradesh) after a six month siege by the Mughal Empire. Mughal General Bairam Khan allows Sikandar to live in exile in Bihar, while Bakht Mal, Raja of Nurpur is imprisoned at Lahore and later beheaded.source
- 1557August 27 – Battle of St. Quentin: French forces under Marshal Anne de Montmorency, 1st Duke of Montmorency are decisively defeated by the Spanish and English under Emmanuel Philibert, Duke of Savoy, after a 17-day battle. Montmorency himself is captured, but Philip II refuses to press his advantage, and withdraws to the Netherlands.source
- 1557October 23 – Mohammed al-Shaykh, Sultan of Morocco since 1549, is assassinated by Ottoman soldiers who had infiltrated the Moroccan army. The assassination comes on orders of the Ottoman sultan after Mohammed makes plans for an alliance with Spain against the Ottoman Empire. Mohammed is succeeded by his son, Abdallah al-Ghalib.source
- 1557December 30 – Italian War of 1551–1559: King Henri II of France, through his ambassador Jean Cavenac de la Vigne sends a letter to Suleiman the Magnificent, Sultan of the Ottoman Empire for the dispatch of 150 Ottoman Navy ships to protect the French coast.source
- 1557Özdemir Pasha conquers the Red Sea port of Massawa for the Ottoman Empire.source
- 1558January 7 – French troops, led by François, Duke of Guise, take Calais, the last continental possession of the Kingdom of England, in the Siege of Calais.source
- 1558January 22 – The Livonian War begins.source
- 1558February 4 – (16th day of 1st month of Eiroku 1) Takeda Shingen becomes the shugo (military governor) of Shinano Province after his successful military campaign there.source
- 1558February 5 – Arauco War: Pedro de Avendaño, with sixty men, captures Caupolicán (the Mapuche Gran Toqui), who is leading their first revolt against the Spanish Empire (near Antihuala), encamped with a small band of followers.source
- 1558April 17 – The siege of Thionville in the Duchy of Luxembourg, is started by the French Army, led by François, Duke of Guise.source
- 1558June 13 – An armada of ships from the Ottoman Empire, dispatched by Sultan Suleiman the Magnificent at the request of King Henry II of France, sails into the Bay of Naples at Italy and attacks the city of Sorrento.source
- 1558June 23 – France is successful in the siege of Thionville in the Duchy of Luxembourg and recovers the fortress from the Spanish Empire after an operation that began on April 17 and lasted more than two months.source
- 1558July 9 – The Ottoman Empire, with 15,000 troops and 150 warships, besieges the Spanish garrison at Ciutadella de Menorca at Spain's Balearic Islands. When the town falls on July 17, the 3,099 surviving inhabitants are sold into slavery.source
- 1558July 13 – Battle of Gravelines: Near the border between the Kingdom of France and the Spanish Netherlands, Spanish forces led by Lamoral, Count of Egmont, and assisted by the English Navy, inflict a major defeat on the French forces of Marshal Paul de Thermes.source
- 1558July 18 – The city of Tartu, capital of the Bishopric of Dorpat (in modern-day Estonia) surrenders to Russia.source
- 1559March 23 – Emperor Gelawdewos of Ethiopia, defending his lands against the invasion of Nur ibn Mujahid, Sultan of Harar, is killed in battle. His brother, Menas, succeeds him as king.source
- 1559October 24 – Backed by Ottoman Empire troops, the army of Wallachia defeats the boyars at the battle of Boiani. The Ottoman central government at Constantinople confirms Petru as the rightful ruler of the principality within the Empire.source
- 1559November 5 – In Scotland, Crichton Castle, home of the powerful Earl of Bothwell, is besieged and captured in an attack by the Earl of Arran.source
- 1559November 6 – The Ottoman Empire ends its attempt to wrest control of the island of Bahrain from Portuguese control, after a siege of Manama Castle that began on July 2.source
- 1560January 7 – In the Kingdom of Scotland, French troops commanded by Henri Cleutin and Captain Corbeyran de Cardaillac Sarlabous sail across the Firth of Forth from Leith, which they are occupying, and fight with the Lords of the Congregation at Pettycur Bay near Kinghorn.source
- 1560March 17 – Leaders of the Amboise conspiracy, including Godefroy de Barry, seigneur de La Renaudie, make an unsuccessful attempt to storm the château of Amboise, where the young French king and queen are residing. La Renaudie is subsequently caught and executed, along with over 1,000 of his followers.source
- 1560May 11 – In the Battle of Djerba, the Ottoman fleet, commanded by Piali Pasha, overwhelms a large joint European (mainly Spanish) fleet, sinking about half its ships.source
- 1560June 12 (19th day of 5th month of Eiroku 3) – In Japan, Oda Nobunaga defeats Imagawa Yoshimoto in the Battle of Okehazama.source
- 1560August 2 – Livonian War – Battle of Ergeme: Russians defeat the Livonian Brothers of the Sword, precipitating the dissolution of the order.source
- 1560September 18 – After Robert Sempill, 3rd Lord Sempill, a Scottish Catholic, continues to resist the Scottish Reformation, the Duke of Châtellerault and the Earl of Arran commence a siege of Castle Semple at Lochwinnoch. They begin firing artillery at the castle on September 23 and destroys the gatehouse.source
- 1560October 19 – The siege of Castle Semple ends after 31 days when the defenders wave the white flag of surrender.source
- 1560The Mongols invade and occupy Qinghai.source
- 1561January 31 – Mughal Empire General Bairam Khan is assassinated by an Afghan warrior, Mubarak Khan Lohani, while traveling through Gujarat in India.source
- 1561March 23 – Lope de Aguirre, a Basque Spanish conquistador, begins a rebellion against the Spanish Crown in an attempt to take over most of Spanish South America.source
- 1561March 29 – In India, the Mughal Empire Army, led by General Adham Khan defeats the Sultanate of Malwa in a battle at Sarangpur, forcing the Sultan Baz Bahadur to flee.source
- 1561April 14 – The citizens of Nuremberg see what appears to be an aerial battle, followed by the appearance of a large black triangular object and a large crash (with smoke) outside the city. A news notice (an early form of newspaper) is printed on April 14, describing the event.source
- 1561July – Arauco War: The hated encomendero Pedro de Avendaño and two other Spaniards are killed, triggering the Second Great Rebellion of the Mapuche.source
- 1561August 19 – Mary, Queen of Scots, is denied passage through England after returning from France. She arrives at Leith, Scotland later the same day.source
- 1561October 10 – The Siege of Moji in Japan ends with the defenders retaining their position.source
- 1561October 18 – Fourth Battle of Kawanakajima: Takeda Shingen defeats Uesugi Kenshin, in the climax of their ongoing conflicts.source
- 1562January 6 – Shane O'Neill of Tír Eoghain pleads his cause at the Palace of Whitehall in London, before Queen Elizabeth I of England, who recognises his status. He returns to Ireland on May 26, and resumes his rebellious activities by November.source
- 1562February 18 – The siege of the Portuguese fort of Mazagan begins in Morocco as the Sultanate tries to take back control of the area from the Portuguese occupiers.source
- 1562March 1 – Over 80 Huguenots are massacred by the ultra-Catholic François, Duke of Guise in Wassy-sur-Blaise, triggering the First War of Religion in France.source
- 1562March 4 – Prince Abu Abdallah Mohammed II Saadi, heir to the throne of the Sultanate of Morocco, arrives at Mazagan with 100,000 troops.source
- 1562March 24 – Portuguese Navy Captain Álvaro de Carvalho reaches Mazagan in Morocco with a relief force that includes 600 well-equipped troops. Another force of 1,565 volunteers arrives on March 26 from Lisbon.source
- 1562April 2 – Civil war breaks out in the Kingdom of France as Louis I, Prince of Condé, leader of the Protestant Huguenots, declares war against the French Catholic rulers, in retaliation for the March 1 massacre of Vassy. Condé and Gaspard de Coligny seize control of Orléans, and other uprisings follow throughout France.source
- 1562May 5 – Prince Abdullah of Morocco withdraws his troops after seeing no way to overcome Portuguese defenses at Marzagan.source
- 1562May 28 – The Siege of Rouen as Claude, Duke of Aumale, leads 3,000 French government troops against the Huguenot fortress at Rouen. The siege lasts for five months. He orders a retreat in June but returns on 29 July with a larger force and heavier artillery.source
- 1562June 17 Full moon of Waso 924 ME– King King Bayinnaung of Burma establishes an army garrison at Dawei in preparation for an attack against the Siamese Kingdom of Ayutthaya.source
- 1562August 24 – In the French city of Bar-sur-Seine, at least 300 Huguenots are massacred by Catholic soldiers after their success in reconquering the citadel there. The killing occurs nine days after the burning alive of 94 Huguenots at Lauzerte.source
- 1562October 4 – English forces under Ambrose Dudley, 3rd Earl of Warwick, land at Le Havre to aid the Huguenots against the French Crown.source
- 1562October 26 – Rouen is captured by Royalist forces under King Antoine of Navarre, who is mortally wounded.source
- 1562November 5 – Battle of Corrichie in Scotland: The rebellion of George Gordon, Earl of Huntly is crushed by James Stewart, 1st Earl of Moray.source
- 1562December 19 – Battle of Dreux: Huguenot and Catholic forces fight a bloody battle, narrowly won by the Catholic side. The official leaders of both armies are captured in the battle.source
- 1562Mughal Emperor Akbar conquers Malwa, and its last Sultan, Baz Bahadur, flees.source
- 1562The Portuguese army is defeated at the Battle of Mulleriyawa, Sri Lanka, at the hand of the Sitawaka army commanded by Prince Tikiri Bandara (King Rajasinghe), leaving 1600 dead. This is considered the worst defeat the Portuguese have suffered up to this time.source
- 1563February 18 – François, Duke of Guise, is assassinated while besieging Orléans by Jean de Poltrot.source
- 1563May 5 (3rd day of 4th month, Eiroku 6) – The Battle of Yudokoru takes place in Japan at the Inaba Province (now the eastern Tottori Prefecture), as Takanobu Takeda defeats the shogun Toyokazu Yamana.source
- 1563May 30 – At Bornholm, the Danish fleet fires on the Swedish navy, leading to a Danish defeat and precipitating the Northern Seven Years' War.source
- 1563July 28 – The English surrender Le Havre to the French after a siege.source
- 1563August 13 – Northern Seven Years' War: Denmark–Norway and the Free City of Lübeck declare war against the Kingdom of Sweden.source
- 1563September 4 – Northern Seven Years' War: King Frederick II of Denmark, advancing from Halland, takes Old Älvsborg from Sweden.source
- 1563November 9 – The Army of Sweden, under the command of King Eric XIV, suffers a severe defeat in the Battle of Mared against the Army of Denmark, commanded by King Frederik II. In the battle, near what is now the city of Oskarström in Sweden, the Swedes suffer at least 2,500 casualties. The Swedish Army is able to retreat and rebuild, but the Danes plunder the village of Övraby, which is never rebuilt.source
- 1564January 26 – Livonian War – Battle of Ula: A Lithuanian surprise attack results in a decisive defeat of the numerically superior Russian forces.source
- 1564February 7 (11th waning of Tabodwe 925 ME) – Burmese–Siamese War: Invaders from Burma overcome the seaside defenses of the Siamese capital at Ayutthava, capturing the batteries of cannons and a set of ships sent by Portugal to help defend the kingdom.source
- 1564February 18 (8th waxing of Tabaung 925 ME) – The Burmese–Siamese War ends with the surrender of King Maha Chakkraphat of Ayutthaya (now Thailand) to King Bayinnaung of Burma). Chhakkraphat is allowed to go into exile and his son Mahinthrathirat is installed by Bayinnaung as the vassal king of Ayutthaya.source
- 1564February 20 – A group of four men assassinate the Spanish Viceroy of Peru, Diego López de Zúñiga, 4th Count of Nieva. López is succeeded temporarily by Hernando de Saavedra.source
- 1564March 25 – Battle of Angol in Chile: Spanish Conquistador Lorenzo Bernal del Mercado defeats and kills the toqui Illangulién.source
- 1564July 2 In India, the Mughal Emperor Akbar departs from the capital, Agrasource
- 1564August 6 – In India Akbar, ruler of the Mughal Empire, defeats the rebellious governor of Malwa, Abdullah Khan Uzbeg. The defeat comes the day after the Imperial Army's arrival at Indore, now in the Indian state of Madhya Pradesh.source
- 1564August 14 – Sweden's Army fights a second naval battle at Öland against Denmark and captures three Danish Navy ships (Böse Lejonet, Morian, and David) and 600 men.source
- 1564August 28 – King Eric XIV of Sweden, who has been commanding the Swedish Army himself since the start of the Northern Seven Years' War, turns over the responsibility to Nils Boije, who captures Varberg from Denmark.source
- 1564September 4 – The Ronneby Bloodbath takes place in Ronneby, Denmark (now in Sweden).source
- 1564September 10 – Battle of Kawanakajima in Japan: Takeda Shingen fights the forces of Uesugi Kenshin for the final time, to a draw.source
- 1564October 23 – King Bayinnaung of Burma leads 64,000 men, 3,600 horses and 330 elephants on an invasion of the Lan Na kingdomsource
- 1564November 25 – When four divisions of the Burmese Army arrive at Lamphun, 12.5 mi from Chiang Mai, Chiang Mai's defenses flee the city. Bayinnaung spares the life of King Mekuti of Lan Na, and then spends next four months administering the annexed territory.source
- 1565January 3 – In the Tsardom of Russia, Ivan the Terrible originates the oprichnina (repression of the boyars (aristocrats)).source
- 1565January 23 – Battle of Talikota: The Vijayanagara Empire, the last Hindu kingdom in South India, is greatly weakened by the Deccan sultanates.source
- 1565February 13 – Spanish Conquistador Miguel López de Legazpi lands with his troops on the shores of Cebu Island in the Philippines.source
- 1565March 16 – Spanish Conquistador López de Legazpi makes a blood compact (sandugan) with Datu Sikatuna in the island of Bohol, Philippines.source
- 1565May 18 – Ottoman troops land on the island of Malta, beginning the Great Siege of Malta.source
- 1565June 17 – (19th day of 5th month, Eiroku 8); In Japan, Ashikaga Yoshiteru, the Ashikaga shogun, commits ritual suicide after Matsunaga Hisahide invades Kyoto.source
- 1565August 26 – The Chaseabout Raid begins in Scotland as a rebellion against Mary, Queen of Scots by her half-brother, by James Stewart, 1st Earl of Moray, following her July 29 marriage to Lord Darnley.source
- 1565August 31 – Chaseabout Raid: Moray and at least 1,000 of his rebels arrive in Edinburgh for a confrontation with the Scottish crown. After cannon fire from Edinburgh Castle, the rebels retreat toward England to seek help. The rebellion is ended by the end of September.source
- 1565September 11 – The Knights of Malta lift the Great Siege of Malta after four months.source
- 1565October 18 – Battle of Fukuda Bay: Ships belonging to the Matsura clan of Japan fail to capture a Portuguese trading carrack, in the first recorded naval battle between Japan and a European nation.source
- 1565October 20 – In the Northern Seven Years' War, the Battle of Axtorna is fought in Sweden, near Falkenberg, as Daniel Rantzau of the Army of Denmark and Norway leads 7,400 troops in defeating a counterattack by over 11,000 Swedish troops led by Jacob Henriksson Hästesko.source
- 1565November 25 – The army of Burma, under the command of King Bayinnaung conquers Chiang Mai, capital of the Siamese Kingdom of Lan Na, and departs on November 30.source
- 1565December 31 – The Burmese Army conquers Vientiane, the main city of the kingdom of Lan Xang (now Laos).source
- 1565December – The Mariovo and Prilep rebellion occurs, the very first recorded rebellion by the Macedonian hajduks or voivode against the Ottoman Empire.source
- 1566February 24 – In one of the first gun assassinations in Japanese (if not world) history, Mimura Iechika, the daimyō (warlord) of the Bitchū Province, is shot dead by two brothers (Endo Matajiro and Yoshijiro), sent by his rival Ukita Naoie.source
- 1566May 13 – Maximilian II, Holy Roman Emperor imposes a Reichsexekution upon John Frederick II, Duke of Saxony. Augustus, Elector of Saxony is directed to carry out the order to begin the siege of the city of Gotha and John Frederick's home at the Grimmenstein Castle.source
- 1566June 10 – In Znojmo (in the modern-day Czech Republic), Wilhelm von Rosenberg, commander of the Army of the Kingdom of Bohemia, begins raising an army to fight an expected invasion by the Ottoman Empire.source
- 1566July 28 – John Sigismund Zápolya, uncrowned claimant to the throne of the King of Hungary, leads an invasion of Upper Hungary on the orders of Ottoman Sultan Suleiman.source
- 1566August 6 – The siege of Szigetvár is begun by Suleiman the Magnificent, Sultan of the Ottoman Empire. This is the Ottoman Empire at its greatest extent.source
- 1566October 19 – Gastón de Peralta, 3rd Marquess of Falces becomes the Viceroy of New Spain, replacing Francisco Ceinos. Peralta is removed from office by King Philip II after charges are made that Peralta is planning a rebellion against the crown.source
- 1567January 20 – Battle of Rio de Janeiro: Portuguese forces under the command of Estácio de Sá definitively drive the French out of Rio de Janeiro.source
- 1567January – A Spanish force under the command of Captain Juan Pardo establishes Fort San Juan, in the Native American settlement of Joara. The fort is the first European settlement in modern-day North Carolina.source
- 1567March 13 – Battle of Oosterweel: A Spanish mercenary army surprises and kills a band of rebels near Antwerp in the Habsburg Netherlands, beginning the Eighty Years' War.source
- 1567April 9 – In India, the Battle of Thanesar is fought in what becomes the state of Haryana. The Mughal Emperor Akbar, with 300 men, wins a victory over more than 7,000 warriors of the Sanyasi Hindu sect. Akbar's army has two cannons, 400 rifles and 75 elephants.source
- 1567June 15 – Mary, Queen of Scots, is defeated by Scottish nobles at the Battle of Carberry Hill and imprisoned in Lochleven Castle.source
- 1567September 27 – After the 2-week Siege of Inabayama Castle, the Oda clan capture Gifu Castle from the Saitō clan in Japan.source
- 1567September 29 – The Second War of Religion begins in France, when Louis I, Prince of Condé and Gaspard de Coligny fail in an attempt to capture King Charles IX and his mother at Meaux. The Huguenots do capture several cities (including Orléans), and march on Paris.source
- 1567November 10 – Battle of Saint-Denis: Anne de Montmorency, 1st Duke of Montmorency, with 16,000 Royalists, falls on Condé's 3,500 Huguenots. The Huguenots surprisingly hold on for some hours before being driven off. Montmorency is mortally wounded.source
- 1568February 16 – Fernando Álvarez de Toledo, 3rd Duke of Alba, governor of the Spanish Netherlands issues an edict condemning to death those who rebel against Spanish authority to combat religious unrest.source
- 1568February 23 – Akbar the Great of the Mughal Empire captures the massive Chittor Fort in northern India from the Kingdom of Mewar after the Siege of Chittorgarh that began on October 23, 1567.source
- 1568February 28 – French Huguenots begin the Siege of Chartres, but fail to take the walled city after 15 days.source
- 1568April 23 – Eighty Years' War: The Battle of Dahlen takes place in the Duchy of Jülich near the modern-day Rheindahlen borough in the German city of Mönchengladbach, North Rhine-Westphalia. Spanish troops, commanded by Sancho d'Avila, overwhelm a larger force of Dutch rebels led by Jean de Montigny, Lord of Villers.source
- 1568May 13 – Marian civil war in Scotland: Battle of Langside – The forces of Mary, Queen of Scots, are defeated by a confederacy of Scottish Protestants under James Stewart, 1st Earl of Moray, regent of Scotland and her half-brother.source
- 1568May 16 – Mary, Queen of Scots, flees across the Solway Firth from Scotland to England but on May 19 is placed in custody in Carlisle Castle on the orders of Queen Elizabeth I, her cousin.source
- 1568May 23 – Battle of Heiligerlee: Troops under Louis of Nassau, brother of William the Silent, defeat a smaller loyalist force under Jean de Ligne, in an attempt to invade the Northern Netherlands. This effectively begins the Eighty Years' War.source
- 1568June 27 – Ottoman pirate Kılıç Ali Pasha, formerly Italian farmer Giovanni Dionigi Galeni, is appointed as the Ottoman Beylerbey of Ottoman Algeria by the Sultan Selim II.source
- 1568July 21 – Battle of Jemmingen: The main Spanish army of the Duke of Alba utterly defeats Louis of Nassau's invading army in the Northeastern Netherlands.source
- 1568August 18 – The Third War of Religion begins in France, after an unsuccessful attempt by the Royalists to capture Louis I, Prince of Condé and Gaspard II de Coligny, the Huguenot leaders.source
- 1568September 24 – Battle of San Juan de Ulúa (Anglo-Spanish War): In the Gulf of Mexico, a Spanish fleet forces English privateers under John Hawkins to end their campaign.source
- 1568September 29 – The Swedish king Eric XIV is deposed by his half-brothers John and Charles. John proclaims himself king John III the next day.source
- 1568October 5 – William the Silent invades the southeastern Netherlands.source
- 1568October 18 — Ashikaga Yoshiaki is installed as Shōgun, beginning the Azuchi–Momoyama period in Japan.source
- 1568October 20 – Battle of Jodoigne: Spanish forces under the Duke of Alba destroy William the Silent's rearguard and William abandons his offensive.source
- 1568November 12 – Dutch rebels commanded by William the Silent defeat Spanish Habsburg troops led by Sancho d'Avila in the battle of Le Quesnoy in northern France.source
- 1568November 27 – Burmese–Siamese War: Dispatched by King Bayinnaung, 55,000 Burmese troops arrive at Phitsanulok (in modern-day Thailand) and drive back the attack by armies from the Ayutthaya Kingdom (Thailand) and Lan Xang (Laos), then prepare to invade Ayutthaya to put down the rebellion by Ayutthayan King Maha Chakkraphatsource
- 1568December 24 – The Morisco Revolt against King Philip II of Spain begins as Aben Humeya (formerly Fernando de Válor) is proclaimed as King of the Granadan rebels.source
- 1568The Russo-Turkish War begins in Astrakhan.source
- 1569March 13 – Battle of Jarnac: Royalist troops under Marshal Gaspard de Tavannes surprise and defeat the Huguenots under Louis I, Prince of Condé, who is captured and murdered. A substantial proportion of the Huguenot army manages to escape, under Gaspard II de Coligny.source
- 1569May 8 – King Bayinnaung of Burma puts down the revolt by Setthathirath of Lan Xang (modern Laos), and ending Lan Xang's attempt to rescue Thailand's Ayutthaya Kingdom from conquest.source
- 1569June 10 – German Protestant troops reinforce Coligny, near Limoges.source
- 1569July 24 – Huguenot forces under Gaspard II de Coligny and 15-year-old Prince Henry of Navarre begin the siege of Poitiers, a Roman Catholic stronghold. The siege fails and the Huguenots depart on September 7.source
- 1569August 2 – Burma invades Siam and captures Ayutthaya. Siam becomes a vassal of Burma.source
- 1569August 24 – Battle of Orthez: Huguenot forces under Gabriel de Lorges, Count of Montgomery defeat Royalist forces under General Terride, in French Navarre. Catholics surrender under the condition that their lives will be spared. Huguenots agree, but then massacre the Catholics anyway.source
- 1569September 7 – A Royalist army under the Duc d'Anjou and Marshal Tavannes forces Coligny to abandon the siege of Poitiers.source
- 1569September 29 – Maha Thammarachathirat is installed by the Burmese Army as the vassal king of Ayutthaya.source
- 1569October 3 – Battle of Moncontour: The Royalist forces of Gaspard de Saulx Tavannes and the Duc d'Anjou defeat Gaspard II de Coligny's Huguenots, killing 8,000 and taking 3,000 prisoner.source
- 1569November 11 — Danish General Daniel Rantzau arrives at the Swedish-held Varberg castle at Halland and orders his artillery to shell the castle with cannon fire. The Swedish defenders fire back with their own artillery and Rantzau's head is taken off by a cannonball on the first day.source
- 1569November 14 — The siege of Varberg Castle by Denmark ends after three days of shelling the Swedish defenders.source
- 1569December 2 — The Catholic army of the Duc d'Anjou inflicts another defeat on the Huguenots of Coligny, successfully besieging Saint-Jean-d'Angély.source
- 1569December 6 — The Kanbara castle, held by the Hōjō clan in what becomes the Shizuoka Prefecture of Japan falls after a siege by Takeda Katsuyori of the Takeda clan. Hōjō Ujinobu, who had 1,000 men defending, commits suicide after the defeat.source
- 1569December 13 — An English counterattack against the Northern rebels begins as Thomas Radclyffe, 3rd Earl of Sussex, marches from York with 10,000 men against the rebels' 6,000. The rebels disperse and flee northward back to Scotland, ending the Rising of the North.source
- 15691569 Plot: The first of three conspiracies with the intent to depose John III of Sweden and reinstate the imprisoned Eric XIV on the Swedish throne is exposed in Sweden.source
- 1570January 8 – Ivan the Terrible begins the Massacre of Novgorod.source
- 1570January 23 – The assassination of Scottish regent James Stewart, 1st Earl of Moray, by James Hamilton, the first known shooting of a national leader, throws Scotland into civil war. Having loaded a carbine rifle and carried it into the Linlithgow home of his uncle, the Archbishop of St Andrews, Hamilton stands at an upstairs window overlooking the street where Moray will ride by on horseback as part of cavalcade. Once Moray comes into range, Hamilton fires and fatally wounds the regent for King James VI.source
- 1570March 28 – The ambassador of the Ottoman Sultan Selim II goes before the governing Council of the Venetian Republic and requests that Venice surrender the island of Cyprus. The Council rejects the demand and prepares to go to war with the Ottoman Empire.source
- 1570May 24 – Battle of Manila: The Spanish, led by Martín de Goiti, defeat the forces of Rajah Sulayman.source
- 1570July 3 – The Ottoman conquest of Cyprus begins as more than 350 Ottoman ships and over 60,000 troops land near Larnaca and then march toward the Cypriot capital, Nicosia.source
- 1570July 22 – The siege of Nicosia by the Ottoman Empire begins in Cyprus and lasts for seven weeks.source
- 1570July 30 (28th day of 6th month of Genki 1) – Battle of Anegawa: The allied forces of Oda Nobunaga and Tokugawa Ieyasu defeat the combined forces of the Azai and Asakura clans.source
- 1570September 9 – Nicosia falls to the Turks under the command of General Lala Mustafa Pasha. After the Ottomans breach the walls, the Venetian defenders are massacred and the women and boys are sold into slavery.source
- 1570September 25 (26th day of 8th month of Genki 1) – The 10-year-long Ishiyama Hongan-ji War begins in Japan as Oda Nobunaga stages simultaneous attacks on two fortresses (Ishiyama Hongan-ji and Nagashima) of the Ikkō-ikki faction near Osaka.source
- 1571February 4 – The Spanish Jesuit missionaries of the Ajacán Mission, established on the Virginia Peninsula of North America in 1570, are massacred by local Native Americans.source
- 1571April 12 – The Ridolfi plot to assassinate Queen Elizabeth I of England is foiled by the capture of Ridolfi's messenger, Charles Baillie.source
- 1571April 21 – In China, General Altan Khan is granted authority to rule the western provinces by the Ming dynasty Emperor Longqing in return for his payment of a tribute.source
- 1571June 3 – Following the Battle of Bangkusay Channel, the conquest of the Kingdom of Maynila is complete; Spanish Conquistador Miguel López de Legazpi makes Manila a city, and the capital of the Philippines.source
- 1571June 24 – On the island of Luzon in the Philippines, Miguel López de Legazpi of Spain establishes a Spanish fortress at Manila Bay and, after making a peace pact with the Crown Prince of Luzon, Rajah Sulayman declares Manila to be the administrative capital of the Spanish East Indies.source
- 1571July 14 – In what is now the state of Kerala in India, the Siege of Chaliyam begins as the Zamorin of Kozhikode, Mana Vikrama, sends troops to starve out the Portuguese Empire's Chale fortress. The Portuguese defender, Dom Jorge de Castro, is allowed to surrender the fort in November and the Portuguese are allowed to march out of the fort. De Castro is executed by the Portuguese Governor-General after returning to Portuguese controlled Goa.source
- 1571August 1 – The Ottoman conquest of Cyprus is concluded, by the surrender of Famagusta. Cyprus is established as an eyalet of the Ottoman Empire, and the first Turkish colony moves into the island.source
- 1571September 5 – John Erskine, Earl of Mar is selected by the Scottish royal family to be the new Regent of Scotland to rule on behalf of the 5-year-old King James VI. The Earl of Mar replaces Matthew Stewart, 4th Earl of Lennox, the King's grandfather, who was assassinated the day before by supporters of his daughter-in-law the imprisoned Mary, Queen of Scots.source
- 1571September 30 (12th day of 9th month of Genki) – In Japan, the Siege of Mount Hiei is carried out by Oda Nobunaga at Ōmi Province (now the Shiga Prefecture). After Nobunaga's 30,000 troops overwhelm the monks of the 4,000 warriors of the Sōhei, Nobunaga orders the massacre of more than 1,500 survivors.source
- 1571October 7 – Battle of Lepanto: Spanish, Venetian, and Papal naval forces, under Don John of Austria, defeat the Ottoman fleet of Müezzinzade Ali Pasha.source
- 1572January 16 – Thomas Howard, 4th Duke of Norfolk, is tried for treason, for his part in the Ridolfi plot to restore Catholicism in England. He is executed on June 2.source
- 1572April 1 – Capture of Brielle: The Sea Beggars, Netherlandish Calvinist rebels, capture the port city of Brielle. This leads to a wave of uprisings in Holland and Zeeland against Spanish Habsburg rule, leaving most of those provinces (with the exception of Amsterdam) under rebel control.source
- 1572June 14 (4th day of 5th month, Genki 3) – At the Battle of Kizaki, Shimazu Yoshihiro leads an army of just 300 men to defeat the 3,000 strong Ito clan of Itō Yoshisuke.source
- 1572June 25 – The Sea Beggars capture the city of Gorkum; several Roman Catholic priests are imprisoned.source
- 1572July 29–August 2 – Battle of Molodi: A large Crimean–Ottoman army which invaded Russia is routed.source
- 1572August 24 – St. Bartholomew's Day massacre: Catholics in Paris murder thousands of Protestants, including Gaspard de Coligny and Petrus Ramus, at the order of King Charles IX, with Catherine de Medici's connivance. Henry of Navarre and the Prince of Condé barely escape the same fate. This brings about the Fourth War of Religion in France.source
- 1572September 19 – The Siege of Mons, which started on June 23, ends with the recapture of Valenciennes by the Spanish Army from the Dutch Huguenots in what is now Belgium. Louis of Nassau, the Dutch rebel commander, surrenders to the Duke of Alba.source
- 1572October 2 – Spanish Fury at Mechelen: The mostly Catholic population of the Netherlands city of Mechelen (now in Belgium) surrenders to the Spanish Army and signifies its intention to offer no resistance, singing Catholic psalms of penitence to welcome the Catholic Spaniards. Nevertheless, the Duke of Alba authorizes his troops to conduct three days of slaughter, rape and pillaging.source
- 1572October 20 – Eighty Years' War – Relief of Goes: Soldiers of the Spanish Tercios wade across the estuary of the Scheldt, to relieve the siege of Goes in the Spanish Netherlands.source
- 1572November 9 – Siege of Sancerre: Catholic forces of the king lay siege to Sancerre, a Huguenot stronghold in central France. The fortified city holds out for nearly eight months, without bombard artillery. This is one of the last times that slings are used in European warfare.source
- 1572November 14 – Residents of the Belgian city of Zutphen are massacred by the Spanish Army.source
- 1572November 22 – All but 60 of the 3,000 residents are massacred by the Spanish Army in the Belgian city of Naarden.source
- 1572December 11 – The Siege of Haarlem is begun by the Duke of Alva, Spanish Army commander in the Netherlands, and lasts until July 13, 1573.source
- 1573January 28 – The Croatian–Slovene Peasant Revolt, started by Matija Gubec, breaks out against the Croatian nobility, but is suppressed after 18 days.source
- 1573February 6 – In the battle of Kerestinec, General Gašpar Alapić defeats the rebel troops led by Gubec.source
- 1573February 9 – Croatian troops, led by General Alapic, defeat the peasant rebellion in the Battle of Stubica, then begin a violent campaign of vengeance against the conquered rebels. Rebellion leaders Matija Gubec and Ivan Pasanec are taken as prisoners of war for a trial for treason at Zagreb.source
- 1573February 11 – Fourth War of Religion: France's Marshal Henri de Montmorency, begins the Siege of Sommières in southern France. The Huguenots, French Protestants, hold out for almost two months against Montmorency's Catholic troops.source
- 1573February 16–March – The siege of Noda Castle begins near what is now the city of Shinshiro in Japan, after the leader of the Takeda clan, the warlord Takeda Shingen, is shot by a sniper after offering generous terms of surrender to the Tokugawa clan, led by Tokugawa Ieyasu. By March 10, the Noda Castle surrenders.source
- 1573February 23– In the province of Munster in Ireland, the first Desmond Rebellion, led by James FitzMaurice FitzGerald, cousin of the Earl of Desmond, ends at Kilmallock as FitzGerald makes a humiliating surrender to John Perrot, the provincial leader.source
- 1573March 7 – The Ottoman–Venetian War (1570–1573) is ended by a peace treaty, confirming the transfer of control of Cyprus from the Republic of Venice to the Ottoman Empire, and also confirming Turkish occupation of the more fertile region of Dalmatia.source
- 1573April 9 – The Siege of Sommières ends with the surrender of the Huguenot defenders, who are spared retaliation by General Montmorency, despite the loss of 2,500 royal troops.source
- 1573April 22 – Eighty Years' War: The Battle of Borsele is fought as a fleet of Spanish ships is intercepted by Dutch Calvinist rebels (the Geuzen). While some of the ships are able to complete their mission of supplying the Spanish-governed Netherlands cities of Middelburg and Arnemuiden, most are forced to retreat to Amberes in the Spanish Netherlands, now Antwerp in Belgium.source
- 1573May 26 – Battle of Haarlemmermeer: Geuzen ships, attempting to break the siege of Haarlem, are defeated by a combined Spanish and Amsterdam fleet.source
- 1573June 24 – After Henry, Duke of Anjou learns that he has been elected the King of Poland, he agrees to negotiate an end to the Siege of La Rochelle, which has continued for almost nine months against the Huguenots in the western French city, and reaches an agreement with the Huguenot defender, the Count of Montgomery.source
- 1573July 12 – Siege of Haarlem: Spanish forces under the Duke of Alva capture Haarlem, after a seven-month siege.source
- 1573August 21 – The Duke of Alva begins the siege of Alkmaar in North Holland, before retreating after seven weeks.source
- 1573August 27 – Oda Nobunaga drives the 15th Ashikaga shōgun Ashikaga Yoshiaki out of Kyoto, effectively destroying the Ashikaga shogunate, and historically ending the Muromachi and Sengoku periods. The Azuchi–Momoyama period of Japan begins.source
- 1573September 16 – In Japan, elimination of the Asakura clan is completed by Oda Nobunaga after the siege of Hikida Castle and the siege of Ichijōdani Castle are completed in eight days.source
- 1573September 26 – The Azai clan is eliminated by Oda Nobunaga after the four day siege of Odani Castle in Japan.source
- 1573October 8 – The Spanish abandon the siege of the city of Alkmaar and concede the city to the Geuzen, the Dutch Calvinist rebels.source
- 1573October 11 – The Spanish under John of Austria take Tunis with little resistance.source
- 1573Sarsa Dengel, emperor of Ethiopia, defeats the Oromo in a battle near Lake Zway.source
- 1574January 29 – Off of the coast of the Netherlands, the Battle of the Scheldt is fought between the Spanish Fleet and a combined Dutch and English fleet of ships. The Spanish Navy loses 15 ships and 1,200 men are killed, wounded or captured.source
- 1574February – The fifth War of Religion against the Huguenots begins in France.source
- 1574March 2 – Swedish troops attack Wesenberg Castle in Estonia and lose at least 1,000 men in attempting to capture it from the Russian Army.source
- 1574March 17 – Within the Swedish Army, a fight between Scottish and German mercenaries is fought. By the end of the battle, several hundred Scots are dead, compared to 30 Germans.source
- 1574April 14 – Battle of Mookerheyde: Spanish forces under Sancho de Avila defeat the rebel forces of Louis of Nassau, who is killed.source
- 1574April – The fort of Narnala in the Deccan falls to the Ahmadnagar Sultanate, and with it the Berar sultanate is annexed by Ahmadnagar.source
- 1574July 12 – Selim II, Sultan of the Ottoman Empire, launches the attempt to reclaim Tunis from control of the Holy Roman Empire with more than 250 warships and 100,000 troops, and to restore North Africa to Muslim control.source
- 1574August 24 – The Tunisian port of La Goulette falls to Ottoman troops after six weeks.source
- 1574September 13 – The last Holy Roman Imperial defenders surrender Tunis to the Ottoman General Cığalazade Yusuf Sinan Pasha.source
- 1574September – A plot to assassinate John III of Sweden is discovered, headed by Charles de Mornay and implicating Charles Dancay, Hogenskild Bielke, Gustaf Banér, Pontus De la Gardie, Princess Elizabeth of Sweden, Princess Cecilia of Sweden, and Duke Charles.source
- 1574October 3 – The city of Leiden, besieged by the Spanish, is relieved by a Sea Beggars fleet under Louis Boisot.source
- 1574November 29 – Limahong and Juan de Salcedo quarrel during the Battle of Manila.source
- 1574Prince El-Mirza of Kakheti is defeated in his bid for the throne by his half-brother, Alexander II.source
- 1575March 3 – Battle of Tukaroi: The Mughal Empire decisively defeats the Karrani dynasty of Bengal. The battle took place near the village of Tukaroi in present-day Balasore District of Odisha.source
- 1575April 18 – Bayinnaung, King of Burma, returns to his capital at Pegu from Vientiane after installing Voravongsa I as the Burmese-appointed monarch of the Kingdom of Lan Xang (now Laos).source
- 1575May 12 – King Henry III of France, who had been selected in 1573 by the nobles of Poland and Lithuania to be King of Poland as Henryk Walezy, is stripped of his Polish and Lithuanian titles after failing to return to Kraków by the deadline imposed by the Polish nobility.source
- 1575June 28 – Battle of Nagashino: Oda Nobunaga defeats Takeda Katsuyori in Japan's first modern battle.source
- 1575July 7 – Raid of the Redeswire: Sir John Carmichael defeats Sir John Forster, in the last battle between England and Scotland.source
- 1575September 22 – Ottoman forces led by Ferhad Pasha Sokolović defeat the Austrian Army, led by Herbard VIII von Auersperg, in the Battle of Budačka. Auersperg is decapitated and Ferhad Pasha leaves Croatia with the head as a trophy.source
- 1575October 10 – Battle of Dormans: Catholic forces under Henry I, Duke of Guise defeat the Protestants, capturing Philippe de Mornay among others.source
- 1575November 9 – Ferhad Pasha Sokolović returns to Constantinople in triumph with the head of General Auersperg as a trophy after his September 22 victory at Budecka.source
- 1575Russians occupy Pernau in western Estonia, and the fortress of Weissenstein.source
- 1576February 5 – King Henry of Navarre, captive in France since 1572 and alive only because he converted to Catholicism, escapes to Tours and formally reverts to the Protestant faith.source
- 1576March 11 – The city of Fez, part of the Saadi Sultanate in modern-day Morocco is captured by Ottoman forces led by Abd al-Malik, in an attempt to overthrow the Sultan Muhammed al-Mutawakkil and to make the Sultanate a vassal of the Ottoman Empire.source
- 1576April 14 – Ishiyama Hongan-ji War: In Japan, the Third Battle of Ishiyama begins as Oda Nobunaga sends 10,000 soldiers against the Ashikaga shogunate to capture the Honganji Temple.source
- 1576May 14 – Tahmasp I, the Shah of Safavid Iran for almost 52 years, is accidentally poisoned after being treated by the palace physician, Abu Naser Gilani. Tahmasp's death is followed by a deadly struggle for control of Iran.source
- 1576May 27 – An attempt by the Dutch Republic to end the Siege of Zierikzee and free the city from Spain fails after Spanish forces are tipped off about a surprise attack. Dutch Admiral Lodewijk van Boisot is killed in the battle.source
- 1576June 13 – Dutch forces withdraw to free Zierikzee, and the city is left to defend itself. The defenders then attempt negotiations with the Spanish attackers, commanded by General Cristóbal de Mondragón.source
- 1576June 18 – In the Battle of Haldighati in India, Mughal Imperial forces, led by Man Singh I of Amer, decisively defeat the Mewar Kingdom led by Maharana Pratap.source
- 1576July 12 – The Mughal Empire annexes Bengal after defeating the Bengal Sultanate at the Battle of Rajmahal.source
- 1576July 25 – Rebellious Spanish troops plunder the Flemish city of Aalst and then use it as their base of operations to attack other cities.source
- 1576July 29 – The Siege of Zierikzee in the Netherlands ends with the surrender of the defenders to the Spanish Army.source
- 1576August 23 – On the island of Kyūshū in Japan, near what is now Takaharu, Miyazaki prefecture, Takahara Castle of the Itō clan is captured by 30,000 men led by the warlord Shimazu Yoshihisa, after a siege of four days.source
- 1576September 8 – The States General of the Netherlands is convened by the leaders of the States of Brabant and the County of Hainaut in order to respond to mutineering Spanish troops.source
- 1576September 10 – After a siege that has lasted a year and two days, the Spanish Army abandons its siege of the Dutch city of Woerden.source
- 1576October 20 – Spanish rebels plunder the city of Maastricht in Flanders and kill many of the civilian residents in what is later called the "Spaanse Furie" or Fury of Spain.source
- 1576November 4 – Eighty Years' War – Sack of Antwerp: In the Low Countries, mutinous Spanish soldiers sack Antwerp; after three days the city is nearly destroyed.source
- 1576November 8 – Pacification of Ghent: The States General of the Netherlands meet and unite to oppose pillaging Spanish mutineers.source
- 1576November 9 – Shah Ismail II of Iran begins the execution of all persons whom he believes are a threat to his rule, starting with his half-brothers Suleiman Mirza, Governor of Shiraz, and Mustafa Mirza. Over the next seven months, Ismail arranges the execution of six other half-brothers, Mustafa, Junayd, Mahmud, Qoli, Ahmad, and Murza.source
- 1577January 9 – The second Union of Brussels is formed, first without the Protestant counties of Holland and Zeeland (which is accepted by King Philip II of Spain), later with the Protestants, which means open rebellion of the whole of the Netherlands.source
- 1577February 12 – The "Perpetual Edict", providing for the removal of Spanish troops from what is now the Netherlands, is signed in the city of Marche-en-Famenne in the Spanish Netherlands (now Belgium) by the Spanish Governor-General, Don Juan de Austria and representatives of the Dutch rebellion. The Perpetual Edict will last only five months, before Don Juan begins new attacks on the rebels.source
- 1577April 17 – Battle of Lubieszów: General Jan Zborowski leads the army of the Polish–Lithuanian Commonwealth in the catastrophic defeat of most of Jan Winkelbruch's 12,000 rebels and mercenaries from the Commonwealth's richest city, Danzig, killing 4,420 of the men and capturing another 5,000 as prisoners. Only 88 of Zborowski's 2,500 troops are killed. The Danzig Rebellion ends at the end of the year.source
- 1577June 12 – The French city of Issoire surrenders and 3,000 of its Protestant Huguenots are massacred by the troops of the French Catholic General Francis, Duke of Anjou, on orders by King Henry III of France. The massacre is carried out 20 months after the October 15, 1575 killing of Catholic residents by Matthieu Merle. Most of Issoire's buildings are torn down, and the royal troops leave an inscription on a pillar, Ici fut Issoire ("Here stood Issoire.")source
- 1577November 13 – In the Battle of Tedorigawa, Uesugi Kenshin's forces decisively defeat the forces of Oda Nobunaga, in what will be Kenshin's last victory before his death the following year.source
- 1577November 19 – With defeat coming close in the siege of Shigisan, Matsunaga Hisahide commits suicide.source
- 1577Supposed massacre of the MacDonald inhabitants of the Scottish island of Eigg, by the Clan MacLeod.source
- 1578January 13 – The Siege of Gvozdansko ends in the Kingdom of Croatia as Ottoman Empire troops led by Ferhad Pasha Sokolović capture the fortress at Gvozdansko.source
- 1578January 31 – Battle of Gembloux: Spanish forces under Don John of Austria and Alexander Farnese defeat the Dutch; Farnese begins to recover control of the French-speaking Southern Netherlands.source
- 1578February 12 – Mohammad Khodabanda, older brother of the late Shah Ismail II, begins his reign as the new Shah of Persia (now Iran) after entering the Persian capital at Qazvin, after removing his sister Pari Khan Khanum, who had exercised regal authority after Ismail's death. His first act as ruler is to have Pari Khan Khanum strangled to death.source
- 1578February 13 – Two days after the Battle of Gembloux, Spanish troops capture the city of Leuven, forcing Willem, Prince of Orange, to flee Brussels and relocate to Antwerp.Geoffrey Parker, The Dutch Revolt (Cornell University Press, 1977) p.186source
- 1578March 20 – The Belgian city of Bruges, controlled by Spain, falls to Dutch rebels.source
- 1578June 30 – After having come into conflict on May 17 with his fellow officer, Thomas Doughty, during their circumnavigation of the world, Francis Drake puts Doughty on trial while the flagship Pelican is docked at what is now Argentina. A jury of sailors convicts Doughty of treason and attempted mutiny. Doughty is beheaded on July 2.source
- 1578July 31 – At the Battle of Rijmenam, fought near Antwerp in what is now Belgium, a combined Dutch and English force under the command of the Count of Boussu and England's John Norreys defeats Spanish troops commanded by Don Juan de Austria.source
- 1578August 4 – Sebastian, King of Portugal is killed in the Battle of Alcácer Quibir in North Africa while fighting the Saadi Sultanate. Sebastian's elderly uncle, Cardinal Henry, is named as the heir to the throne, initiating a succession crisis in Portugal.source
- 1578October 21 – Battle of Wenden: The Russians are defeated by the Swedes, who proceed to take Polotsk.source
- 1578December 9 – After more than five years of combat in southern France, the Protestant Huguenot citadel of Ménerbes negotiates a surrender to its French Catholic attackers.source
- 1578Battle of the Spoiling Dyke at Trumpan on the Scottish Isle of Skye: the Clan MacLeod are victorious over the MacDonalds of Uist in a feud.source
- 1578The Ottoman Empire conquers Abkhazia.source
- 1578The Portuguese assist Lord Ōmura Sumitada, the first Christian Japanese daimyo, in repulsing an assault on Nagasaki by the Ryūzōji clan.source
- 1578Sarsa Dengel, Emperor of Ethiopia, defeats and kills Bahr negus Yeshaq along with his Ottoman allies, finally ending his rebellion.source
- 1579January 6 – The Union of Arras unites the southern Netherlands under the Duke of Parma, governor in the name of king Philip II of Spain.source
- 1579January 23 – The Union of Utrecht unites the northern Netherlands in a confederation called the United Provinces. William the Silent becomes Stadtholder, and the Duc d'Anjou, younger brother of Henry III of France, is invited to become hereditary sovereign.source
- 1579February 28 – The seizure in September by Willem IV van den Bergh, of the Boxmeer Castle in September in the Netherlands is condemned by the other Dutch members of the Union of Utrecht.source
- 1579March 2 – Battle of Borgerhout in Brabant (now Belgium): Spanish troops under the command of the Duke of Parma overwhelm rebels fighting for the Union of Utrecht.source
- 1579March 12 – The Siege of Maastricht, a center of the Dutch resistance to Spanish rule, is started in the Netherlands by Spanish troops under the command of Alexander Farnese, Duke of Parma. The siege will last almost four months before Maastricht falls on July 1.source
- 1579April 10 – In the village of Cuers in France, near Toulon rebel peasants kill 600 nobles and upper-class gentlemen of the Catholic League serving the Count of Carces.source
- 1579May 21 – Battle of Mimaomote: In Japan, Doi Kiyonaga defeats the forces of Kumu Yorinobu.source
- 1579July 1 – Maastricht surrenders to Spanish troops after a surprise attack by the Duke of Parma, who had besieged the city for more than three months.source
- 1579July 17 – James FitzMaurice FitzGerald lands with a small force of Irish, Spanish, and Italian troops at Smerwick, on the Dingle Peninsula in south-western Ireland, and commences the Second Desmond Rebellion against the rule in Ireland of Elizabeth I of England.source
- 1579August 17 – "Yasuke", a man of African origin who has been hired as a manager by the Chancellor of the Realm, Oda Nobunaga, arrives in Japan. Called "The Black Samurai" in dramatizations of his experience, he begins a service of three years to the Chancellor, ending on June 21, 1582.source
- 1579August 30 – Livonian War: In what is now Belarus, the city of Polotsk falls to the forces of Stephen Báthory, Grand Duke of Lithuania and King of Poland.source
- 1579September 10 – (5th waning of Tawthalin 941 ME) In the Kingdom of Mrauk U in what is now Myanmar and Bangladesh, King Min Phalaung becomes the owner of the first of three white elephants, and gives himself the title of Hsinbyushin.source
- 1579October 11 – Sokollu Mehmed Pasha, Grand Vizier of the Ottoman Empire for more than 14 years, is assassinated in Constantinople.source
- 1579October 13 – Semiz Ahmed Pasha is appointed as the new Ottoman Grand Vizier by Sultan Murad III.source
- 1579November 13 – During the Second Desmond Rebellion, rebel troops in Ireland, led by Gerald FitzGerald, 14th Earl of Desmond, carry out the Sack of Youghal and massacre the English Army garrison, then pillage and burn the homes of local residents.source
- 1579November 21 – Iancu Sasul becomes the new Prince of Moldavia as Peter the Lame steps down for the second time. Peter will replace Sasul on October 17, 1582.source
- 1580February 16 – The massacre of 20 artists at the Mardi Gras festivities, at the annual Carnaval de Romans during the festival, takes place in France at Romans-sur-Isère.source
- 1580March 3 – George de Lalaing, Count of Rennenberg defects from the Union of Utrecht and the Dutch Republic, and turns over the province of Groningen to King Philip II of Spain.source
- 1580April 9 – English Fury at Mechelen: English and Scottish mercenaries, assisting the Dutch Republic, storm the Spanish Netherlands city of Mechelen (in modern-day Belgium), killing 60 civilians and plundering the town's houses and churches.source
- 1580June 9 – Rebels of the Dutch Union of Utrecht, aided by French soldiers, make a surprise attack on the Spanish Netherlands city of Diest in the Duchy of Brabant, and overwhelm the strategic location, now in Belgium, in one day.source
- 1580August 25 – Battle of Alcântara: Spanish armies, led by Fernando Álvarez de Toledo, defending the claim of King Philip II of Spain to the Portuguese throne, defeat the armies of Portuguese claimant António, Prior of Crato.source
- 1580October 18 – The Siege of Steenwijk in the Dutch Republic is started by the Spanish Netherlands. The siege will last four months and the Spanish troops will capture Steenwijk on February 23.source
- 1580October 24 – The War of the Portuguese Succession comes to an end as Spanish forces crush the final Portuguese resistance in the last stronghold in mainland Portugal, Porto. For the next 60 years, Portugal will be ruled by the Kings of Spain.source
- 1580November 10 – Second Desmond Rebellion: The Siege of Smerwick (now Ard na Caithne in County Kerry, Ireland) ends after three days when their commander surrenders to the English. Members of a group of at least 400 freelance soldiers, and perhaps as many as 700, for the Papal States are summarily executed on orders of the English Lord Deputy of Ireland, Baron Grey de Wilton.source
- 1581February 8 – (7th waxing of Tabaung 942 ME) Prince Shin Thissa, later to become King of Burma in 1599 as Nyaungyan Min, receives his first executive job when he is appointed to be Governor of Nyaungyan by his father, King Bayinnaung.source
- 1581February 23 – The Spanish Army is forced to abandon the siege of Steenwijk in the Netherlands after more than four months.source
- 1581May 26 – (10th waning of Nayon 943 ME) In Burma, Thiri Thudhamma Yaza of Martaban becomes the new Viceroy of Martaban (now Mottama in the Mon State of Myanmar) after the demise of Minye Nandameit.source
- 1581July 27 – Capture of Breda: After a surprise attack the day before, Spanish troops under the command of Claude de Berlaymont, Lord of Haultepenne, take the walled city Breda in the Netherlands. Once inside the gates, the Spanish troops overcome the defenders and carry out the massacre of 584 citizens in the "Haultepenne Fury".source
- 1581August 28 – The army of King Stephen Báthory of Poland begins its siege of the Russian garrison of Pskov.source
- 1581September 6 – A mercenary army of Sweden, under Pontus De la Gardie, captures Narva from Russia.source
- 1581September 30 – In Japan, warlord Oda Nobunaga invades the Iga Province. With 42,000 troops under his command against 10,000 defenders led by Takino Jurobei, Nobunaga controls most of central Japan within eight days.source
- 1581October 8 – The Tenshō Iga War ends in Japan with the surrender of Kashiwara Castle to Oda Nobunaga.source
- 1581John Dee practices angel magic with Barnabas Saul, but with no success.source
- 1582January 15 – Russia cedes its conquered areas in Livonia (Northern Latvia and Southern Estonia), to the Polish–Lithuanian Commonwealth.source
- 1582April 3 – Battle of Temmokuzan: Unable to reverse the collapse of Takeda clan, Takeda Katsuyori and his household commit suicide.source
- 1582April 17 – Siege of Takamatsu: In Japan, Toyotomi Hideyoshi departs from the Himeji Castle in the modern-day Hyōgo Prefecture and begins his march westward with 20,000 soldiers to the Bitchū Province in the modern-day Okayama Prefecture. Along the way, he stops at the Kameyama Castle where he makes a rendezvous with the Ukita clan and 10,000 additional forces before proceeding toward the Takamatsu Castle.source
- 1582May 17 – The Siege of Takamatsu begins as Hideyoshi attacks the forces of Shimizu Muneharu, who has twice as many soldiers. Hideyoshi orders an engineering project to block the Ashimori River and divert its waters to flood Takamatsu Castle.source
- 1582June 8 – Siege of Takamatsu: Heavy rains and the dikes built by Hideyoshi's forces turn the area around Takamatsu Castle into a lake.source
- 1582June 21 – (2nd day of the sixth month, Tenshō 10) The Honnō-ji Incident occurs in Kyoto in Japan, as Japanese warlord Oda Nobunaga, on the verge of unifying Japan under his rule, is assassinated following a betrayal by a rebel subject, Akechi Mitsuhide.source
- 1582June 23 – Shimizu Muneharu surrenders Takamatsu Castle to Toyotomi Hideyoshi and, in return for the pledge that the castle's defenders will be spared, commits the ritual suicide of seppuku.source
- 1582July 2 – Battle of Yamazaki: Counterattacking forces led by Toyotomi Hideyoshi decisively defeat Akechi Mitsuhide's smaller army; Akechi is killed while retreating to his domain.source
- 1582July 26 – Battle of Ponta Delgada (War of the Portuguese Succession): Spanish admiral Santa Cruz decisively defeats a larger mercenary fleet from France, England, supporters of the Portuguese claimant António, Prior of Crato, and the Dutch Republic, under Filippo di Piero Strozzi (who is killed) off the Azores, the first engagement between large fleets of galleons, operating at any great distance from the mainland.source
- 1582October 26 (Julian) (November 5 Gregorian) – General Yermak Timofeyevich completes the Russian conquest of Siberia in the Battle of Chuvash Cape as Kuchum Khan abandons Qashliq, the capital of the Khanate of Sibir. The Qashliq fortress will be torn down and a new town, Tobolsk will be built 11 mi further up the Irtysh river.source
- 1582The Cagayan battles in the Philippines, the only recorded clashes between Spanish regular soldiers and samurai warriors.source
- 1583January 18 – Francis, Duke of Anjou, attacks Antwerp.source
- 1583February 7 – In the Netherlands, the Siege of Eindhoven by the Spanish Army begins. The walled city will fall in April.source
- 1583April 23 – After a siege of 75 days, Dutch Republic commander Hendrik van Bonnivet surrenders Eindhoven to the Spanish Netherlands.source
- 1583April 25 – In a clash between a 50,000-man Persian Empire force and the Ottoman Empire for control of the Caucasus region in modern-day Russia, the Ottomans are routed.source
- 1583May 11 – In modern-day Russia, on the Caspian Sea, the three-day "Battle of Torches" ends as Ottoman Empire troops defeat forces of the Persian Empire.source
- 1583May 21 – Battle of Shizugatake in Japan: Shibata Katsuie is defeated by Toyotomi Hideyoshi, who goes on to commence construction of Osaka Castle.source
- 1583June 17 – Spanish troops under the command of Alexander Farnese, Duke of Parma overwhelm a combined army of Dutch, French and English soldiers at the Battle of Steenbergen in the modern-day Netherlands. The multinational force sustains 3,200 people killed or wounded.source
- 1583June 27 – Ten months after being taken hostage on August 23, 1582 in the Raid of Ruthven, the 17-year-old King James VI of Scotland is able to escape Falkland Prison and flees to safety in St. Andrews.source
- 1583July 25 – Cuncolim Revolt: The first documented battle of India's independence against a European colonial ruler is fought by the Desais of Cuncolim in Goa, against the Portuguese.source
- 1583October 24 – Jan van Hembyze becomes the last leader of the Calvinist Republic of Ghent after a coup d'etat against the ruling Count of Flanders. Hembyze's action leads days later to the siege of Ghent by Spanish General Alexander Farnese.source
- 1583December 17 – Cologne War: The Siege of Godesberg (begun on November 18) concludes when Catholic forces under Prince-elector-archbishop Ernest of Bavaria capture the strategic position, from defenders of the Calvinist convert Gebhard Truchsess von Waldburg.source
- 1584February 2 – (6th waning moon of the Magha, BE 2126) In what is now Thailand, Prince Naresuan, the Uparaja of the Ayutthaya Kingdom and the son of King Mahathammarachathirat carries out the orders of Burma's King Nanda Bayin, and leads an army to suppress a rebellion by the Viceroy of the Ava Kingdom, Thado Minsaw. Arriving in April, Naresuan learns that King Nanda has ordered Naresuan to be assassinated, and begins his own rebellion against Burma, the Burmese–Siamese War.source
- 1584April 24 – (1st waning of Kason 946 ME) In what is now Myanmar, Prince Naresuan of the Ayutthaya Kingdom (now Thailand) suppresses the rebellion of Thado Minsaw of the Ava Kingdom.source
- 1584April 28 – (Tenshō 12, 18th day of the 3rd month) In Japan, the Battle of Komaki begins as fight between Toyotomi Hideyoshi and Tokugawa Ieyasu when Ieyasu, commander of 100,000 men, begins the occupation of the Komakiyama Castle, prompting Hideyoshi to advance from Osaka with 30,000 troops.source
- 1584May 17 – (Tenshō 12, 8th day of the 4th month) The conflict between Toyotomi Hideyoshi and Tokugawa Ieyasu culminates in the Battle of Nagakute.source
- 1584July 3 – The Siege of Antwerp by the Spanish Army begins and lasts for 13 months until Antwerp's surrender on August 17, 1585.source
- 1584July 10 – Willem van Oranje, the leader of the Dutch Republic as Stadtholder of Holland, is assassinated in Delft. Balthasar Gérard, who bought two wheel-lock pistols and then made an appointment with at the Prinsenhof, shoots William in the chest at close range and fatally wounds him, making William the first head of state to be assassinated with a handgun.source
- 1584August 6 – Russian conquest of Siberia: Russian General Yermak Timofeyevich, who had been dispatched by Ivan the Terrible in 1582 to conquer the Khanate of Sibir, is killed along with all but one member of his invading force in an ambush commanded by Kuchum Khan, the ruler of Siberia.source
- 1584September 17 – In what is now Belgium, the Calvinist Republic of Ghent comes to an end after seven years when its capital, Ghent, falls following a siege of 13 months. Jan van Hembyze, leader of the republic since October 1583, surrenders the city to Alexander Farnese, Governor of the Spanish Netherlands.source
- 1584October 26 – At the Battle of Slunj in the Kingdom of Croatia, an Ottoman invasion led by Ferhad Pasha Sokolović is turned back by Croatian forces, aided by troops of the Habsburg monarchy.source
- 1584November 24 – Albert Fontenay sends an enciphered letter to Mary, Queen of Scots that will become the chief evidence against her in her trial for treason during the Babington Plot. After becoming a witness for the English government in return for immunity from prosecution, Jérôme Pasquier will decipher the letter in 1586, leading to Mary's conviction for an attempt to assassinate Queen Elizabeth and to overthrow the English government.source
- 1585March 10 – The Spanish Army, commanded by Alexander Farnese, Duke of Parma, obtains the surrender of Brussels after a siege that began the year before.source
- 1585May 19 – Spain seizes English ships in Spanish ports, precipitating the Anglo-Spanish War (1585–1604).source
- 1585June – Toyotomi Hideyoshi begins the invasion of the Japanese island of Shikoku with an army of 113,000 men on 703 ships. The troops are divided into three groups, with 60,000 commanded by Hashiba Hidenaga and Hashiba Hidetsugu toward the provinces of Awa and Tosa; 23,000 under Ukita Hideie at the province of Sanuki; and 30,000 under Kobayakawa Takakage and Kikkawa Motoharu for the province of Iyo.source
- 1585July 12 – Invasion of Shikoku: The final battle of the invasion, the siege of Ichinomiya Castle, begins.source
- 1585August 6 – (11th day of the 7th month of Tenshō 13) Invasion of Shikoku: In Japan, Chōsokabe Motochika surrenders the island of Shikoku to Toyotomi Hideyoshi, after a 26 day siege of the Ichinomiya Castle by 40,000 men.source
- 1585September 11 – In the Ottoman Empire, the rebellion of An-Nasir al-Hasan bin Ali in Yemen is ended when An-Nasir is betrayed and turned over to the Turkish Ottoman governor. An-Nasir spends one year in prison in Sanaa and then brought to Turkey.source
- 1585October 15 – In Arnhem in the Netherlands, the siege of IJsseloord is completed after nine days as English and Dutch forces recapture the city from Spanish occupiers.source
- 1585November 18 – In Mexico City, Álvaro Manrique de Zúñiga becomes Viceroy of New Spain after being appointed by King Philip II of Spain.source
- 1585November 28 – Anglo-Spanish War: The island of Santiago in Cape Verde is captured by Francis Drake.source
- 1585December 20 – Enraged by the disrespect shown to him by Yousuf Shah Chak, the Mughal Emperor, Akbar, orders the invasion of Kashmir with 5,000 men.source
- 1587February 8 – Mary, Queen of Scots, the monarch of Scotland from 1542 to 1567, is beheaded in front of 300 witnesses at Fotheringhay Castle, seven days after the signing of a death warrant by her cousin, Queen Elizabeth of England. Mary has been convicted of treason for her role in the Babington Plot, a conspiracy to overthrow the English government and to assassinate Elizabeth.source
- 1587April 20 (14th waxing of Kason 949 ME) – Burmese–Siamese War (1584–1593): Burma's siege of Ayutthaya (now in Thailand), capital of the Ayutthaya Kingdom, fails after six months as the troops of Burma's King Nanda Bayin begin their withdrawal.source
- 1587June 11 (Tensho 15, 6th day of 5th month) – Most of Kyushu is surrendered to Toyotomi Hideyoshi by Yoshihisa Shimazu, 32 days after Hideyoshi's siege of Kagoshima began (on the 3rd day of the 4th month). Hideyoshi follows on July 24 (19th day of the 6th month of Tensho 15) with an order banishing all European Christian missionaries from the province.source
- 1587October 7 – Sigismund Vasa and a fleet of Swedish ships land in Poland to confront an invasion by Maximilian III and an Austrian Army.source
- 1587October 14 – War of the Polish Succession (1587–1588): Archduke Maximilian of Austria begins the siege of Kraków, while Jan Zamoyski, hetman of the Polish Army, begins the defense of the city.source
- 1587October 20 – Battle of Coutras: Huguenot forces under Henry of Navarre defeat Royalist forces under Anne de Joyeuse, favorite of King Henry III of France; Joyeuse is killed.source
- 1587November 22 – A final Austrian attack on Kraków by Archduke Maximilian III is repelled by the Polish defenders.source
- 1587November 29 – Maximilian III withdraws his forces and the siege of Kraków ends.source
- 1588January 24 – War of the Polish Succession: The Battle of Pitschen takes place at Pitschen (modern Byczyna in Poland) with Polish and Lithuanian troops commanded by the Polish hetman Jan Zamoyski defending against an invading Austrian force commanded by Maximilian III, Archduke of Austria. After his army is routed, Archduke Maximilian surrenders and is taken as a prisoner of war, and will be held for more than a year until his release is compelled by the intervention of Pope Sixtus V.source
- 1588February 18 – In modern-day Sri Lanka, the siege of Colombo by King Rajasinha I of Sitawaka ends when Portuguese Admiral Pedro Teixeira arrives with a fleet of 80 ships and frees the capital of Portuguese Ceylon. King Rajasinha and his troops flee back to his capital at Seethawakapura.source
- 1588May 12 – Day of the Barricades in Paris: Henry I, Duke of Guise seizes the city, forcing King Henry III to flee.source
- 1588August 8 (July 29 Old Style) – Battle of Gravelines: The Spanish Armada is defeated by the English naval force off the coast of Gravelines, in the Spanish Netherlands (modern France).source
- 1588August 19 (August 9 Old Style) – Speech to the Troops at Tilbury by Queen Elizabeth I.source
- 1588September 1 – The Ganja Fortress in modern-day Azerbaijan is captured by Ottoman general Serdar Ferhad Pasha.source
- 1588September 13 – Dutch General Charles III de Croÿ captures the German city of Bonn in the Electorate of Cologne.source
- 1588November 13 – Dutch Republic and English forces capture Bergen op Zoom, a fortress in the Spanish Netherlands, after a siege of 41 days.source
- 1589March 6 – The Admiralty of the Noorderkwartier is set up as the third of the five admiralties in the Dutch Republic.source
- 1589May 11 – The Earl of Bothwell, accused of treason against the Crown of Scotland, surrenders along with the Earl of Huntly and is imprisoned at Holyrood Palace. Convicted on May 24, the conspirators are never sentenced and set free by King James VI.source
- 1589June 28 – On the island of Sumatra in what is now Indonesia, the Sultan of Aceh Darussalam, Ali Ri'ayat Syah II, is assassinated by a group of nobles dissatisfied with his rule. He becomes the fourth Sultan in a row to be murdered. Sayyid al-Mukammal is approved by the nobles as the new Sultan of Aceh.source
- 1589July 17 – (Tensho 17, 5th day of 6th month); The Battle of Suriagehara takes place in Japan between the Date and Katakura clans and the Ashina, Satake and Nikaido clans. Date Masamune leads the two clans to victory over Satake Yoshinobu.source
- 1589July 23 – Abbas the Great, who has recently become the Safavid Emperor of Persia, arranges the assassination of his benefactor, the Viceroy Murshid Qoli Khan at a banquet.source
- 1589September 21 – Battle of Arques: King Henry IV of France's forces defeat those of the Catholic League, under Charles of Lorraine, Duke of Mayenne (younger brother of Henry I, Duke of Guise).source
- 1589October 26 – Japanese warlord Date Masamune and his forces capture the Sukagawa Castle, defended by his aunt Onamihime Nikaido, after her assistant Hodohara Yukifuji betrays her.source
- 1589November 1 – Henry IV of France is repulsed in an attempt to capture Paris from the Catholic League.source
- 1590February 3 – Peter Ernst I von Mansfeld-Vorderort, the German-born commander of the Spanish Imperial Army captures the German fortress of Rheinberg after a four-year long siege during the Eighty Years' War.source
- 1590March 4 – Maurice of Nassau, Prince of Orange, takes Breda, by concealing 68 of his best men in a peat-boat, to get through the impregnable defenses.source
- 1590March 14 – Battle of Ivry: Henry IV of France again defeats the forces of the Catholic League, under Charles, Duke of Mayenne.source
- 1590April 24 – Ten armed English merchant vessels of the Levant Company are intercepted by 12 galleys of the Spanish Navy while attempting to pass through the Straits of Gibraltar after trading in the Mediterranean Sea. Levant Company's Benedict Barnham, on the flagship Salomon, leads the corporate fleet in a six-hour battle and heavily damages the Spanish ships, clearing the way for the company ships to return home.source
- 1590May 7 – King Henry of Navarre, claimant to the throne of France, begins an unsuccessful attempt to besiege Paris, at the time controlled by the Catholic League. By August 30, Henry is forced to raise the siege, when Alexander Farnese, Duke of Parma comes to its rescue with a Spanish army.source
- 1590June 23 – The Japanese samurai Toyotomi Hideyoshi sends an army of 15,000 men, led by generals Maeda Toshiie and Uesugi Kagekatsu, in an attack on the Hachiōji Castle in what is now Tokyo. The castle is lightly defended, by only 1,300 men, because the samurai Hōjō Ujiteru has most of his troops engaged in defending Hideyohsi's siege of Odawara. The castle is captured after one day, and later destroyed on orders of the shogun Tokugawa Ieyasu.source
- 1590August 4 – In Japan, the siege of Odawara, part of Toyotomi Hideyoshi's campaign to eliminate the clan of samurais led by Hōjō Ujinao, ends with the surrender of Odawara, part of Toyotomi's unification of the country.source
- 1590September 5 – Alexander Farnese's army forces Henry IV of France to lift the siege of Paris.source
- 1590October 13 – (5th waxing of Tazaungmon 952 ME) – In what is now Myanmar, King Nanda Bayin of Burma sends a 10,000-man army, led by the Viceroy Thado Dhamma Yaza III of Prome, and General Natshinnaung to suppress a rebellion in the Shan state of Mogaung.source
- 1590October 16 – Saadian invasion of the Songhai Empire: An army of 20,000 troops, led by Judar Pasha is dispatched from Marrakesh in the Saadi Sultanate (now Morocco), on orders of Sultan Ahmad al-Mansur. The Saadi Army's objective is to conquer the Songhai Empire, led by the Emperor Askia Ishaq II, in North Africa, corresponding to what is now the Republic of Mali.source
- 1590November 22 (12th waning of Tazaungmon 952 ME) – Burmese King Nanda Bayin sends a his son, the Crown Prince Mingyi Swa and 20,000 troops to what is now Thailand.source
- 1590The Spanish are pushed out of southern Gelderland by the Dutch forces.source
- 1591March 13 – Battle of Tondibi: In Mali, forces sent by the Saadi dynasty ruler of Morocco, Ahmad al-Mansur, and led by Judar Pasha, defeat the Songhai Empire, despite being outnumbered by at least five to one.source
- 1591April 21 – Japanese tea-master Sen no Rikyū commits seppuku, on the order of Toyotomi Hideyoshi.source
- 1591May 24 – Sir John Norreys, with an expeditionary force sent by Queen Elizabeth I of England, takes the town of Guingamp in Brittany after a brief siege, on behalf of Henry of Navarre.source
- 1591May 30 – Zutphen is captured by the Dutch and English, under Maurice of Nassau.source
- 1591June 10 – Deventer is captured by the Dutch, under Maurice of Nassau.source
- 1591June 26 – The siege of the Spanish Netherlands city of Delfzijl is started by Maurice, Prince of Orange, stadtholder of the Dutch Republic, who leads a Dutch and English Army against the Spanish defenders. Delfzijl falls after six days, and is surrendered on July 2.source
- 1591July 13 – A Crimean army, led by the Tatar Khan Ğazı II Giray, begins a siege of Moscow.source
- 1591July 15 – The Battle of the Berlengas takes place off of the coast of Portugal as the Earl of Cumberland's five English privateers are surprised by five Spanish galleys commanded by General Francisco Coloma, commander of the Armada de Guarda Costa. Cumberland's ship, the Golden Noble, is captured.source
- 1591July 18 (6 Shawal 999 AH) – In India, the four-day Battle of Bhuchar Mori ends in the Gujarat state, as General Mirza Aziz Koka leads the Mughal Empire gains a decisive victory over Nawanagar, led by the Sultan Muzaffar Shah III.source
- 1591July 25 – Siege of Knodsenburg: Dutch Republic stadtholder Maurice of Nassau and English General Francis Vere defeat the Duke of Parma outside Nijmegen after a four-day siege.source
- 1591August 1 – Serdar Ferhad Pasha is appointed the new Grand Vizier of the Ottoman Empire by Sultan Murad III, replacing Koca Sinan Pasha following a revolt of the Janissaries.source
- 1591August 9 – The Khan of the Crimean Tatara, Ğazı II Giray, is wounded by the defenders against his siege of Moscow. Gazi's brother, Fetih I Giray, continues the siege, which is finally settled with a peace agreement and payment of 10,000 rubles in 1594.source
- 1591August 30 – The Battle of Flores begins off Flores Island (Azores). By September 1, the Spanish fleet is victorious over the English and captures the English ship Revenge, fatally wounding Richard Grenville.source
- 1591September 4 – The Kunohe rebellion, which was started by Kunohe Masazane on March 13 on northern Honshu island in Japan's Mutsu Province (in the modern-day Iwate Prefecture), is suppressed by the samurai Toyotomi Hideyoshi, Chancellor of the Realm. The victory completes the unification of Japan.source
- 1591September 14 – Siege of Hulst: Hulst is captured by Maurice of Orange, the staatholder of the Dutch Republic.source
- 1591October 21 – The city of Nijmegen is captured from Spanish occupiers by Maurice of Orange, the staatholder of the Dutch Republic.source
- 1591October 26 – The Portuguese invasion of the Jaffna Kingdom begins on the north side of the island of Sri Lanka.source
- 1591November 6 – Hundred Years' Croatian–Ottoman War: The Ottoman Empire successfully captures the Croatian rebel fort of Ripač.source
- 1591November 11 – King Henry IV of France begins the siege of Rouen, the Spanish-held capital of Normandy. The Spanish Navy arrives after five months and King Henry abandons the siege on April 20.source
- 1591December 27 – Francis Stewart, Earl of Bothwell leads the attack on the Holyrood Palace in Edinburgh. Having been alerted by a premature attack on the palace's prison, King James VI of Scotland and Queen Anne are able to take refuge within the castle, and the raid fails. Seven of Bothwell's men are subsequently captured and hanged.source
- 1591The Siamese-Cambodian War begins.source
- 1591The defeated Askia dynasty move to the Dendi province in modern-day Niger.source
- 1592April 13 – The Japanese invasions of Korea (1592–98) begin with the Siege of Busanjin.source
- 1592April 20 – King Henry IV of France ends the siege of Rouen, the Spanish-held capital of Normandy, five months after its November 11 commencement, as the Spanish Navy arrives to relieve the city.source
- 1592April 24 – Battle of Sangju: The Japanese are victorious over the Koreans fighting for the Kingdom of Joseon.source
- 1592April 28 – Battle of Ch'ungju: Japan inflicts a decisive defeat on Korea.source
- 1592May 7 – Battle of Okpo: The Korean navy is victorious over Japan.source
- 1592May 20 –August 19 – Battle of Flores (Anglo-Spanish War (1585–1604)), a series of naval engagements in the Azores in which the English are victorious, taking the great Portuguese carrack Madre de Deus on or about August 3.source
- 1592May 29 – Battle of Sacheon: Korean admiral Yi Sun-sin destroys all 13 Japanese ships taking part, using his improved turtle ship for the first time in battle.source
- 1592June 2 – Battle of Dangpo:The Korean navy is again victorious over Japan.source
- 1592June 10 – The Siege of Bihać begins in the Kingdom of Croatia, by Telli Hasan Pasha (Hasan Predojević) of the Ottoman Empire. Bihać is captured on June 19 and is lost for Croatia forever.source
- 1592July 20 – The Japanese capture the Korean capital Hanyang, causing Seonjo to request the assistance of Ming dynasty Chinese forces, who recapture the city a year later.source
- 1592July 30 – Alonso de Sotomayor petitions the viceroy of Peru for more troops to help resist attacks by Indians and English pirates.source
- 1592August 14 – Battle of Hansan Island: The Korean navy defeats the Japanese.source
- 1592September 1 – Battle of Busan: The Korean fleet makes a surprise attack on the Japanese but fails to break their supply lines to Busan.source
- 1592October 5 – Siege of Jinju: The Korean navy is victorious over the Japanese.source
- 1592November 4 (2nd waxing of Natdaw, 954 ME) – In a war between what are now the nations of Myanmar and Thailand, the Army of Burma, led by King Nanda Bayin Burma (Toungoo) begins its invasion of the Ayutthaya Kingdom (Siam), defended by King Naresuan.source
- 1593January 25 – Siamese King Naresuan, in combat on elephant back, kills Burmese Crown Prince Mingyi Swa on Monday, Moon 2 Waning day 2, Year of the Dragon, Chulasakarat 954, reckoned as corresponding to January 25, 1593, of the Gregorian calendar, and commemorated as Royal Thai Armed Forces Day.source
- 1593February 2 – Battle of Piątek: Polish forces led by Janusz Ostrogski are victorious.source
- 1593February 8 – Siege of Pyongyang (1593): A Japanese invasion is defeated in Pyongyang by a combined force of Korean and Ming troops.source
- 1593February 12 – Battle of Haengju: Korea defeats Japan.source
- 1593April 18 – Anglo-Spanish War: Naval Battle of Blaye in the Gironde estuary sees a Spanish victory over the blockading English fleet, allowing the Spanish to relieve the French Catholic garrison of Blaye.source
- 1593June 7 – Battle of Salbertrand in Piedmont: Victory of François de Bonne, Duke of Lesdiguières, over the Spanish of Rodrigue Alvarez of Toledo, allies of Charles Emmanuel I, Duke of Savoy.source
- 1593June 22 – Battle of Sisak in Croatia: The Habsburgs defeat the Ottoman Empire.source
- 1593July 29 – The Long Turkish War breaks out in Hungary between the Habsburgs and the Ottomans.source
- 1593August 24 – After losing the Battle of Sisak two months earlier, the Ottoman Empire attacks the Austrian fortress guarding the city and breaks through its walls with cannon fire, forcing its surrender on August 30.source
- 1593September 10 – With no fortress or troops to defend Croatia, Ottoman General Mehmed Pasha captures the city of Sisak. Selânikî Mustafa Efendi, Tarih-i Selânikî (Türk Tarih Kurumu, 1999)source
- 1593October 11 – The Battle of Belleek takes place at County Fermanagh in Ireland as an English expeditionary force led by Henry Bagenal defeats Irish troops commanded by the Lord of Fermanagh.source
- 1593October 24 – Supposed date of the event described in the 1593 transported soldier legend.source
- 1593October 28 – The Siege of Coevorden begins as the Spanish Army attempts to retake a fortress captured a year earlier by the Dutch Republic and the Kingdom of England.source
- 1593December 6 – The Battle of Dryfe Sands takes place in Scotland at Annandale, between rival clans as John Maxwell leads Clan Maxwell, aided by Clan Grierson and Clan Pollock, in an invasion of the lands of Clan Johnstone, led by Sir James Johnstone. With their defense aided by Clan Scott and Clan Graham, the Johnstone clan wins the battle, but only 160 of the 600 defenders survive the fight.source
- 1593December 27 – Spanish Jesuit priest Gregorio Céspedes becomes the first Christian missionary to Korea, arriving at Busan to begin his ministry in the Buddhist kingdom of Joseon. Céspedes is able to enter Korea by coming with the Japanese invasion force of General Toyotomi Hideyoshi.source
- 1593Khwaja Usman takes shelter in Goyghor Mosque after the Afghan rebellion against the Subahdar of Mughal Bengal, Man Singh I.source
- 1594January 3 – Longvek, the capital of the Kingdom of Cambodia, is conquered by the army of the Ayutthaya Kingdom (now Thailand), commanded by King Naresuan, after more than two years of war. King Chey Chettha I of Cambodia is able to flee to Laos, along with the former King Satha I, but the rest of the royal family is taken hostage, along with Prince Srei Soriyopear. "King Tilokarat (1441–1485)", in Popular History of Thailand, by Manich Jumsai (Claremint, 1976) pp. 227–231source
- 1594January 25 – The siege of Enniskillen Castle in Ireland (at County Fermanagh) is started by English commander John Dowdall, but is abandoned after one month.source
- 1594March 18 – Two warships of the English Navy, commanded by Captain James Langton, complete a three-day raid on the Spanish city of Puerto de Caballos (now Puerto Cortés in Guatemala) and pillage the city.source
- 1594April 27 – After suppressing the Serbian uprising in Banat, the Ottoman Empire rulers carry out the public burning of the bones of Saint Sava in Belgrade.source
- 1594May 6 – The siege of the Spanish-held city of Coevorden ends after six months as the city surrenders to the Dutch Republic.source
- 1594May 19 – The Siege of Groningen by the Dutch Republic begins with an attack of 10,000 soldiers against the Spanish-held city. The Spanish commander surrenders after two months on July 22.source
- 1594July 1 – Anglo-Spanish War: Action of Atacames Bay – English privateer Richard Hawkins in the Dainty is attacked and captured by a Spanish squadron off Esmeraldas (now in Ecuador).source
- 1594July 3 – The Ayutthayan–Cambodian War (1591–1594) concludes when Naresuan, ruler of the Ayutthaya Kingdom, sacks Longvek, capital of Cambodia.source
- 1594July 22 – After a two-month siege, the city of Groningen submits to Dutch troops, bringing the whole northern Netherlands under the Dutch Republic.source
- 1594September 6 – In France, Morlaix, a walled city in Brittany controlled by the Spanish Army and the Ligue catholique, is besieged by the French Royal Army led by Marshal Jean VI d'Aumont. The French Army is supplemented by 2,000 troops commanded by John Norreys.source
- 1594September 17 – A fleet of six ships, commanded by the privateer Martin Frobisher, arrives at Morlaix and prepares to bombard the city, under siege by the French Army. The Spanish Army commander of the Morlaix garrison surrenders, rather than facing the city's destruction.source
- 1594October 1 – The siege of Fort Crozon begins as an English and French army attacks the Spanish held fortress at the Pointe des Espagnols in France.source
- 1594October 3 – The Battle of Glenlivet in Scotland: The Protestant forces loyal to King James VI, assisted by the armies of 8 clans and led by the Earl of Argyll, oppose Roman Catholic rebels supported by Clan Gordon (led by the Earl of Huntley), Clan Hay (led by the Earl of Errol), Clan Comyn and Clan Cameron. Despite being outnumbered 5 to 1, the Catholic clans win the battle, killing 500 of the Protestant forces.source
- 1594October 9 – Sinhalese–Portuguese War – Campaign of Danture: Forces of the Kingdom of Kandy gain a decisive victory over the Portuguese Empire, reversing near-total control of Sri Lanka by Portugal. Pedro Lopes de Sousa, the Governor of Portuguese Ceylon, is killed in the battle, and replaced on December 24 by Jerónimo de Azevedo.source
- 1594November 13 – After the Principality of Wallachia (now in Romania) joins other Eastern European nations in a Holy League, a rebellion breaks out in Bucharest as Christian residents massacre the soldiers of the Ottoman Muslim garrison, entering Wallachia into the ongoing Thirteen Years' War.source
- 1594November 18 – The Spanish fortress at Château de Brest in France falls after a siege of five months.source
- 1594November 19 – The siege of Fort Crozon by English and French soldiers ends with a massacre of all but 13 of the nearly 400 Spaniards living there, including women and children.source
- 1594December 15 – King Udai Singh of Marwar (now the Rajasthan and Punjab states of India and the Punjab province of Pakistan) returns to Lahore after having captured the Siwana fort.source
- 1594December 27 – French university student Jean Châtel attempts to assassinate King Henry IV of France, after gaining entrance into the King's office. Châtel attacks the monarch with a knife and causes a minor injury. After court jester Mathurine de Vallois intervenes, she detains Châtel until the King's bodyguard can carry out the arrest. Two days later, Chatel is executed by dismemberment. The Collège de Clermont, the Jesuit institution, where Châtel was a student, is closed, and the order of the Jesuits is temporarily banned.source
- 1595January 17 – During the French Wars of Religion, King Henry IV of France declares war on Spain, ordering Henry, Duke of Bouillon to lead armies through Luxembourg for an attack on the Spanish Netherlands (now Belgium).source
- 1595February 6 – Despite a string of military victories over the Serbian rebels, Koca Sinan Pasha is dismissed as Grand Vizier of the Ottoman Empire by Sultan Mehmed III, and banished to Malkara. He is replaced by Serdar Ferhad Pasha, whom he replaces on July 7.source
- 1595February 16 – In northern Ireland, Art MacBaron O'Neill successfully conducts the assault on the Blackwater Fort, an English military outpost located in County Armagh and captures it.source
- 1595March 20 – After a siege of 13 days, the French town of Huy (now in Belgium) is captured by the army of the Spanish Netherlands, as the General Charles de Héraugière surrenders to the Baron de la Motte.source
- 1595March 26 – Thado Dhamma Yaza III, who has served since 1589 for the Kingdom of Pegu as the Burmese Viceroy of Prome (now in the Bago Region of Myanmar), declares himself to be the King of Prome during the invasion by the Kingdom of Siam and breaks relations with his father King Nanda Bayin of Pegu.source
- 1595April 8 (March 29 O.S.) – Combined Taungoo–Lan Na armies break the rebel Thado Dhamma Yaza's siege of Taungoo, in modern-day Myanmar.source
- 1595June 9 – Battle of Fontaine-Française: Henry IV of France defeats the Spanish, but is nearly killed due to his rashness.source
- 1595July 23 – The Spanish raid Cornwall, England.source
- 1595August 23 – Battle of Calugareni: The Wallachians, led by Michael the Brave, accomplish a great tactical victory against a vast army of Turks, led by Sinan Pasha.source
- 1595October 26 – Battle of Giurgiu: Michael the Brave, led by Transylvanian Prince Sigismund Báthory, again defeats the Turkish army led by Sinan Pasha, pushing them on the east side of the Danube.source
- 1595November 8 – The Battle of Guadalupe Island is fought between nine English Navy warships (led by Sir Francis Drake) and eight Spanish frigates off in the North Atlantic Ocean. The Spanish force wins the battle, capturing one ship and killing 45 English sailors. Both sets of ships proceed toward Puerto Rico.source
- 1595November 22 – The Battle of San Juan is fought off of the island of Puerto Rico as an English fleet of 27 ships and 2,500 men, led by Francis Drake, attempts to invade the Spanish colony. In a three-day battle, the English lose at least eight ships and 400 men, including Admiral John Hawkins. Drake's fleet withdraws and attempts to conquer Panama.source
- 1595December 14 – Sultan Murad, 4th son of Emperor Akbar of the Mughal Empire invades Ahmednagar Sultanate which is defended by Chand Bibi.source
- 1595Many sugar plantations in São Tomé are destroyed by a large slave uprisingsource
- 1595The Austrians incite a rebellion against the Ottomans in Bulgaria.source
- 1596January 6 – Drake's Assault on Panama: Sir Francis Drake, General Thomas Baskerville and an English force of 15 ships land at the Atlantic Ocean port of Nombre de Dios in an attempt to capture the Isthmus of Panama.source
- 1596March 11 – The Battle of Pinos is fought between the English Navy (with 14 warships) and the Spanish Navy (with 13 galleons) off of the coast Cuba's Isla de Pinos, with 325 English Navy men killed or captured, while Spain drives Baskerville's ships to retreat and sustains 80 dead or wounded.source
- 1596March 15 – During Spain's Brittany Campaign during the Anglo-Spanish War, a Spanish ship carrying 25 soldiers invades England after arriving at Cawsand Bay in Cornwall. After starting a fire, the Spanish retreat.source
- 1596April 9 – Siege of Calais: Spanish troops capture Calais.source
- 1596August 18 – The siege of the Dutch city of Hulst is completed after a month as Spanish forces under the command of Albert, son of the late Holy Roman Emperor Maxmimilan II, force the surrender of the city.source
- 1596October 26 – Battle of Keresztes: The Ottoman Empire Turks defeat a combined Habsburg–Transylvanian army, after two days of fighting: .source
- 1596November 25 – The Cudgel War begins in Finland (at the time part of Sweden), when poor peasants rise up against the troops, nobles and cavalry who have taxed them.source
- 1596The Serb Uprising of 1596–97 begins.source
- 1597January 24 – Battle of Turnhout: Maurice of Nassau defeats a Spanish force under Jean de Rie of Varas, in the Netherlands.source
- 1597February 24 – The last battle of the Cudgel War is fought on the Santavuori Hill in Ilmajoki, Ostrobothnia.source
- 1597March 11 – Amiens is taken by Spanish forces.source
- 1597April 10 – The Serb uprising of 1596–97 ends in defeat for the rebels, at the field of Gacko (Gatačko Polje).source
- 1597April 19 – Prince Nyaungyan Min ignores the orders of King Nanda Bayin of Burma and seizes control of the Kingdom of Ava (now in Upper Myanmar)source
- 1597May 13 – King Henry IV of France and England's General Thomas Baskerville begin the siege of the city of Amiens in France, which had been captured on March 11 by the Spanish Army. The city is recaptured by September 25.source
- 1597August 13 – The Siege of Namwon begins in Korea.source
- 1597August 19 – Rheinberg capitulates to forces led by Maurice of Naussau.source
- 1597August 28 – Imjin War: Battle of Chilcheollyang – The Japanese fleet defeats the Koreans, in their only naval victory of the war.source
- 1597September 25 – Amiens is retaken from the Spanish by Anglo-French forces, led by Henry IV of France, after a four-month siege.source
- 1597October 18 – The 3rd Spanish Armada, a fleet of 140 ships, departs from the port of La Coruña with 12,634 soldiers and sailors and a plan to invade the British Isles with a landing at Falmouth in Cornwall.source
- 1597October 21 – The Spanish Armada reaches the English Channel without opposition. An English ship sees the invading force's approach, but is intercepted and sunk, with the survivors being taken prisoner. The Armada encounters a storm the next day.source
- 1597October 25 – Following the loss of an artillery ship and the galleon San Bartolome, Spanish Admiral Diego Brochero orders the remaining ships in the attacking Armada to disperse until the weather improves.source
- 1597October 26 – Battle of Myeongnyang: The Koreans, commanded by Yi Sunsin, are victorious over a Japanese invasion fleet.source
- 1597November 10 – In the last major action during the war of the 3rd Spanish Armada, the galleon Bear of Amsterdam is captured as it approaches Falmouth, where an English squadron intercepts it and leads it into Dartmouth.source
- 1597November 12 – Lingen capitulates to forces led by Maurice of Nassau.source
- 1597November 21 – The remainder of the 3rd Spanish Armada is assembled at La Coruña. Only 108 of the original fleet of 140 ships is left, and many of the vessels require food and supplies. King Philip elects not to attempt another invasion of the British Isles.source
- 1597Abbas I ends the Uzbek raids on his lands.source
- 1598January 29 – In what is now South Korea, a force of 50,000 troops of the Korean kingdom of Joseon and Chinese Ming dynasty troops begins the siege of Ulsan, a Japanese-controlled castle located in the southwest port of Ulsan on the Sea of Japan.source
- 1598March 19 – Count Adolf von Schwarzenberg of Austria captures the Turkish fortress at Győr, four years after Turkish forces had taken it over.source
- 1598March 20 – The Duchy of Brittany in France is conquered by King Henry IV, who forces the surrender of Philippe Louis de Lorraine-Mercœur, Duke of Brittany. Merceur is then exiled to Hungary.source
- 1598June 15 – England invades the Caribbean island of Puerto Rico with a force of 20 ships and 1,700 men led by the Earl of Cumberland.source
- 1598July 23 – Sigismund III Vasa, King of Poland and Grand Duke of Lithuania, departs from Danzig (now Gdańsk) with 80 transports, several warships and exiled members of the Swedish parliament to invade Sweden. The troops land at Kalmar on July 31, and secure its surrender.source
- 1598July – Philosopher Tommaso Campanella moves from Naples to Calabria, where he will be involved in a revolt against the rule of the Spanish viceroy the following year.source
- 1598August 14 – Battle of the Yellow Ford in Ireland: Hugh O'Neill, Earl of Tyrone, gains victory over an English expeditionary force under Henry Bagenal, in the Nine Years' War against English rule.source
- 1598September 10 – Prince Michael II of Wallachia begins the siege of Nicopolis (now Nikopol in Bulgaria).source
- 1598September 25 – Battle of Stångebro at Linköping in Sweden: The Catholic King Sigismund of Sweden and Poland is defeated in his attempt to resume control of Sweden by the Protestant forces of his uncle, Charles. Sigismund is deposed shortly thereafter.source
- 1598October 19 – The Siege of Suncheon, an attempt by Korean and Chinese troops to capture the Japanese-occupied Suncheon Castle. An attempt to lure Japanese General Konishi Yukinaga into an ambush fails when a Korean Army cannon is fired too early and gives away the Korean plan.source
- 1598November 2 – Admiral Yi Sunsin of the Korean Navy attempts to bombard the Suncheon Castle, two days after the joint Chinese and Korean land assault is driven back. Korea and China lose 39 ships when a large number of the fleet gets stuck in the shallow waters at low tide and the vessels are attacked by the Japanese. Yi Sunsin calls off the siege the next day.source
- 1598November 10 (11th waxing of Tazaungmon 960 ME) – In what is now the Rakhine State of Myanmar, King Min Razagyi of Arakan and the rebel leader Minye Thihathu begin their assault on Pegu, the remaining portion of the Toungoo Empire in southern Burma.source
- 1598December 16 (Keichō 3, 19th day of the 11th month, lunar calendar) – Battle of Noryang: An allied Korean and Chinese fleet under Korean Admiral Yi Sun-sin and Chinese Admiral Chen Lin defeats the Japanese navy, ending the Japanese invasions of Korea (1592–98).source
- 1598December 21 – Battle of Curalaba: The revolting Mapuche, led by cacique Pelantaro, inflict a major defeat on Spanish troops in southern Chile; all Spanish cities south of the Bío Bío River eventually fall victim to the Destruction of the Seven Cities by the Mapuches, and all conquest of Mapuche territories by Europeans practically ceases, until the later 19th century Occupation of Araucanía.source
- 1599January 22 – Acoma Massacre: Santa Fe de Nuevo Mexico viceroy Juan de Oñate leads 70 armed Spanish soldiers against the indigenous Keres people at Aak'u (the Acoma Pueblo), near what is now Albuquerque, New Mexico. In three days, 500 Acoma men and 300 women and children are killed by the Spanish.source
- 1599March 12 – Robert Devereux, 2nd Earl of Essex, is appointed Lord Lieutenant of Ireland, by Queen Elizabeth I of England.source
- 1599April 23 – The Earl of Essex arrives in Dublin at the head of 16,000 troops, the largest army ever seen in Ireland.source
- 1599May 15 – Anglo-Spanish War (1585–1604): The Siege of Zaltbommel, located in the Dutch Republic, is begun by Spanish general Francisco López de Mendoza.source
- 1599May 16 – The Kalmar Bloodbath takes place in Kalmar, Sweden.source
- 1599May 29 – Essex takes Cahir Castle, supposedly the strongest in Ireland, after a short siege.source
- 1599July 22 – The combined Dutch and English armies successfully defend Zaltbommel after a siege of two months.source
- 1599August 15 – First Battle of Curlew Pass: Irish forces defeat the English.source
- 1599September 28 – The Earl of Essex arrives back in England, disobeying the Queen's strict orders.source
- 1599October 18 – Battle of Sellenberk: Michael the Brave, Prince of Wallachia, defeats the army of Andrew Báthory near Șelimbăr, leading to the first recorded unification of the Romanians.source
- 1599November 10 – The Åbo Bloodbath takes place in Åbo (Turku), in modern-day Finland, which was part of Sweden at the time.source
- 1599December 19 – The forces of Minye Thihathu II of Toungoo and his ally Min Razagyi of the Kingdom of Mrauk U end the First Toungoo Empire by capturing Pegu (modern-day Bago, Myanmar).source